Cannabinoid Receptor-2 Ameliorates Inflammation in Murine Model of Crohn’s Disease.

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“Cannabinoid receptor stimulation may have positive symptomatic effects on inflammatory bowel disease [IBD] patients through analgesic and anti-inflammatory effects.

The cannabinoid 2 receptor [CB2R] is expressed primarily on immune cells, including CD4+ T cells, and is induced by active inflammation in both humans and mice. We therefore investigated the effect of targeting CB2R in a preclinical IBD model.

 In summary, the endocannabinoid system is induced in murine ileitis but is downregulated in chronic murine and human intestinal inflammation, and CB2R activation attenuates murine ileitis, establishing an anti-inflammatory role of the endocannabinoid system.”

https://www.ncbi.nlm.nih.gov/pubmed/28981653

https://academic.oup.com/ecco-jcc/article-abstract/doi/10.1093/ecco-jcc/jjx096/3977952/Cannabinoid-Receptor-2-Ameliorates-Inflammation-in?redirectedFrom=fulltext

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