“Increasing evidence that low doses of cannabinoid agonists reduce anxiety-like behaviors in mice and rats is being reported, thus suggesting an anxiolytic role for the endogenous cannabinoid signaling. In line with this hypothesis, pharmacological agents that enhance the endogenous cannabinoid signaling exert anxiolytic-like actions…
These findings support an anxiolytic role for physiological increases in AEA in the PFC, whereas more marked increases or decreases of this endocannabinoid might lead to an anxiogenic response due to TRPV1 stimulation or the lack of CB1 activation, respectively.”