The cannabinoid receptor CB₁ inverse agonist AM251 potentiates the anxiogenic activity of urocortin I in the basolateral amygdala.

The basolateral amygdala is reported to play an important role in the neural bases of emotional processing… Based on these findings, we propose that urocortin and endocannabinoid signaling are part of an integrated neural axis modulating anxiety states within the basolateral amygdala. This article is part of a Special Issue entitled ‘Anxiety and Depression’.”

http://www.ncbi.nlm.nih.gov/pubmed/21736884

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