Tag Archives: obesity

Cannabidiol promotes browning in 3T3-L1 adipocytes.

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“Recruitment of the brown-like phenotype in white adipocytes (browning) and activation of existing brown adipocytes are currently being investigated as a means to combat obesity.

The present study was designed to investigate the effects of cannabidiol (CBD), a major nonpsychotropic phytocannabinoid of Cannabis sativa, on induction of browning in 3T3-L1 adipocytes.

These data suggest possible roles for CBD in browning of white adipocytes, augmentation of lipolysis, thermogenesis, and reduction of lipogenesis.

In conclusion, the current data suggest that CBD plays dual modulatory roles in the form of inducing the brown-like phenotype as well as promoting lipid metabolism.

Thus, CBD may be explored as a potentially promising therapeutic agent for the prevention of obesity.”

http://www.ncbi.nlm.nih.gov/pubmed/27067870

http://www.thctotalhealthcare.com/category/obesity-2/

Link between obesity and cancer – Science

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“Link between obesity and cancer” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670342/

“Biological mechanisms linking obesity and cancer risk: new perspectives.” http://www.ncbi.nlm.nih.gov/pubmed/19824817

“Overweight/obesity and cancer genesis: more than a biological link.” http://www.ncbi.nlm.nih.gov/pubmed/18035514

“The Obesity-Cancer Link: Lessons Learned from a Fatless Mouse” http://cancerres.aacrjournals.org/content/67/6/2391.long

“Epidemiology and pathophysiology of obesity as cause of cancer.” http://www.ncbi.nlm.nih.gov/pubmed/17299670

“Obesity and cancer.” http://www.ncbi.nlm.nih.gov/pubmed/19924603

“Obesity and cancer: pathophysiological and biological mechanisms.” http://www.ncbi.nlm.nih.gov/pubmed/18465361

“Obesity and cancer risk: evidence, mechanisms, and recommendations” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476838/

 “The growing challenge of obesity and cancer: an inflammatory issue.” http://www.ncbi.nlm.nih.gov/pubmed/21793838

“Growth Signals, Inflammation, and Vascular Perturbations, Mechanistic Links Between Obesity, Metabolic Syndrome, and Cancer” http://atvb.ahajournals.org/content/32/8/1766.long

  “Obesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issue” http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2012.06737.x/full

 “Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.” http://www.ncbi.nlm.nih.gov/pubmed/23803760

“Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms” http://www.nature.com/nrc/journal/v4/n8/full/nrc1408.html

“Overweight and obesity: a review of their relationship to metabolic syndrome, cardiovascular disease, and cancer in South America.” http://www.ncbi.nlm.nih.gov/pubmed/23452284

“Cytokines, obesity, and cancer: new insights on mechanisms linking obesity to cancer risk and progression.” http://www.ncbi.nlm.nih.gov/pubmed/23121183

“Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555202/

“Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23622129

“Obesity, energy balance, and cancer: new opportunities for prevention.” http://www.ncbi.nlm.nih.gov/pubmed/23034147

 “Obesity and colorectal cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23481261

“Obesity and Risk of Colorectal Cancer: A Meta-analysis of 31 Studies with 70,000 Events” http://cebp.aacrjournals.org/content/16/12/2533.long

 “Obesity and Risk of Colorectal Cancer: A Systematic Review of Prospective Studies” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547959/

 “Central obesity and breast cancer risk: a systematic review.” http://www.ncbi.nlm.nih.gov/pubmed/12916817

“Role of Obesity in the Risk of Breast Cancer: Lessons from Anthropometry” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575614/

“The molecular contribution of TNF-α in the link between obesity and breast cancer.” http://www.ncbi.nlm.nih.gov/pubmed/21165572

“Subcellular Localization of Cyclic AMP-Responsive Element Binding Protein-Regulated Transcription Coactivator 2 Provides a Link between Obesity and Breast Cancer in Postmenopausal Women” http://cancerres.aacrjournals.org/content/69/13/5392.long

 “An IL-6 link between obesity and cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23277002

 “Expression of microRNAs: potential molecular link between obesity, diabetes and cancer.” http://www.ncbi.nlm.nih.gov/pubmed/21767342

“Excess body weight and obesity–the link with gastrointestinal and hepatobiliary cancer.” http://www.ncbi.nlm.nih.gov/pubmed/21386810

“Obesity and gastrointestinal cancer.” http://www.ncbi.nlm.nih.gov/pubmed/20306531

 “The link between obesity and prostate cancer: the leptin pathway and therapeutic perspectives.” http://www.ncbi.nlm.nih.gov/pubmed/16344847

“The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523022/

 “Reducing the weight of cancer: mechanistic targets for breaking the obesity-carcinogenesis link.” http://www.ncbi.nlm.nih.gov/pubmed/18971125

“Overweight, obesity, and cancer risk.” http://www.ncbi.nlm.nih.gov/pubmed/12217794

“Obesity and cancer: the risks, science, and potential management strategies.” http://www.ncbi.nlm.nih.gov/pubmed/16053036

 “Overweight as an avoidable cause of cancer in Europe.” http://www.ncbi.nlm.nih.gov/pubmed/11169969

“Obesity management–an opportunity for cancer prevention.” http://www.ncbi.nlm.nih.gov/pubmed/19848061

 

Scales

Study Links Obesity, Cancer – News

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“Study Links Obesity, Cancer” http://www.cbsnews.com/video/watch/?id=3438650n

“‘Direct link’ between cancer and obesity” http://www.independent.co.uk/life-style/health-and-families/health-news/direct-link-between-cancer-and-obesity-398386.html

 “Obesity link to cancer” http://news.bbc.co.uk/2/hi/health/1334311.stm 

“Study supports link between obesity and higher incidence of cancer, poorer prognosis” http://medicalxpress.com/news/2012-10-link-obesity-higher-incidence-cancer.html

“Obesity-Cancer Link Detailed” http://www.the-scientist.com/?articles.view/articleNo/36204/title/Obesity-Cancer-Link-Detailed/

  “Obesity Linked to Many Cancer Cases in U.S.” http://www.webmd.com/cancer/news/20091105/obesity-linked-to-many-cancer-cases-in-us

“Increased obesity means increased cancer cases” http://thechart.blogs.cnn.com/2010/08/05/increased-obesity-means-increased-cancer-cases/

 “Obesity responsible for 100,000 cancer cases annually” http://edition.cnn.com/2009/HEALTH/11/05/obesity.cancer.link/

“Obesity is now the leading cause of cancer” http://www.nydailynews.com/life-style/health/obesity-leading-cancer-article-1.403496

“Obesity as a Cause of Endometrial Cancer: Gynecologic Oncologists to Add Perspective on New Report” http://www.newswise.com/articles/obesity-as-a-cause-of-endometrial-cancer-gynecologic-oncologists-to-add-perspective-on-new-report

“Obesity Helps Spur Cancer’s Growth, Mouse Study Suggests” http://healthyliving.msn.com/diseases/cancer/obesity-helps-spur-cancers-growth-mouse-study-suggests

“Obesity makes cancer harder to treat – researchers” http://abclocal.go.com/kabc/story?id=9167668

“Childhood Obesity linked to Colorectal Cancer” http://www.hivehealthmedia.com/childhood-obesity-linked-colorectal-cancer/

“Childhood obesity linked to bladder, urinary cancer” http://india.nydailynews.com/business/007bed187246683db27f00329afb7e2a/childhood-obesity-linked-to-bladder-urinary-cancer

“Study links childhood obesity to cancer in adults”  http://www.jpost.com/Health-and-Science/Study-links-childhood-obesity-to-cancer-in-adults 

 “Weight Gain and Obesity Linked with Endometrial Cancer Risk” http://news.yale.edu/2011/03/16/weight-gain-and-obesity-linked-endometrial-cancer-risk 

 “Athlone scientist reveals link between obesity and oesophageal cancer” http://www.westmeathindependent.ie/news/roundup/articles/2013/07/03/4016553-athlone-scientist-reveals-link-between-obesity-and-oesophageal-cancer/

“Scientists uncover key mechanism that links obesity and diabetes with cancer” http://www.news-medical.net/news/20130201/Scientists-uncover-key-mechanism-that-links-obesity-and-diabetes-with-cancer.aspx

 “Obesity Gene Linked To Skin Cancer” http://www.medicalnewstoday.com/articles/257159.php

“Obesity linked to liver cancer, gallbladder cancer” http://www.foodconsumer.org/newsite/Non-food/Disease/obesity_liver_cancer_gallbladder_cancer_0917120712.html

“Obesity linked to womb cancer rise” http://www.nursingtimes.net/nursing-practice/clinical-zones/public-health/obesity-linked-to-womb-cancer-rise/5017506.article

“Obesity Linked to Ovarian Cancer” http://abcnews.go.com/Health/Healthday/story?id=6581157&page=1

“Obesity genes linked to uterine cancer” http://news.vanderbilt.edu/2012/01/obesity-uterine-cancer/

 “Obesity Linked to Ovarian Cancer” http://articles.washingtonpost.com/2009-01-05/news/36784799_1_ovarian-cancer-obese-women-normal-weight-women

“Obesity Linked to More Advanced and More Aggressive Thyroid Cancer” http://www.familypracticenews.com/news/more-top-news/single-view/obesity-linked-to-more-advanced-and-more-aggressive-thyroid-cancer/30971304ec4a03ee4ce8abd728da736c.html

“Obesity Linked to Higher Risk for Aggressive Thyroid Cancer” http://www.medscape.com/viewarticle/764234

 “Pancreatic cancer and obesity linked” http://latimesblogs.latimes.com/booster_shots/2009/06/pancreatic-cancer-and-obesity-linked.html

 “Obesity linked to rise in kidney cancer” http://www.cancerresearchuk.org/cancer-info/news/archive/pressrelease/2002-09-21-obesity-linked-to-rise-in-kidney-cancer

 “Obesity fuels record rise in kidney cancers” http://www.nhs.uk/news/2012/03march/Pages/Obesity-fuels-kidney-cancer-rise.aspx

 “Obesity Linked to Prostate Cancer, Study Finds” http://www.webmd.com/prostate-cancer/news/20130423/obesity-linked-to-prostate-cancer-study-finds

“Obesity Raises Risk of Aggressive Prostate Cancer” http://www.renalandurologynews.com/obesity-raises-risk-of-aggressive-prostate-cancer/article/202883/#

 “Obesity increases men’s risk of dying from prostate cancer” http://www.nbcnews.com/health/obesity-increases-mens-risk-dying-prostate-cancer-6C9566874 

“Researchers discover link between obesity gene and breast cancer” http://medicalxpress.com/news/2011-05-link-obesity-gene-breast-cancer.html

 

 “Breast Cancer Linked to Obesity Gene, New Research Suggests” http://www.sciencedaily.com/releases/2011/05/110523124402.htm 

 

“Research Piles Up on Links Between Cancer and Obesity” http://blogs.wsj.com/health/2009/06/23/research-piles-up-on-links-between-cancer-and-obesity/

Cannabis exposure associated with weight reduction and β-cell protection in an obese rat model.

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“The aim of this study was to investigate the effect of an organic cannabis extract on β-cell secretory function in an in vivo diet-induced obese rat model and determine the associated molecular changes within pancreatic tissue…

These results suggest that the cannabis extract protects pancreatic islets against the negative effects of obesity.”

http://www.ncbi.nlm.nih.gov/pubmed/22421529

Cannabis and Δ9-tetrahydrocannabinol (THC) for weight loss?

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“Obesity is one of the highest preventable causes of morbidity and mortality in the developed world. It has been well known for a long time that exposure to cannabis produces an increase of appetite (a phenomenon referred to as the ‘munchies’). This phenomenon led to an exploration of the role of the endocannabinoid system in the regulation of obesity and associated metabolic syndrome.

This effort subsequently led to the development of a successful therapeutic approach for obesity that consisted of blocking the cannabinoid CB1 receptors using ligands such as Rimonabant in order to produce weight loss and improve metabolic profile. Despite being efficacious, Rimonabant was associated with increased rates of depression and anxiety and therefore removed from the market.

We recently discovered that the prevalence of obesity is paradoxically much lower in cannabis users as compared to non-users and that this difference is not accounted for by tobacco smoking status and is still present after adjusting for variables such as sex and age.

Here, we propose that this effect is directly related to exposure to the Δ(9)-tetrahydrocannabinol (THC) present in cannabis smoke.

We therefore propose the seemingly paradoxical hypothesis that THC or a THC/cannabidiol combination drug may produce weight loss and may be a useful therapeutic for the treatment of obesity and its complications.”

http://www.ncbi.nlm.nih.gov/pubmed/23410498

Cannabinoids.

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“Since the discovery of an endogenous cannabinoid system, research into the pharmacology and therapeutic potential of cannabinoids has steadily increased. Two subtypes of G-protein coupled cannabinoid receptors, CB(1) and CB(1), have been cloned and several putative endogenous ligands (endocannabinoids) have been detected during the past 15 years. The main endocannabinoids are arachidonoyl ethanolamide (anandamide) and 2-arachidonoyl glycerol (2-AG), derivatives of arachidonic acid, that are produced “on demand” by cleavage of membrane lipid precursors.

 Besides phytocannabinoids of the cannabis plant, modulators of the cannabinoid system comprise synthetic agonists and antagonists at the CB receptors and inhibitors of endocannabinoid degradation. Cannabinoid receptors are distributed in the central nervous system and many peripheral tissues, including immune system, reproductive and gastrointestinal tracts, sympathetic ganglia, endocrine glands, arteries, lung and heart. There is evidence for some non-receptor dependent mechanisms of cannabinoids and for endocannabinoid effects mediated by vanilloid receptors.

Properties of CB receptor agonists that are of therapeutic interest include analgesia, muscle relaxation, immunosuppression, anti-inflammation, antiallergic effects, improvement of mood, stimulation of appetite, antiemesis, lowering of intraocular pressure, bronchodilation, neuroprotection and antineoplastic effects. The current main focus of clinical research is their efficacy in chronic pain and neurological disorders. CB receptor antagonists are under investigation for medical use in obesity and nicotine addiction. Additional potential was proposed for the treatment of alcohol and heroine dependency, schizophrenia, conditions with lowered blood pressure, Parkinson’s disease and memory impairment in Alzheimer’s disease.”

http://www.ncbi.nlm.nih.gov/pubmed/16266285

Can Marijuana really be used to treat obesity?

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“Some of you may read that title and are subconsciously checking off another reason why pot is fucking awesome. Good for you, the perception of marijuana as  an illicit substance has been changing steadily over the course of the decades. Several opinion polls now indicate that a majority of Americans now support the legalization of marijuana, conclusively proving that people like to get high.

Aside from getting high and playing Xbox live, it now appears that marijuana use may actually reduce the likelihood of obesity in individuals who smoke pot regularly. According to a study recently published in the American Journal of Epidemiology, regular users of cannabis have a much lower prevalence of obesity than non users. Even when the researchers adjusted for other factors that can contribute to body fat such as tobacco use, age or gender, the correlation remained strong.”

Read more:http://scallywagandvagabond.com/2013/05/can-marijuana-really-be-used-to-treat-obesity/

Cannabis Compounds can Help Treat Obesity

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“Two cannabis compounds could be a new weapon in the fight against obesity, say researchers. Animal tests have shown these compounds can help treat type two diabetes while also lowering levels of cholesterol in the blood stream and fat in key organs like the liver.”

Cannabis Compounds can Help Treat Obesity

“Scientists also found the compounds also had an impact on the level of fat and its response to insulin, a hormone that controls blood sugar levels, the Telegraph reports.

THCV was also found to increase the animals’ sensitivity to insulin while also protecting the cells that produce insulin, allowing them to work better and for longer.

Steph Wright, director of research and development at GW Pharmaceuticals developing the drugs, said: “The results in animal models have been very encouraging. We are interested in how these drugs effect the fat distribution and utilisation in the body as a treatment for metabolic diseases…”

Mike Cawthorne, director of metabolic research at the University of Buckingham who has been conducting the animal studies, said: “Over all, it seems these molecules increase energy expenditure in the cells of the body by increasing the metabolism”.”
 
 

Study: Why Pot Smokers Are Skinnier

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“Marijuana users had smaller waists and scored higher across several measures of blood sugar regulation.”
 
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“”Marijuana use is associated with an acute increase in caloric intake,” goes the clinical jargon for popular lore. Still despite eating more while high (by some measures, over 600 extra calories per day), marijuana users’ extra intake doesn’t seem to be reflected in increased BMI. Indeed, studies have identified a reduced prevalence of obesity in the pot smoking community…
 

IMPLICATIONS: Although they’re not sure exactly how it happens, write the authors, these findings suggest that marijuana somehow works to improve insulin control, regulating body weight and perhaps explaining why marijuana users have a lower incidence of diabetes. Adding to the big questions — “can weed can treat obesity?” and “marijuana makes you skinny?!” — is the possibility that marijuana might be useful in helping people to manage their blood sugar.”

Read more: http://www.theatlantic.com/health/archive/2013/05/study-why-pot-smokers-are-skinnier/275846/

Does pot prevent obesity? What new marijuana study says – CBS News

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“Move over, fad diets. Scientists have identified something else that might keep off excess weight.

Smoking pot.

That’s right, marijuana users are less likely to be obese than their non-toking counterparts, according to a new study.

Doesn’t pot-smoking cause the munchies?

Actually, the researchers behind the study had been expecting to find that marijuana smokers would weigh more than non-users.

“Cannabis is supposed to increase appetite,” study author Dr. Yann Le Strat, a psychiatrist at Louis-Mourier Hospital in Colombes, France, told MSNBC.

 “We found that cannabis users are less likely to be obese than non-users…””

Read more: http://www.cbsnews.com/8301-504763_162-20102773-10391704/does-pot-prevent-obesity-what-new-marijuana-study-says/