“CB₂ receptors up-regulate in reactive microglia in the spinal cord of TDP-43(A315T) transgenic mice, an experimental model of ALS.

To determine whether such up-regulation may be pharmacologically exploited, we investigated different treatments modulating the CB₂ receptor function.

CONCLUSIONS AND IMPLICATIONS:

Our study shows an important role for glial CB₂ receptors in limiting the progression of the pathological phenotype in TDP-43(A315T) transgenic mice. Such benefits derived apparently from the activation of CB₂ receptors concentrated in astrocytes and reactive microglia located in spinal dorsal and ventral horns.”

https://www.ncbi.nlm.nih.gov/pubmed/29574689

https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14216