“These findings, for the first time, suggest that brain CB2 receptors modulate cocaine’s rewarding and locomotor-stimulating effects, likely by a DA-dependent mechanism.
Whatever the mechanisms, the present findings, for the first time, suggest that activation of brain CB2 receptors inhibits cocaine’s rewarding and psychomotor-stimulating effects, which is congruent with a rapidly expanding corpus of published reports implicating brain CB2 receptors in modulating a variety of CNS functions such as locomotion, pain, emesis, neurogenesis, and neuroprotection.
This finding not only challenges current views that CB2 receptors are absent from the CNS and that CB2 receptor ligands lack CNS effects, but also suggests that brain CB2 receptors may be a novel target for the pharmacotherapy of drug abuse and addiction.” http://europepmc.org/articles/pmc3164946