Differential role of cannabinoids in the pathogenesis of skin cancer.

“Cannabinoids (CB) like ∆9-tetrahydrocannabinol (THC) can induce cancer cell apoptosis and inhibit angiogenesis.

Here we investigated the role of exogenous and endogenous cannabinoids in mouse skin cancer.

THC significantly inhibited tumor growth of transplanted HCmel12 melanomas in a CB receptor-dependent manner in vivo through antagonistic effects on its characteristic pro-inflammatory microenvironment.

Our results confirm the value of exogenous cannabinoids for the treatment of melanoma…”



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