Tag Archives: cancer

Upregulated expression of CAP1 is associated with tumor migration and metastasis in hepatocellular carcinoma.

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“Hepatocellular carcinoma (HCC) is one of the most common cancers that exhibits high incidences of intrahepatic metastasis and tumor recurrence.

Adenylate cyclase-associated protein 1 (CAP1)… was recently reported to play a role in cell motility and the pathology of pancreatic cancer. In this study, we examined a potential role of CAP1 in HCC progression, and found that CAP1 was overexpressed in HCC specimens…

Collectively, our results indicated that upregulated expression of CAP1 might contribute heavily to the metastasis of HCC.”

http://www.ncbi.nlm.nih.gov/pubmed/24359721

 http://www.thctotalhealthcare.com/category/hepatocellular-carcinoma-hcc/

Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8.

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“… we have reported here for the first time the potent and efficacious modulatory effects by some phytocannabinoids on TRPA1- and TRPM8-mediated [Ca2+]ielevation…

Our findings suggest that phytocannabinoids and cannabis extracts exert some of their pharmacological actions also by interacting with TRPA1 and TRPM8 channels, with potential implications for the treatment of pain and cancer.”

http://jpet.aspetjournals.org/content/325/3/1007.long

Study: Marijuana’s Active Ingredient May Shrink Cancerous Tumors – FoxNews

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“The active ingredient in marijuana appears to reduce tumor growth…

The researchers showed giving THC to mice with cancer decreased tumor growth and killed cells off in a process called autophagy.

“Our findings support that safe, therapeutically efficacious doses of THC may be reached in cancer patients,” Guillermo Velasco of Complutense University in Madrid and colleagues reported in the Journal of Clinical Investigation…

Other research has shown benefits, such as staving off Alzheimer’s, and many doctors view THC as a valuable way to treat weight loss associated with AIDS, and nausea and vomiting associated with chemotherapy in cancer patients.

Velasco and his team’s study included an analysis of two tumors from two people with a highly aggressive brain cancer which showed signs of autophagy after receiving THC.

The researchers said the findings could pave the way for cannabinoid-based drugs to treat cancer…”

More: http://www.foxnews.com/story/2009/04/02/study-marijuana-active-ingredient-may-shrink-cancerous-tumors/

“Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells… These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673842/

Critical appraisal of the potential use of cannabinoids in cancer management

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“Cannabinoids have been attracting a great deal of interest as potential anticancer agents. Originally derived from the plant Cannabis sativa, there are now a number of endo-, phyto- and synthetic cannabinoids available. This review summarizes the key literature to date around the actions, antitumor activity, and mechanisms of action for this broad range of compounds…

Two therapeutic avenues exist for the development of cannabinoids as anticancer agents. As antiemetic and analgesic compounds, this class of compounds has been explored in terms of palliative care. More recently, cannabinoid agonists and antagonists have been screened for potential direct antitumorigenic properties.

… results suggest that overall the cannabinoids affect multiple cellular signaling pathways, which means they have the potential to decrease cancer development, growth, and metastasis.

Overall, the cannabinoids may show future promise in the treatment of cancer, but there are many significant hurdles to be overcome. There is much still to be learned about the action of the cannabinoids and the endocannabinoid system.

It is a distinct possibility that the cannabinoids may have a place in the future treatment of cancer.”

Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770515/

Marijuana’s Active Ingredient Targets Deadly Brain Cancer – WebMD

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“If results of a recent rat study hold true in human trials, marijuana could be the treatment of choice for patients with malignant glioma — an especially aggressive and often fatal form of brain cancer.

 No, rats haven’t started smoking pot. But when researchers injected tumorous animals with cannabinoids — the drug’s active ingredient — about a third of them went into remission, and another third lived significantly longer than untreated rats.

The findings appear in the March issue of the journal Nature Medicine…

According to lead researcher Manuel Guzmán, PhD, his team’s previous studies showed that cannabinoids could stop growth and kill cancer cells but did not harm normal cells. The current work examined the action behind this effect and whether it would also work in living animals…

The researchers first caused tumors in the brains of 18 rats. They then injected the animals over the course of seven days with either a natural or artificial cannabinoid, or a placebo for comparison. Additional groups of healthy, tumor-free rats also received the various treatments…

All of the untreated animals with tumors died between days 12 and 18, but those treated with the cannabinoids lived much longer, and had significantly smaller tumors…

There were no negative side effects at all in the healthy animals receiving treatment.”

More:http://www.webmd.com/cancer/news/20000228/marijuanas-active-ingredient-targets-deadly-brain-cancer

“Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation” http://www.nature.com/nm/journal/v6/n3/abs/nm0300_313.html

Marijuana May Stall Brain Tumor Growth – WebMD

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“Active Ingredient in Marijuana Inhibits Cancer Growth in Early Study.
 
The active ingredient in marijuana may help fight brain tumors, a new study suggests.
 

Researchers say the cannabinoids found in marijuana may aid in brain tumor treatment by targeting the genes needed for the tumors to sprout blood vessels and grow.

Their study showed that cannabinoids inhibited genes needed for the production of vascular growth factor (VEGF) in laboratory mice with glioma brain tumors and two patients with late-stage glioblastoma multiforme, a form of brain cancer.

VEGF is a protein that stimulates blood vessels to grow. Tumors need an abundant blood supply because they generally grow rapidly. So when VEGF is blocked, tumors starve from lack of blood supply and nutrients.

Blocking of VEGF constitutes one of the most promising tumor-fighting approaches currently available, says researcher Manuel Guzman, professor of biochemistry and molecular biology, at the Complutense University in Madrid, Spain, in a news release.”

More:http://www.webmd.com/cancer/news/20040815/marijuana-stall-brain-tumor-growth 

“Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas”:  http://cancerres.aacrjournals.org/content/64/16/5617.long

 

Unhappy Couple
 

Link between obesity and cancer – Science

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“Link between obesity and cancer” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670342/

“Biological mechanisms linking obesity and cancer risk: new perspectives.” http://www.ncbi.nlm.nih.gov/pubmed/19824817

“Overweight/obesity and cancer genesis: more than a biological link.” http://www.ncbi.nlm.nih.gov/pubmed/18035514

“The Obesity-Cancer Link: Lessons Learned from a Fatless Mouse” http://cancerres.aacrjournals.org/content/67/6/2391.long

“Epidemiology and pathophysiology of obesity as cause of cancer.” http://www.ncbi.nlm.nih.gov/pubmed/17299670

“Obesity and cancer.” http://www.ncbi.nlm.nih.gov/pubmed/19924603

“Obesity and cancer: pathophysiological and biological mechanisms.” http://www.ncbi.nlm.nih.gov/pubmed/18465361

“Obesity and cancer risk: evidence, mechanisms, and recommendations” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476838/

 “The growing challenge of obesity and cancer: an inflammatory issue.” http://www.ncbi.nlm.nih.gov/pubmed/21793838

“Growth Signals, Inflammation, and Vascular Perturbations, Mechanistic Links Between Obesity, Metabolic Syndrome, and Cancer” http://atvb.ahajournals.org/content/32/8/1766.long

  “Obesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issue” http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2012.06737.x/full

 “Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.” http://www.ncbi.nlm.nih.gov/pubmed/23803760

“Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms” http://www.nature.com/nrc/journal/v4/n8/full/nrc1408.html

“Overweight and obesity: a review of their relationship to metabolic syndrome, cardiovascular disease, and cancer in South America.” http://www.ncbi.nlm.nih.gov/pubmed/23452284

“Cytokines, obesity, and cancer: new insights on mechanisms linking obesity to cancer risk and progression.” http://www.ncbi.nlm.nih.gov/pubmed/23121183

“Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555202/

“Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23622129

“Obesity, energy balance, and cancer: new opportunities for prevention.” http://www.ncbi.nlm.nih.gov/pubmed/23034147

 “Obesity and colorectal cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23481261

“Obesity and Risk of Colorectal Cancer: A Meta-analysis of 31 Studies with 70,000 Events” http://cebp.aacrjournals.org/content/16/12/2533.long

 “Obesity and Risk of Colorectal Cancer: A Systematic Review of Prospective Studies” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547959/

 “Central obesity and breast cancer risk: a systematic review.” http://www.ncbi.nlm.nih.gov/pubmed/12916817

“Role of Obesity in the Risk of Breast Cancer: Lessons from Anthropometry” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575614/

“The molecular contribution of TNF-α in the link between obesity and breast cancer.” http://www.ncbi.nlm.nih.gov/pubmed/21165572

“Subcellular Localization of Cyclic AMP-Responsive Element Binding Protein-Regulated Transcription Coactivator 2 Provides a Link between Obesity and Breast Cancer in Postmenopausal Women” http://cancerres.aacrjournals.org/content/69/13/5392.long

 “An IL-6 link between obesity and cancer.” http://www.ncbi.nlm.nih.gov/pubmed/23277002

 “Expression of microRNAs: potential molecular link between obesity, diabetes and cancer.” http://www.ncbi.nlm.nih.gov/pubmed/21767342

“Excess body weight and obesity–the link with gastrointestinal and hepatobiliary cancer.” http://www.ncbi.nlm.nih.gov/pubmed/21386810

“Obesity and gastrointestinal cancer.” http://www.ncbi.nlm.nih.gov/pubmed/20306531

 “The link between obesity and prostate cancer: the leptin pathway and therapeutic perspectives.” http://www.ncbi.nlm.nih.gov/pubmed/16344847

“The relationship between obesity and prostate cancer: from genetics to disease treatment and prevention” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523022/

 “Reducing the weight of cancer: mechanistic targets for breaking the obesity-carcinogenesis link.” http://www.ncbi.nlm.nih.gov/pubmed/18971125

“Overweight, obesity, and cancer risk.” http://www.ncbi.nlm.nih.gov/pubmed/12217794

“Obesity and cancer: the risks, science, and potential management strategies.” http://www.ncbi.nlm.nih.gov/pubmed/16053036

 “Overweight as an avoidable cause of cancer in Europe.” http://www.ncbi.nlm.nih.gov/pubmed/11169969

“Obesity management–an opportunity for cancer prevention.” http://www.ncbi.nlm.nih.gov/pubmed/19848061

 

Scales

Study Links Obesity, Cancer – News

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“Study Links Obesity, Cancer” http://www.cbsnews.com/video/watch/?id=3438650n

“‘Direct link’ between cancer and obesity” http://www.independent.co.uk/life-style/health-and-families/health-news/direct-link-between-cancer-and-obesity-398386.html

 “Obesity link to cancer” http://news.bbc.co.uk/2/hi/health/1334311.stm 

“Study supports link between obesity and higher incidence of cancer, poorer prognosis” http://medicalxpress.com/news/2012-10-link-obesity-higher-incidence-cancer.html

“Obesity-Cancer Link Detailed” http://www.the-scientist.com/?articles.view/articleNo/36204/title/Obesity-Cancer-Link-Detailed/

  “Obesity Linked to Many Cancer Cases in U.S.” http://www.webmd.com/cancer/news/20091105/obesity-linked-to-many-cancer-cases-in-us

“Increased obesity means increased cancer cases” http://thechart.blogs.cnn.com/2010/08/05/increased-obesity-means-increased-cancer-cases/

 “Obesity responsible for 100,000 cancer cases annually” http://edition.cnn.com/2009/HEALTH/11/05/obesity.cancer.link/

“Obesity is now the leading cause of cancer” http://www.nydailynews.com/life-style/health/obesity-leading-cancer-article-1.403496

“Obesity as a Cause of Endometrial Cancer: Gynecologic Oncologists to Add Perspective on New Report” http://www.newswise.com/articles/obesity-as-a-cause-of-endometrial-cancer-gynecologic-oncologists-to-add-perspective-on-new-report

“Obesity Helps Spur Cancer’s Growth, Mouse Study Suggests” http://healthyliving.msn.com/diseases/cancer/obesity-helps-spur-cancers-growth-mouse-study-suggests

“Obesity makes cancer harder to treat – researchers” http://abclocal.go.com/kabc/story?id=9167668

“Childhood Obesity linked to Colorectal Cancer” http://www.hivehealthmedia.com/childhood-obesity-linked-colorectal-cancer/

“Childhood obesity linked to bladder, urinary cancer” http://india.nydailynews.com/business/007bed187246683db27f00329afb7e2a/childhood-obesity-linked-to-bladder-urinary-cancer

“Study links childhood obesity to cancer in adults”  http://www.jpost.com/Health-and-Science/Study-links-childhood-obesity-to-cancer-in-adults 

 “Weight Gain and Obesity Linked with Endometrial Cancer Risk” http://news.yale.edu/2011/03/16/weight-gain-and-obesity-linked-endometrial-cancer-risk 

 “Athlone scientist reveals link between obesity and oesophageal cancer” http://www.westmeathindependent.ie/news/roundup/articles/2013/07/03/4016553-athlone-scientist-reveals-link-between-obesity-and-oesophageal-cancer/

“Scientists uncover key mechanism that links obesity and diabetes with cancer” http://www.news-medical.net/news/20130201/Scientists-uncover-key-mechanism-that-links-obesity-and-diabetes-with-cancer.aspx

 “Obesity Gene Linked To Skin Cancer” http://www.medicalnewstoday.com/articles/257159.php

“Obesity linked to liver cancer, gallbladder cancer” http://www.foodconsumer.org/newsite/Non-food/Disease/obesity_liver_cancer_gallbladder_cancer_0917120712.html

“Obesity linked to womb cancer rise” http://www.nursingtimes.net/nursing-practice/clinical-zones/public-health/obesity-linked-to-womb-cancer-rise/5017506.article

“Obesity Linked to Ovarian Cancer” http://abcnews.go.com/Health/Healthday/story?id=6581157&page=1

“Obesity genes linked to uterine cancer” http://news.vanderbilt.edu/2012/01/obesity-uterine-cancer/

 “Obesity Linked to Ovarian Cancer” http://articles.washingtonpost.com/2009-01-05/news/36784799_1_ovarian-cancer-obese-women-normal-weight-women

“Obesity Linked to More Advanced and More Aggressive Thyroid Cancer” http://www.familypracticenews.com/news/more-top-news/single-view/obesity-linked-to-more-advanced-and-more-aggressive-thyroid-cancer/30971304ec4a03ee4ce8abd728da736c.html

“Obesity Linked to Higher Risk for Aggressive Thyroid Cancer” http://www.medscape.com/viewarticle/764234

 “Pancreatic cancer and obesity linked” http://latimesblogs.latimes.com/booster_shots/2009/06/pancreatic-cancer-and-obesity-linked.html

 “Obesity linked to rise in kidney cancer” http://www.cancerresearchuk.org/cancer-info/news/archive/pressrelease/2002-09-21-obesity-linked-to-rise-in-kidney-cancer

 “Obesity fuels record rise in kidney cancers” http://www.nhs.uk/news/2012/03march/Pages/Obesity-fuels-kidney-cancer-rise.aspx

 “Obesity Linked to Prostate Cancer, Study Finds” http://www.webmd.com/prostate-cancer/news/20130423/obesity-linked-to-prostate-cancer-study-finds

“Obesity Raises Risk of Aggressive Prostate Cancer” http://www.renalandurologynews.com/obesity-raises-risk-of-aggressive-prostate-cancer/article/202883/#

 “Obesity increases men’s risk of dying from prostate cancer” http://www.nbcnews.com/health/obesity-increases-mens-risk-dying-prostate-cancer-6C9566874 

“Researchers discover link between obesity gene and breast cancer” http://medicalxpress.com/news/2011-05-link-obesity-gene-breast-cancer.html

 

 “Breast Cancer Linked to Obesity Gene, New Research Suggests” http://www.sciencedaily.com/releases/2011/05/110523124402.htm 

 

“Research Piles Up on Links Between Cancer and Obesity” http://blogs.wsj.com/health/2009/06/23/research-piles-up-on-links-between-cancer-and-obesity/

Cannabis Kills Cancer Cells

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“Marijuana also found to prevent pain associated with chemotherapy”

Cannabis Kills Cancer Cells

“Studies in Spain have shown findings that Tetrahydrocannabinol (THC), the active ingredient found in marijuana, can induce the death of brain cancer cells, according to scientist Guillermo Velasco and his research team from the School of Biology at Complutense University in Madrid.

In a laboratory study where mice were “engineered” to carry three varying kinds of human cancer tumor grafts, THC was introduced into the brain, triggering a self-digestion development on a cellular level, known as “autophagy.” Within this process, the research team managed to isolate the particular activation route from which this process evolved.

The research team was also conducting clinical trials in concert, on two consenting brain cancer patients, said to be suffering from a rapidly aggressive form of cancer, known as “recurrent glioblastoma multiforme.”

The team, using electron microscopes to analyze brain tissue extracted before and after the 26 to 30-day regime, found that the THC had eradicated cancer cells, leaving the healthy cells undamaged.

The findings can now lend themselves to future design in newer cancer therapies, using the concept of autophagy activation.”

More: http://guardianlv.com/2013/08/cannabis-kills-cancer-cells/

THC is anticarcinogenic: marijuana may be cancer cure!

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“Toxicology and Carcinogenesis Studies of 1-Trans-[Delta.sup.9]-Tetrahydrocannabinol

Summation of above:

“Thus, in our studies, rats and mice that received THC for 2 years exhibited body weight reductions, enhanced survival rates, and decreased tumor incidences in several sites, mainly organs under hormonal control. These earlier experimental carcinogenesis results on THC clearly lend further validity to the notion that cannabinoids may indeed be anticarcinogenic.””

 link
http://www.thefreelibrary.com/Antitumor+Effects+of+THC-a06814…

http://www.sodahead.com/united-states/thc-is-anticarcinogenic-marijuana-may-be-cancer-cure/question-1031413/?link=ibaf&q=THC+anti-carcinogenic+news