Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice.

“Overexpression of CB2r reduced anxiety-like behaviours in… mice…

 Our findings revealed that increased expression of CB2r significantly reduced anxiogenic-related behaviours, modified the response to stress and impaired the action of anxiolytic drugs.”

http://www.ncbi.nlm.nih.gov/pubmed/20837564

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