“Nighttime agitation occurs frequently in patients with dementia and represents the number one burden on caregivers today. Current treatment options are few and limited due to substantial side effects.
OBJECTIVES:
The aim of the study was to measure the effect of the cannabinoid dronabinol (THC) on nocturnal motor activity.
RESULTS:
Compared to baseline, dronabinol led to a reduction in nocturnal motor activity. These findings were corroborated by improvements in Neuropsychiatric Inventory total score as well as in subscores for agitation, aberrant motor, and nighttime behaviors . No side effects were observed.
CONCLUSIONS:
The study suggests that dronabinol (THC) was able to reduce nocturnal motor activity and agitation in severely demented patients. Thus, it appears that dronabinol (THC) may be a safe new treatment option for behavioral and circadian disturbances in dementia.”
http://www.ncbi.nlm.nih.gov/pubmed/16521031
https://link.springer.com/article/10.1007%2Fs00213-006-0343-1
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