“(E)-beta-caryophyllene (BCP) is an aromatic sesquiterpene that has used for many years as a food additive because of its peppery flavour. The researchers now say that it interacts selectively with one of two cannabinoid receptors, CB₂, blocking the chemical signals that lead to inflammation without triggering cannabis’s mood-altering effects.

 

Many cannabinoids bind to the CB₂ receptor, but few target it selectively. Most also interact with CB₁, which is responsible for cannabis’ psychoactive properties. CB₁ is found in brain tissue, whereas CB₂is found only in cells elsewhere in the body.”