“Cannabinoids produce analgesia through a variety of mechanisms.
It has been proposed that one mechanism is by modulating the release of CGRP in the spinal cord pain pathways.
Previous studies have reported that cannabinoids, particularly CB2 receptor agonists, can modulate CGRP release in the isolated rat spinal cord.
These results question the role of spinal cord cannabinoid receptors in the regulation of CGRP signalling.”