Effect of cannabinoid receptor activation on spreading depression.

“Cannabis has been used for centuries for both symptomatic and prophylactic treatment of different types of headaches including migraine…

Suppression of CSD (cortical spreading depression) by activation of CB1 receptors suggests the potential therapeutic effects of cannabinoids in migraine with aura as well as other CSD-related disorders.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586901/

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