Changes in the Brain Endocannabinoid System in Rat Models of Depression.

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“A growing body of evidence implicates the endocannabinoid (eCB) system in the pathophysiology of depression.

The aim of this study was to investigate the influence of changes in the eCB system, such as levels of neuromodulators, eCB synthesizing and degrading enzymes, and cannabinoid (CB) receptors, in different brain structures in animal models of depression using behavioral and biochemical analyses.

These findings suggest that dysregulation in the eCB system is implicated in the pathogenesis of depression, although neurochemical changes were linked to the particular brain structure and the factor inducing depression (surgical removal of the olfactory bulbs vs. genetic modulation).”

https://www.ncbi.nlm.nih.gov/pubmed/28247204

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