Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors.

“The aim of this study was to explore the effects of CB(2) receptor agonist and antagonist in the regulation of anxiety-like behaviours…The opposing behavioural and molecular changes observed after chronic treatment… support the key role of CB(2) receptors in the regulation of anxiety. Indeed, the efficacy in reducing the anxiety of the spontaneously anxious strain of mice strengthens the potential of the CB(2) receptor as a new target in the treatment of anxiety-related disorders.”

http://www.ncbi.nlm.nih.gov/pubmed/21838753

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