“Previous studies have shown that cannabinoidergic system is involved in anxiety.
The aim of this study is to evaluate the effect of pharmacological stimulation or blocking of CB1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (EPM) test in rat.
It is concluded that activation of cannabinoid receptor exert anxiolytic effect while blocking of cannabinoid receptor resulted in anxiety behavior. The locomotor activity was not significantly changed by cannabinoid system.
It is suggested that potentiation of cannabinoid system may be therapeutic strategy for the anxiety behavior.”