“Endocannabinoids (ECs) are important regulators of cell signaling.
Cannabinoid receptors are involved in keratinocyte proliferation/differentiation.
Elevation of the endogenous cannabinoid tone leads to strong anti-inflammatory effects.
Here, we explored the influence of endocannabinoid system (ECS) modulators on skin permeability barrier repair, epidermal proliferation, differentiation and inflammation in hairless mice.
We used WOBE440, a selective fatty acid amide hydrolase (FAAH) inhibitor, WOL067-531, an inhibitor of endocannabinoid reuptake with no relevant FAAH activity, which both signal via cannabinoid receptor-1and 2 (CB-1R and CB-2R) and compared them to WOBE15 which signals via CB-2R.
We found that barrier repair was significantly delayed by WOL067-531.
In summary, we showed that WOL067-531 exhibits a significant effect on skin barrier repair, epidermal proliferation/differentiation and inflammation.”