“The endocannabinoid system is dysregulated in schizophrenia.
These results demonstrate for the first time in vivo interplay between Nrg1 and endocannabinoids in the brain.
Our results demonstrate that aberrant Nrg1 and endocannabinoid signalling may cooperate in the hippocampus to impair cognition in schizophrenia, and that Nrg1 deficiency alters endocannabinoid signalling in brain stress circuitry.”