Category Archives: Obesity

Can Marijuana really be used to treat obesity?

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“Some of you may read that title and are subconsciously checking off another reason why pot is fucking awesome. Good for you, the perception of marijuana as  an illicit substance has been changing steadily over the course of the decades. Several opinion polls now indicate that a majority of Americans now support the legalization of marijuana, conclusively proving that people like to get high.

Aside from getting high and playing Xbox live, it now appears that marijuana use may actually reduce the likelihood of obesity in individuals who smoke pot regularly. According to a study recently published in the American Journal of Epidemiology, regular users of cannabis have a much lower prevalence of obesity than non users. Even when the researchers adjusted for other factors that can contribute to body fat such as tobacco use, age or gender, the correlation remained strong.”

Read more:http://scallywagandvagabond.com/2013/05/can-marijuana-really-be-used-to-treat-obesity/

Cannabis Compounds can Help Treat Obesity

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“Two cannabis compounds could be a new weapon in the fight against obesity, say researchers. Animal tests have shown these compounds can help treat type two diabetes while also lowering levels of cholesterol in the blood stream and fat in key organs like the liver.”

Cannabis Compounds can Help Treat Obesity

“Scientists also found the compounds also had an impact on the level of fat and its response to insulin, a hormone that controls blood sugar levels, the Telegraph reports.

THCV was also found to increase the animals’ sensitivity to insulin while also protecting the cells that produce insulin, allowing them to work better and for longer.

Steph Wright, director of research and development at GW Pharmaceuticals developing the drugs, said: “The results in animal models have been very encouraging. We are interested in how these drugs effect the fat distribution and utilisation in the body as a treatment for metabolic diseases…”

Mike Cawthorne, director of metabolic research at the University of Buckingham who has been conducting the animal studies, said: “Over all, it seems these molecules increase energy expenditure in the cells of the body by increasing the metabolism”.”
 
 

Study: Why Pot Smokers Are Skinnier

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“Marijuana users had smaller waists and scored higher across several measures of blood sugar regulation.”
 
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“”Marijuana use is associated with an acute increase in caloric intake,” goes the clinical jargon for popular lore. Still despite eating more while high (by some measures, over 600 extra calories per day), marijuana users’ extra intake doesn’t seem to be reflected in increased BMI. Indeed, studies have identified a reduced prevalence of obesity in the pot smoking community…
 

IMPLICATIONS: Although they’re not sure exactly how it happens, write the authors, these findings suggest that marijuana somehow works to improve insulin control, regulating body weight and perhaps explaining why marijuana users have a lower incidence of diabetes. Adding to the big questions — “can weed can treat obesity?” and “marijuana makes you skinny?!” — is the possibility that marijuana might be useful in helping people to manage their blood sugar.”

Read more: http://www.theatlantic.com/health/archive/2013/05/study-why-pot-smokers-are-skinnier/275846/

Does pot prevent obesity? What new marijuana study says – CBS News

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“Move over, fad diets. Scientists have identified something else that might keep off excess weight.

Smoking pot.

That’s right, marijuana users are less likely to be obese than their non-toking counterparts, according to a new study.

Doesn’t pot-smoking cause the munchies?

Actually, the researchers behind the study had been expecting to find that marijuana smokers would weigh more than non-users.

“Cannabis is supposed to increase appetite,” study author Dr. Yann Le Strat, a psychiatrist at Louis-Mourier Hospital in Colombes, France, told MSNBC.

 “We found that cannabis users are less likely to be obese than non-users…””

Read more: http://www.cbsnews.com/8301-504763_162-20102773-10391704/does-pot-prevent-obesity-what-new-marijuana-study-says/

The Marijuana Diet? Scientists find link between pot smoking and weight loss

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“Low levels of insulin associated with users of marijuana. Vast ramifications seen.”

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“Smoking refer can help you better metabolize fats and carbs.

Go ahead, take another toke — the munchies don’t make you fat.

That’s the conclusion of a report published in the American Journal of Medicine, which found a strong correlation between marijuana use and a smaller waistband.

The study, conducted by researchers from the University of Nebraska, Harvard and Beth Israel Deaconess Medical Center, examined 4,657 adults, 579 of whom regularly smoked reefer.

“We found significant associations between marijuana use and smaller waist circumferences,” the researchers report.

Specifically, potheads had 16% lower levels of insulin than their non-smoking peers.

The hormone regulates metabolism of fat and carbs. The Atlantic noted that the findings perhaps explain why smokers of the wacky tobacky are less prone to diabetes.

Even people who had smoked weed in the past but did not currently puff showed similar, though less striking, results.”

 http://www.nydailynews.com/life-style/health/smoke-pot-thin-article-1.1345812

Could marijuana reduce diabetes risk? – Fox News

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“There’s an unexpected link between marijuana use and factors related to Type 2 diabetes that has medical researchers intrigued.”
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“Several studies have found that marijuana users take in more food calories than nonusers, but they still have lower rates of obesity and diabetes, and lower average body mass index (BMI) levels.

In a new study, researchers investigated what effects marijuana and its active ingredient tetrahydrocannabinol (THC) might have on people’s metabolism, especially insulin levels.

Insulin resistance an important risk factor for diabetes is a metabolic disorder that occurs when the body’s cells cannot properly intake insulin. The American Heart Association estimates 35 percent of U.S. adults have metabolic disorders that include insulin resistance.

To examine the link between THC and metabolism, researchers gathered the results of 4,657 adults from the National Health and Nutrition Examination Survey, a cross-sectional study administered annually by the Centers for Disease Control and Prevention.

Of the study’s participants, 579 were current marijuana users, 1,975 had used the drug in the past but not recently, and 2,103 had never tried marijuana. Researchers analyzed the participants’ fasting insulin levels, cholesterol levels, insulin resistance and waist sizes.

Multiple benefits seen”

Read more: http://www.foxnews.com/health/2013/05/16/could-marijuana-reduce-diabetes-risk/

Marijuana Helps Control Diabetes, Promotes Good Cholesterol, Leads to Lower Waist Size, and Lowers Bladder Cancer Risk, New Studies Show

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“Smoking marijuana has “remarkable” effect on diabetic problems and may lower risk of getting the disease, a study published on Wednesday states

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“This news comes a few days after a presentation at the annual conference of the American Urological Association that links heavy pot use to a much lower risk of bladder cancer…The more pot, the better: Researchers found that people who used marijuana more than 500 times a year were better off as far as bladder-cancer risk than those who used it infrequently.Whatever problems marijuana may cause, diabetes and bladder cancer apparently aren’t among them.”

 More: http://blogs.phoenixnewtimes.com/valleyfever/2013/05/marijuana_helps_control_diabet.php

The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults – The American Journal of Medicine

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“There are limited data regarding the relationship between cannabinoids and metabolic processes. Epidemiologic studies have found lower prevalence rates of obesity and diabetes mellitus in marijuana users compared with people who have never used marijuana, suggesting a relationship between cannabinoids and peripheral metabolic processes. To date, no study has investigated the relationship between marijuana use and fasting insulin, glucose, and insulin resistance…

Conclusions

We found that marijuana use was associated with lower levels of fasting insulin and HOMA-IR, and smaller waist circumference…”

http://www.amjmed.com/article/S0002-9343(13)00200-3/fulltext

Cannabis and Δ(9)-tetrahydrocannabinol (THC) for weight loss?

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“Obesity is one of the highest preventable causes of morbidity and mortality in the developed world. It has been well known for a long time that exposure to cannabis produces an increase of appetite (a phenomenon referred to as the ‘munchies’).

This phenomenon led to an exploration of the role of the endocannabinoid system in the regulation of obesity and associated metabolic syndrome. This effort subsequently led to the development of a successful therapeutic approach for obesity that consisted of blocking the cannabinoid CB(1) receptors using ligands such as Rimonabant in order to produce weight loss and improve metabolic profile. Despite being efficacious, Rimonabant was associated with increased rates of depression and anxiety and therefore removed from the market.

We recently discovered that the prevalence of obesity is paradoxically much lower in cannabis users as compared to non-users and that this difference is not accounted for by tobacco smoking status and is still present after adjusting for variables such as sex and age.

 Here, we propose that this effect is directly related to exposure to the Δ(9)-tetrahydrocannabinol (THC) present in cannabis smoke. We therefore propose the seemingly paradoxical hypothesis that THC or a THC/cannabidiol combination drug may produce weight loss and may be a useful therapeutic for the treatment of obesity and its complications.”

http://www.ncbi.nlm.nih.gov/pubmed/23410498

Endocannabinoids and obesity.

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“A safe and effective antiobesity drug is needed to combat the global obesity epidemic. The discovery of cannabinoids from medicinal herbs has revealed the endocannabinoid system (ECS) in animals and humans, which regulates various physiological activities such as feeding, thermogenesis, and body weight (BW).

Although cannabinoid receptors 1 (CB1) antagonists have shown antiobesity efficacies in animal models and in the clinic, they failed to establish as a treatment due to their psychological side effects.

 Recent studies indicate that CB1 in various peripheral tissues may mediate some of the therapeutic effects of CB1 antagonists, such as improved lipid and glucose homeostasis.

 It rationalizes the development of compounds with limited brain penetration, for minimizing the side effects while retaining the therapeutic efficacies. A survey of the literature has revealed some controversies about how the ECS affects obesity. This review summarizes the research progresses and discusses some future perspectives.”

http://www.ncbi.nlm.nih.gov/pubmed/23374723