Antihyperalgesic effect of CB1 receptor activation involves the modulation of P2X3 receptor in the primary afferent neuron.

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“Cannabinoid system is a potential target for pain control.

Cannabinoid receptor 1 (CB1) activation play a role in the analgesic effect of cannabinoids once it is expressed in primary afferent neurons.

This study investigates whether the anti-hyperalgesic effect of CB1receptor activation involves P2×3 receptor in primary afferent neurons.

Our data suggest that the analgesic effect of CB1 receptor activation is mediated by a negative modulation of the P2×3 receptor in the primary afferent neurons.”

https://www.ncbi.nlm.nih.gov/pubmed/28131783

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