Ligand activation of cannabinoid receptors attenuates hypertrophy of neonatal rat cardiomyocytes.

“Endocannabinoids are bioactive amides, esters, and ethers of long-chain polyunsaturated fatty acids.

Evidence suggests that activation of the endocannabinoid pathway offers cardioprotection against myocardial ischemia, arrhythmias, and endothelial dysfunction of coronary arteries.

In conclusion, CB-13 inhibits cardiomyocyte hypertrophy through AMPK-eNOS signaling and may represent a novel therapeutic approach to cardioprotection.”

http://www.ncbi.nlm.nih.gov/pubmed/24979612

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