Role of cannabinoid receptor 1 in human adipose tissue for lipolysis regulation and insulin resistance.

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“We recently showed that the peripheral cannabinoid receptor type 1 (CNR1) gene is upregulated by the synthetic glucocorticoid dexamethasone.

CNR1 is highly expressed in the central nervous system and has been a drug target for the treatment of obesity.

Here we explore the role of peripheral CNR1 in states of insulin resistance in human adipose tissue.

CNR1 is upregulated in states of type 2 diabetes and insulin resistance.

Furthermore, CNR1 is involved in glucocorticoid-regulated lipolysis.

Peripheral CNR1 could be an interesting drug target in type 2 diabetes and dyslipidemia.”

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