Signaling Mechanism of Cannabinoid Receptor-2 Activation-Induced β-Endorphin Release.

“Activation of cannabinoid receptor-2 (CB2) results in β-endorphin release from keratinocytes, which then acts on primary afferent neurons to inhibit nociception.

Our data also suggest that stimulation of MAPK contributes to the peripheral analgesic effect of CB2 receptor agonists.”

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