Restoration of osteogenic differentiation by overexpression of cannabinoid receptor 2 in bone marrow mesenchymal stem cells isolated from osteoporotic patients.

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“Cannabinoid receptor 2 (CNR2) has a critical role in osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). CNR2 expression was found to be downregulated in osteoporotic patients.

The present study aimed to investigate the functionality of CNR2 in restoring osteogenic differentiation and mineralization of BMSCs isolated from osteoporotic patients.

The results demonstrated that overexpression of CNR2 in osteoporotic BMSCs increased ALP activity, promoted expression of osteogenic genes and enhanced deposition of mineralized extracellular matrix. In addition, phosphorylation of p38 MAPK was found to be increased by overexpression of CNR2.

In conclusion, the present study indicated that restoration of CNR2 recovered the osteogenic differentiation of BMSCs isolated from osteoporotic patients. This finding may provide a novel strategy for a treatment approach for osteoporosis.”

https://www.ncbi.nlm.nih.gov/pubmed/29250156

https://www.spandidos-publications.com/10.3892/etm.2017.5369

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One thought on “Restoration of osteogenic differentiation by overexpression of cannabinoid receptor 2 in bone marrow mesenchymal stem cells isolated from osteoporotic patients.

  1. I am 54 years old and was diagnosed with OSTEOPOROSIS in 2015. The results of the scan indicated that I had the bones of a 75 year old. I was on Fosamax for years, before switching to Boniva since it could be taken once monthly. After a year of taking Boniva, my latest bone density test showed that both my hips had gotten worse. My primary care provider suggested i try a more natural approach and referred me to RICH HERBS FOUNDATION, i immediately started on their OSTEOPOROSIS HERBAL FORMULA. The treatment effectively reversed my condition. I did another bone density test and it came out perfect. Visit rich herbs foundation web page w w w. r i c h h e r b s f o u n d a t i o n. com. The severe knee pain and sharp pains through my back stopped.

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