“We observe significant improvement of symptoms of FM in patients using cannabis… knowledge of the endocannabinoid system and the role of the stress system in the pathopysiology of FM suggest a new approach to the suffering of these patients… results together with previous evidence seem to confirm the beneficial effects of cannabinoids on FM symptoms.”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080871/?tool=pubmed
“The hemp plant Cannabis sativa produces unique compounds known as cannabinoids, of which Δ9-tetrahydrocannabinol (THC) is the most important… The present study was undertaken to investigate the antitumoral action of cannabinoids in pancreatic cancer and the molecular mechanisms involved in that effect… Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes…These findings may contribute to set the basis for a new therapeutic approach for the treatment of pancreatic cancer.”
” Here, we show that Delta(9)-tetrahydrocannabinol (THC), through activation of CB(2) cannabinoid receptors, reduces human breast cancer cell proliferation by blocking the progression of the cell cycle and by inducing apoptosis… these data might set the bases for a cannabinoid therapy for the management of breast cancer.”
http://www.ncbi.nlm.nih.gov/pubmed/16818634
“We therefore investigated the role of the CB-Rs (CannaBinoid-Receptors) in mediating apoptosis in 3 leukemic cell lines… We have shown that THC is a potent inducer of apoptosis… THC-induced cell death…”
http://bloodjournal.hematologylibrary.org/content/105/3/1214.long
“The active ingredient in marijuana cuts tumor growth in common lung cancer in half and significantly reduces the ability of the cancer to spread, say researchers at Harvard University who tested the chemical in both lab and mouse studies.”
http://www.sciencedaily.com/releases/2007/04/070417193338.htm
“Cannabinoids exert antiproliferative properties in a variety of malignant tumors, including pancreatic ductal adenocarcinoma … Cannabinoids can induce apoptosis (programmed cell death) in cancer cells…Furthermore, they have been shown to decrease invasiveness of cancer cells.”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225529/?tool=pubmed
“Delta9-Tetrahydrocannabinol, the main active component of marijuana… Here, we show that intratumoral administration of Delta9-tetrahydrocannabinol…
”Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death…”
The study by Manuel Guzmán of Madrid Spain found that cannabinoids, the active components of marijuana, inhibit tumor growth in laboratory animals. They do so by modulating key cell-signalling pathways, thereby inducing direct growth arrest and death of tumor cells, as well as by inhibiting the growth of blood vessels that supply the tumor.
“Hepatocellular carcinoma (HCC) is the third cause of cancer-related death worldwide… few therapeutic options are available… we investigated the effects of cannabinoids–a novel family of potential anticancer agents–on the growth of HCC. We found that Δ(9)-tetrahydrocannabinol (Δ(9)-THC, the main active component of Cannabis sativa)… reduced the viability of the human HCC cell lines…cannabinoids were also able to inhibit tumor growth… Our findings may contribute to the design of new therapeutic strategies for the management of HCC.”
“… the EndoCannabinoid System has been implicated in a growing number of physiological functions of the nervous system and various peripheral organs, and its modulation turned out to hold tremendous therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders, neuropathic pain, multiple sclerosis, and spinal cord injury to cancer, glaucoma, osteoporosis, atherosclerosis, myocardial infarction, stroke, hypertension, and obesity/ metabolic syndrome to name just a few…”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791499/?tool=pubmed