A randomized, double-blind clinical trial found that delta-9-tetrahydrocannabinol (THC) reduced tic severity in people with Tourette syndrome. Participants received THC for six weeks, and researchers reported improvement in several measures of motor and vocal tics compared with placebo. The study also found that THC was generally well tolerated, adding clinical evidence that the endocannabinoid system may play an important role in Tourette syndrome and tic control.
“Preliminary studies suggested that delta-9-tetrahydrocannabinol (THC), the major psychoactive ingredient of Cannabis sativa L., might be effective in the treatment of Tourette syndrome (TS).
This study was performed to investigate for the first time under controlled conditions, over a longer-term treatment period, whether THC is effective and safe in reducing tics in TS.
CONCLUSION:
Our results provide more evidence that THC is effective and safe in the treatment of tics. It, therefore, can be hypothesized that the central cannabinoid receptor system might play a role in TS pathology.”
https://www.ncbi.nlm.nih.gov/pubmed/12716250
“Our results provide more evidence that THC is effective and safe in the treatment of tics.” http://www.psychiatrist.com/jcp/article/Pages/2003/v64n04/v64n0417.aspx
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