“Patients with ulcerative colitis (UC) using marijuana have been reported to experience symptomatic benefit.
Cannabidivarin (CBDV) is a safe non-psychoactive phytocannabinoid able to activate TRPA1, a member of TRP channels superfamily, which plays a pivotal role in intestinal inflammation.
Here, we have investigated the potential intestinal anti-inflammatory effect of CBDV in mice and in biopsies from pediatric patients with active UC.
Our preclinical study shows that CBDV exerts intestinal anti-inflammatory effects in mice via TRPA1, and in children with active UC.
Since CBDV has a favorable safety profile in humans, it may be considered for possible clinical trials in patients with UC.”