Modulators of the endocannabinoid system influence skin barrier repair, epidermal proliferation, differentiation and inflammation in a mouse model.

Experimental Dermatology banner“Endocannabinoids (ECs) are important regulators of cell signaling.

Cannabinoid receptors are involved in keratinocyte proliferation/differentiation.

Elevation of the endogenous cannabinoid tone leads to strong anti-inflammatory effects.

Here, we explored the influence of endocannabinoid system (ECS) modulators on skin permeability barrier repair, epidermal proliferation, differentiation and inflammation in hairless mice.

We used WOBE440, a selective fatty acid amide hydrolase (FAAH) inhibitor, WOL067-531, an inhibitor of endocannabinoid reuptake with no relevant FAAH activity, which both signal via cannabinoid receptor-1and 2 (CB-1R and CB-2R) and compared them to WOBE15 which signals via CB-2R.

We found that barrier repair was significantly delayed by WOL067-531.

In summary, we showed that WOL067-531 exhibits a significant effect on skin barrier repair, epidermal proliferation/differentiation and inflammation.”

https://www.ncbi.nlm.nih.gov/pubmed/31350927

https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.14012

Facebook Twitter Pinterest Stumbleupon Tumblr Posterous

Leave a Reply

Your email address will not be published. Required fields are marked *