Pharmacological inhibition of MAGL lipase attenuates experimental colon carcinogenesis.

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“Colorectal cancer (CRC) is a major health problem in Western countries. The endocannabinoid 2-arachidonoyl-glycerol (2-AG) exerts antiproliferative actions in a number of tumoral cell lines, including CRC cells.

Monoacylglycerol lipase (MAGL), a serine hydrolase that inactivates 2-AG, is highly expressed in aggressive human cancer cells.

Here, we investigated the role of MAGL in experimental colon carcinogenesis.

MAGL, possibly through modulation of angiogenesis, plays a pivotal role in experimental colon carcinogenesis.

Pharmacological inhibition of MAGL could represent an innovative therapeutic approach to reduce colorectal tumor progression.”

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