Category Archives: Bladder Cancer

Bay Area Researchers Claim Cannabis Can Cure Cancer

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“Marijuana has been used for medicinal purposes–relieving stress and pain and fighting hunger and nausea–for centuries if not millennia. But now, a pair of doctors in San Francisco claim that they’ve compiled reliable data showing that a certain compound in cannabis–cannabidiol–may actually cure cancer.”

Bay Area Researchers Claim Cannabis Can Cure Cancer

“Unlike THC, the ingredient in marijuana that makes you feel stoned, cannabidiol is a non-toxic compound of the plant that has no psychoactive qualities, and it’s been the focus of an ongoing series of trials at the San Francisco-based California Pacific Medical Center. There, physicians Sean McAllister and Pierre Desprez claim they’ve successfully used cannabidiol to fight animal genes involved in the spread of cancer. Now they hope to be allowed to conduct anti-cancer research using cannabidiol on actual humans.”

Marijuana tied to lower bladder cancer risk

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“New research says smoking pot may be less likely to cause bladder cancer than smoking cigarettes.”

 

“The finding is potentially valuable, the study authors said, given the ongoing debate over legalising marijuana for medical purposes.”

More: http://www.health24.com/Medical/Cancer/News/Marijuana-tied-to-lower-bladder-cancer-risk-20130513

Smoking lots of marijuana lowers risk for bladder cancer, doctor says

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“A new study that spanned 11 years found that smoking marijuana may lower the chances of getting bladder cancer.”

  • ** FILE ** This Jan. 26, 2013, photo taken at a grow house in Denver shows a marijuana plants ready to be harvested. (AP Photo/Ed Andrieski)

“The study’s not been peer-reviewed yet, USA Today reported. It involved 83,000 men who smoked marijuana, cigarettes or both, Raw Story reported.

The findings, presented at the American Urological Association, found that men who smoked cigarettes increased their risks of bladder cancer, but that men who smoked marijuana only actually decreased their risks, Raw Story reported. Further, the study found that men who smoked both still have a higher chance of bladder cancer, but it was still a lower chance than those who smoked only cigarettes, Raw Story said.

“Cannabis use only was associated with a 45 percent reduction in bladder cancer incidence, and tobacco use only was associated with a 52 percent increase in bladder cancer,” the study’s author, Dr. Anil Thomas, said, Raw Story reported.

And smoking a lot of marijuana brought the greatest positive results.

Those who smoked marijuana more than 500 times a year had even less risk of bladder cancer than those who smoked the drug only once in a while, Raw Story reported.”

http://www.washingtontimes.com/news/2013/may/13/smoking-lots-marijuana-lowers-risk-bladder-cancer-/

Smoking marijuana lowers risk for bladder cancer

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“It’s enough to choke on, society tells us condoning any and all drug use is wrong.
If that’s true, why would there be the following?

Kaiser Permanente researchers studied 83,000 men ages 45-69 and found marijuana smokers are less likely to get bladder cancer than those who smoke cigarettes.

Smokers who used cannabis only, found a 45% decrease in the cancer opposed to those who used only tobacco. Those smokers found a 52% increase in the disease.

This is all based on smoking marijuana more than 500 times as opposed to the once or twice toker.

The study stems from findings at California Pacific Medical Center in San Francisco. The greenage could actually be the seed to stop the metastasis in many kinds of cancer, including breast, brain and cancer of the prostate.

Well munch on this; marijuana remains classified as the most dangerous controlled substance alongside heroin and LSD. This means the DEA has to approve any clinical trials of the drug. Yet our government obstructs that research.

In the midst of all this, Los Angeles councilman Bill Rosendahl posted this video announcing that his cancer is in remission, thanks to his use of medical marijuana.

Maybe all of this will cause the DEA to reconsider. After all, you want to cure cancer don’t you?”

http://newsfixnow.com/2013/05/17/smoking-marijuana-lowers-risk-for-bladder-cancer/

Cannabinoid receptor systems: therapeutic targets for tumour intervention.

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“The past decade has witnessed a rapid expansion of our understanding of the biological roles of cannabinoids and their cognate receptors. It is now certain that Delta9-tetrahydrocannabinol, the principle psychoactive component of the Cannabis sativa plant, binds and activates membrane receptors of the 7-transmembrane domain, G-protein-coupled superfamily.

Several putative endocannabinoids have since been identified, including anandamide, 2-arachidonyl glycerol and noladin ether. Synthesis of numerous cannabinomimetics has also greatly expanded the repertoire of cannabinoid receptor ligands with the pharmacodynamic properties of agonists, antagonists and inverse agonists.

Collectively, these ligands have proven to be powerful tools both for the molecular characterisation of cannabinoid receptors and the delineation of their intrinsic signalling pathways. Much of our understanding of the signalling mechanisms activated by cannabinoids is derived from studies of receptors expressed by tumour cells; hence, this review provides a succinct summary of the molecular pharmacology of cannabinoid receptors and their roles in tumour cell biology.

Moreover, there is now a genuine expectation that the manipulation of cannabinoid receptor systems may have therapeutic potential for a diverse range of human diseases. Thus, this review also summarises the demonstrated antitumour actions of cannabinoids and indicates possible avenues for the future development of cannabinoids as antitumour agents.” http://www.ncbi.nlm.nih.gov/pubmed/14640910

http://www.tandfonline.com/doi/abs/10.1517/14728222.7.6.749

The endocannabinoid system and its therapeutic exploitation.

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“The term ‘endocannabinoid’ – originally coined in the mid-1990s after the discovery of membrane receptors for the psychoactive principle in Cannabis, Delta9-tetrahydrocannabinol and their endogenous ligands – now indicates a whole signalling system that comprises cannabinoid receptors, endogenous ligands and enzymes for ligand biosynthesis and inactivation. This system seems to be involved in an ever-increasing number of pathological conditions. With novel products already being aimed at the pharmaceutical market little more than a decade since the discovery of cannabinoid receptors, the endocannabinoid system seems to hold even more promise for the future development of therapeutic drugs. We explore the conditions under which the potential of targeting the endocannabinoid system might be realized in the years to come.”  http://www.ncbi.nlm.nih.gov/pubmed/15340387

http://www.nature.com/nrd/journal/v3/n9/full/nrd1495.html

Marijuana Helps Control Diabetes, Promotes Good Cholesterol, Leads to Lower Waist Size, and Lowers Bladder Cancer Risk, New Studies Show

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“Smoking marijuana has “remarkable” effect on diabetic problems and may lower risk of getting the disease, a study published on Wednesday states

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“This news comes a few days after a presentation at the annual conference of the American Urological Association that links heavy pot use to a much lower risk of bladder cancer…The more pot, the better: Researchers found that people who used marijuana more than 500 times a year were better off as far as bladder-cancer risk than those who used it infrequently.Whatever problems marijuana may cause, diabetes and bladder cancer apparently aren’t among them.”

 More: http://blogs.phoenixnewtimes.com/valleyfever/2013/05/marijuana_helps_control_diabet.php

Active Component Of Marijuana Has Anti-Cancer Effects, Study Suggests

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“Guillermo Velasco and colleagues, at Complutense University, Spain, have provided evidence that suggests that cannabinoids such as the main active component of marijuana (THC) have anticancer effects on human brain cancer cells.

In the study, THC was found to induce the death of various human brain cancer cell lines and primary cultured human brain cancer cells by a process known as autophagy.

Consistent with the in vitro data, administration of THC to mice with human tumors decreased tumor growth and induced the tumor cells to undergo autophagy. As analysis of tumors from two patients with recurrent glioblastoma multiforme (a highly aggressive brain tumor) receiving intracranial THC administration showed signs of autophagy, the authors suggest that cannabinoid administration may provide a new approach to targeting human cancers.”  http://www.sciencedaily.com/releases/2009/04/090401181217.htm

“Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells” https://www.jci.org/articles/view/37948

 

Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma–Associated Herpesvirus-Infected Endothelium

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“Kaposi sarcoma is the most common neoplasm caused by Kaposi sarcoma–associated herpesvirus (KSHV). Current treatments for Kaposi sarcoma can inhibit tumor growth but are not able to eliminate KSHV from the host. When the host’s immune system weakens, KSHV begins to replicate again, and active tumor growth ensues. New therapeutic approaches are needed.

Cannabidiol (CBD), a plant-derived cannabinoid, exhibits promising antitumor effects without inducing psychoactive side effects. CBD is emerging as a novel therapeutic for various disorders, including cancer.

In this study, we investigated the effects of CBD both on the infection of endothelial cells (ECs) by KSHV and on the growth and apoptosis of KSHV-infected ECs, an in vitro model for the transformation of normal endothelium to Kaposi sarcoma….

Cannabidiol (CBD) was first isolated in 1940. It is a major component of the plant Cannabis sativa, which is also the source of Δ9-tetrahydrocannabinol (Δ9-THC). Due to its multiple biological activities, CBD has been identified as a potential clinical agent. Moreover, CBD affects these activities without the psychoactive side effects that typify Δ9-THC. Recent studies have documented the potential antitumorigenic properties of CBD in the treatment of various neoplasms, including breast cancer, lung cancer, bladder cancer, glioblastoma,and leukemia.CBD induces these effects through a variety of mechanisms and signaling pathways

CBD has been evaluated clinically for the treatment of various conditions, including anxiety, psychosis, and pain. In contrast to other members of the cannabinoid family, CBD has a strong safety profile and induces no psychotropic effects.Therefore, it has become an attractive agent in the search for new anticancer therapies.Our current study demonstrated that CBD preferentially enhanced apoptosis and inhibited the proliferation of KSHV-infected endothelial cells. This selective targeting of KSHV-induced neoplasia suggests that CBD may have a desirable therapeutic index when used to treat cancer. Moreover, a recent study demonstrated that CBD can be delivered effectively by nasal and transdermal routes, which may be particularly valuable for the treatment of Kaposi sarcoma oral or skin lesions.”

Full text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527984/

Cannabinoids for Cancer Treatment: Progress and Promise

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Cancer Research: 68 (2)

“Cannabinoid refers to a group of chemicals naturally found in the marijuana plant Cannabis sativa L. and includes compounds that are either structurally or pharmacologically similar to Δ(9)-tetrahydrocannabinol or those that bind to the cannabinoid receptors. Although anticancer effects of cannabinoids were shown as early as 1975 in Lewis lung carcinoma, renewed interest was generated little after the discovery of the cannabinoid system and cloning of the specific cannabinoid receptors.

Cannabinoids are a class of pharmacologic compounds that offer potential applications as antitumor drugs, based on the ability of some members of this class to limit inflammation, cell proliferation, and cell survival. In particular, emerging evidence suggests that agonists of cannabinoid receptors expressed by tumor cells may offer a novel strategy to treat cancer. Here, we review recent work that raises interest in the development and exploration of potent, nontoxic, and nonhabit forming cannabinoids for cancer therapy.”

Full Text: http://cancerres.aacrjournals.org/content/68/2/339.long