“Activation of Kupffer cells plays a central role in the pathogenesis of alcoholic liver disease.
Because cannabinoid CB2 receptors (CB2) display potent anti-inflammatory properties, we investigated their role in the pathogenesis of alcoholic liver disease, focusing on the impact of CB2 on Kupffer cell polarization and the consequences on liver steatosis.
Altogether, these findings demonstrate that CB2 receptors display beneficial effects on alcohol-induced inflammation by regulating M1/M2 balance in Kupffer cells, thereby reducing hepatocyte steatosis via paracrine interactions between Kupffer cells and hepatocytes.
These data identify CB2 agonists as potential therapeutic agents for the management of alcoholic liver disease.”
Thanks, it helps!