Category Archives: Diabetes

The endocannabinoid system and its therapeutic exploitation.

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“The term ‘endocannabinoid’ – originally coined in the mid-1990s after the discovery of membrane receptors for the psychoactive principle in Cannabis, Delta9-tetrahydrocannabinol and their endogenous ligands – now indicates a whole signalling system that comprises cannabinoid receptors, endogenous ligands and enzymes for ligand biosynthesis and inactivation. This system seems to be involved in an ever-increasing number of pathological conditions. With novel products already being aimed at the pharmaceutical market little more than a decade since the discovery of cannabinoid receptors, the endocannabinoid system seems to hold even more promise for the future development of therapeutic drugs. We explore the conditions under which the potential of targeting the endocannabinoid system might be realized in the years to come.”  http://www.ncbi.nlm.nih.gov/pubmed/15340387

http://www.nature.com/nrd/journal/v3/n9/full/nrd1495.html

[The endocannabinoid system].

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“The endocannabinoid system is a physiological system, which is responsible for the control of glucose and lipid-metabolism, as well as for the regulation of the body weight.

 The endocannabinoid receptors are distributed both in the central and peripher nervous system.

Different studies provide evidence that an hyperactive endocannabinoid system is involved in the development of different cardiovascular risk factors.

The pharmacological blockade of these cannabinoid receptors may represent a new approach for cardiometabolic risk management.””

http://www.ncbi.nlm.nih.gov/pubmed/18548817 

Marijuana: The next diabetes drug? – CNN

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“Toking up may help marijuana users to stay slim and lower their risk of developing diabetes, according to the latest study, which suggests that cannabis compounds may help in controlling blood sugar.”

Marijuana may help control blood sugar and help users stay slimmer, researchers say.
 

“Although marijuana has a well-deserved reputation for increasing appetite via what stoners call “the munchies,” the new research, which was published in the American Journal of Medicine, is not the first to find that the drug has a two-faced relationship to weight.

Three prior studies have shown that marijuana users are less likely to be obese, have a lower risk for diabetes and have lower body-mass-index measurements. And these trends occurred despite the fact that they seemed to take in more calories. Why?”

Read more:http://www.cnn.com/2013/05/23/health/time-marijuana-diabetes/index.html 

Cannabis use associated with lower blood sugar – Fox News

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“A new study published in the American Journal of Medicine has revealed a potential benefit from the use of cannabis. The article, entitled “The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among U.S. Adults,” investigated the blood sugar-related effects of cannabis use among participants in the National Health and Nutrition Examination Survey from 2005 to 2010.”Marijuana

“The researchers found that subjects who were current cannabis users had lower levels of fasting insulin, lower levels of insulin resistance, smaller waist circumference, and higher levels of HDL cholesterol, which is known to reduce the risk of cardiovascular disease. This supported findings from earlier studies in which cannabis users showed improved weight, improved insulin resistance, and reduced incidence of diabetes, as compared with non-users.”

Read more: http://www.foxnews.com/health/2013/05/22/cannabis-use-associated-with-lower-blood-sugar/

Marijuana: The Next Diabetes Drug? – TIME

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“Toking up may help marijuana users to stay slim and lower their risk of developing diabetes, according to the latest study, which suggests that cannabis compounds may help in controlling blood sugar.”
 
Close Up Of Marijuana Leaf
 

“Although marijuana has a well-deserved reputation for increasing appetite via what stoners call “the munchies,” the new research, which was published in the American Journal of Medicine, is not the first to find that the drug has a two-faced relationship to weight. Three prior studies have shown that marijuana users are less likely to be obese, have a lower risk for diabetes and have lower body-mass-index measurements. And these trends occurred despite the fact that they seemed to take in more calories.”

Read more: http://healthland.time.com/2013/05/21/marijuana-the-next-diabetes-drug/

Cannabis Compounds can Help Treat Obesity

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“Two cannabis compounds could be a new weapon in the fight against obesity, say researchers. Animal tests have shown these compounds can help treat type two diabetes while also lowering levels of cholesterol in the blood stream and fat in key organs like the liver.”

Cannabis Compounds can Help Treat Obesity

“Scientists also found the compounds also had an impact on the level of fat and its response to insulin, a hormone that controls blood sugar levels, the Telegraph reports.

THCV was also found to increase the animals’ sensitivity to insulin while also protecting the cells that produce insulin, allowing them to work better and for longer.

Steph Wright, director of research and development at GW Pharmaceuticals developing the drugs, said: “The results in animal models have been very encouraging. We are interested in how these drugs effect the fat distribution and utilisation in the body as a treatment for metabolic diseases…”

Mike Cawthorne, director of metabolic research at the University of Buckingham who has been conducting the animal studies, said: “Over all, it seems these molecules increase energy expenditure in the cells of the body by increasing the metabolism”.”
 
 

Now they’re telling us smoking weed will also help fend off diabetes – MSN

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Man smoking a joint (©RL/KEYSTONE USA/Rex Features) 

“The magical weed that helps us stay trim, be less crazy, control seizures, cure Crohn’s, rescue the economy and make watching TV game shows more enjoyable is now being credited for possibly reducing the risk of diabetes, too. Analyzing statistics from the Centers for Disease Control and Prevention’s “National Health and Nutrition Examination Survey,” researchers uncovered the good news that current marijuana users had 16 percent lower fasting insulin levels and 17 percent lower levels of insulin resistance than their nonstoner friends.

Bonus: Scientists found that pot users also had slimmer waistlines and higher levels of “good” cholesterol.”

http://now.msn.com/marijuana-may-fight-diabetes-researchers-say 

Study: Why Pot Smokers Are Skinnier

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“Marijuana users had smaller waists and scored higher across several measures of blood sugar regulation.”
 
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“”Marijuana use is associated with an acute increase in caloric intake,” goes the clinical jargon for popular lore. Still despite eating more while high (by some measures, over 600 extra calories per day), marijuana users’ extra intake doesn’t seem to be reflected in increased BMI. Indeed, studies have identified a reduced prevalence of obesity in the pot smoking community…
 

IMPLICATIONS: Although they’re not sure exactly how it happens, write the authors, these findings suggest that marijuana somehow works to improve insulin control, regulating body weight and perhaps explaining why marijuana users have a lower incidence of diabetes. Adding to the big questions — “can weed can treat obesity?” and “marijuana makes you skinny?!” — is the possibility that marijuana might be useful in helping people to manage their blood sugar.”

Read more: http://www.theatlantic.com/health/archive/2013/05/study-why-pot-smokers-are-skinnier/275846/

Regular Marijuana Users May Be Skinnier, Have Better Blood Sugar Control: Study

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“People who regularly smoke marijuana may have better control of their blood sugar and may be skinnier than non-marijuana users, according to a new study.”

Marijuana Users Skinnier
 
“The research, published in the American Journal of Medicine, shows that people who reported regularly using marijuana had a lower risk of insulin resistance and had lower fasting insulin levels, compared with people who never used marijuana. Researchers also found an association between using marijuana and having a smaller waist circumference and higher levels of “good” HDL cholesterol, compared with non-users. The research was conducted by scientists from Beth Israel Deaconess Medical Center, the University of Nebraska and the Harvard School of Public Health.”
 
 

The Marijuana Diet? Scientists find link between pot smoking and weight loss

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“Low levels of insulin associated with users of marijuana. Vast ramifications seen.”

NR

 

“Smoking refer can help you better metabolize fats and carbs.

Go ahead, take another toke — the munchies don’t make you fat.

That’s the conclusion of a report published in the American Journal of Medicine, which found a strong correlation between marijuana use and a smaller waistband.

The study, conducted by researchers from the University of Nebraska, Harvard and Beth Israel Deaconess Medical Center, examined 4,657 adults, 579 of whom regularly smoked reefer.

“We found significant associations between marijuana use and smaller waist circumferences,” the researchers report.

Specifically, potheads had 16% lower levels of insulin than their non-smoking peers.

The hormone regulates metabolism of fat and carbs. The Atlantic noted that the findings perhaps explain why smokers of the wacky tobacky are less prone to diabetes.

Even people who had smoked weed in the past but did not currently puff showed similar, though less striking, results.”

 http://www.nydailynews.com/life-style/health/smoke-pot-thin-article-1.1345812