“Cannabidiol (CBD), the main non-psychotomimetic component of marihuana…
…we have evaluated the effects of CBD following acute and chronic administration in the olfactory bulbectomy mouse model of depression…
In conclusion, our findings indicate that CBD could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate cortical signalling through a 5-HT1A receptor-dependent mechanism.”