No ‘Smoking’ Gun: Research Indicates Teen Marijuana Use Does Not Predict Drug, Alcohol Abuse

“Marijuana is not a “gateway” drug that predicts or eventually leads to substance abuse, suggests a 12-year University of Pittsburgh study. Moreover, the study’s findings call into question the long-held belief that has shaped prevention efforts and governmental policy for six decades and caused many a parent to panic upon discovering a bag of pot in their child’s bedroom.

The Pitt researchers tracked 214 boys beginning at ages 10-12, all of whom eventually used either legal or illegal drugs. When the boys reached age 22, they were categorized into three groups: those who used only alcohol or tobacco, those who started with alcohol and tobacco and then used marijuana (gateway sequence) and those who used marijuana prior to alcohol or tobacco (reverse sequence).

Nearly a quarter of the study population who used both legal and illegal drugs at some point — 28 boys — exhibited the reverse pattern of using marijuana prior to alcohol or tobacco, and those individuals were no more likely to develop a substance use disorder than those who followed the traditional succession of alcohol and tobacco before illegal drugs, according to the study, which appears in this month’s issue of the American Journal of Psychiatry.

“The gateway progression may be the most common pattern, but it’s certainly not the only order of drug use,” said Ralph E. Tarter, Ph.D., professor of pharmaceutical sciences at the University of Pittsburgh School of Pharmacy and lead author of the study. “In fact, the reverse pattern is just as accurate for predicting who might be at risk for developing a drug dependence disorder.”

In addition to determining whether the gateway hypothesis was a better predictor of substance abuse than competing theories, the investigators sought to identify characteristics that distinguished users in the gateway sequence from those who took the reverse path. Out of the 35 variables they examined, only three emerged to be differentiating factors: Reverse pattern users were more likely to have lived in poor physical neighborhood environments, had more exposure to drugs in their neighborhoods and had less parental involvement as young children. Most importantly, a general inclination for deviance from sanctioned behaviors, which can become evident early in childhood, was strongly associated with all illicit drug use, whether it came in the gateway sequence, or the reverse.

While the gateway theory posits that each type of drug is associated with certain specific risk factors that cause the use of subsequent drugs, such as cigarettes or alcohol leading to marijuana, this study’s findings indicate that environmental aspects have stronger influence on which type of substance is used. That is, if it’s easier for a teen to get his hands on marijuana than beer, then he’ll be more likely to smoke pot. This evidence supports what’s known as the common liability model, an emerging theory that states the likelihood that someone will transition to the use of illegal drugs is determined not by the preceding use of a particular drug but instead by the user’s individual tendencies and environmental circumstances.

“The emphasis on the drugs themselves, rather than other, more important factors that shape a person’s behavior, has been detrimental to drug policy and prevention programs,” Dr. Tarter said. “To become more effective in our efforts to fight drug abuse, we should devote more attention to interventions that address these issues, particularly to parenting skills that shape the child’s behavior as well as peer and neighborhood environments.”

Indeed, according to the study, interventions focusing on behavior modification may be more effective prevention tactics than current anti-drug initiatives. For example, providing guidance to parents — particularly those in high-risk neighborhoods — on how to boost their caregiving skills and foster bonding with their children, could have a measurable effect on a child’s likelihood to smoke marijuana. Also, early identification of children who exhibit antisocial tendencies could allow for interventions before drug use even begins.

Although this research has significant implications for drug abuse prevention approaches, Dr. Tarter notes that the study has some limitations. First, as only male behaviors were studied, further investigation should explore if the results apply to women as well. Also, the examination of behaviors in phases beyond alcohol and marijuana consumption in the gateway series will be necessary.

Other study authors include Michael Vanyukov, Ph.D., and Maureen Reynolds, Ph.D., and Levent Kirisci, Ph.D., also of the University of Pittsburgh School of Pharmacy; and Duncan Clark, M.D., Ph.D., of the University of Pittsburgh School of Medicine. The research was funded by the National Institute on Drug Abuse.”

http://www.sciencedaily.com/releases/2006/12/061204123422.htm

Can Marijuana really be used to treat obesity?

“Some of you may read that title and are subconsciously checking off another reason why pot is fucking awesome. Good for you, the perception of marijuana as  an illicit substance has been changing steadily over the course of the decades. Several opinion polls now indicate that a majority of Americans now support the legalization of marijuana, conclusively proving that people like to get high.

Aside from getting high and playing Xbox live, it now appears that marijuana use may actually reduce the likelihood of obesity in individuals who smoke pot regularly. According to a study recently published in the American Journal of Epidemiology, regular users of cannabis have a much lower prevalence of obesity than non users. Even when the researchers adjusted for other factors that can contribute to body fat such as tobacco use, age or gender, the correlation remained strong.”

Read more:http://scallywagandvagabond.com/2013/05/can-marijuana-really-be-used-to-treat-obesity/

Cannabis Compounds can Help Treat Obesity

“Two cannabis compounds could be a new weapon in the fight against obesity, say researchers. Animal tests have shown these compounds can help treat type two diabetes while also lowering levels of cholesterol in the blood stream and fat in key organs like the liver.”

 Cannabis Compounds can Help Treat Obesity

“Scientists also found the compounds also had an impact on the level of fat and its response to insulin, a hormone that controls blood sugar levels, the Telegraph reports.

THCV was also found to increase the animals’ sensitivity to insulin while also protecting the cells that produce insulin, allowing them to work better and for longer.

Steph Wright, director of research and development at GW Pharmaceuticals developing the drugs, said: “The results in animal models have been very encouraging. We are interested in how these drugs effect the fat distribution and utilisation in the body as a treatment for metabolic diseases…”

Mike Cawthorne, director of metabolic research at the University of Buckingham who has been conducting the animal studies, said: “Over all, it seems these molecules increase energy expenditure in the cells of the body by increasing the metabolism”.”
 
 

Does pot prevent obesity? What new marijuana study says – CBS News

 

“Move over, fad diets. Scientists have identified something else that might keep off excess weight.

Smoking pot.

That’s right, marijuana users are less likely to be obese than their non-toking counterparts, according to a new study.

Doesn’t pot-smoking cause the munchies?

Actually, the researchers behind the study had been expecting to find that marijuana smokers would weigh more than non-users.

“Cannabis is supposed to increase appetite,” study author Dr. Yann Le Strat, a psychiatrist at Louis-Mourier Hospital in Colombes, France, told MSNBC.

 “We found that cannabis users are less likely to be obese than non-users…””

Read more: http://www.cbsnews.com/8301-504763_162-20102773-10391704/does-pot-prevent-obesity-what-new-marijuana-study-says/

Regular Cannabis Users ‘Have Better Blood Sugar Control’

“People who regularly use cannabis have better blood sugar control than those who do not, providing implications for use of the drug in diabetic control.”

Cannabis users have lower blood sugar levels than non-users (Reuters)

“Research published in the American Journal of Medicine found current marijuana users are less likely to be insulin resistant and have significantly lower fasting insulin levels, even after patients with diabetes were excluded from the study. 

The ream found cannabis users’ fasting insulin levels were 16% lower than non-users…

Cannabis in becoming increasingly used for medical purposes, with the active ingredient tetrahydrocannabinol (THC) approved in the US as a treatment for the side effect of chemotherapy. It is legal for recreational use in two states and 19 for medical use.

The researchers looked at data obtained through the National Health and Nutrition Survey between 2005 and 2010.

They looked at questionnaires from 4,657 people, of which 579 were regular cannabis users, 1,975 had used marijuana but not regularly and 2,103 had never used the drug.

Insulin and glucose were measured through blood samples after a nine hour fast and insulin resistance was calculated.

The team found that people who had used cannabis in the last month had lower levels of fasting insulin and insulin resistance and higher levels of high-density lipoprotein cholesterol (HDL-C), which is associated with better cardiovascular health…”

Read more: http://www.ibtimes.co.uk/articles/467817/20130515/cannabis-marijuana-lower-blood-sugar-levels-diabetes.htm

Better Diabetic Control Seen In Marijuana Users

 
“Marijuana (Cannabis sativa) has been used ritualistically for thousands of years and, for centuries, has been used as a way to relieve pain, improve mood and increase appetite. While several studies have given the wacky tobacky, as it is referred to by some, a bad rap, others have shown some positives. One such positive is the role marijuana may play in preventing PTSD symptoms from occurring. In another newly published paper, researchers have shown that regular marijuana may help with diabetes control.

Investigators from Beth Israel Deaconess Medical Center (BIDMC) in Boston, published a paper in the current issue of the The American Journal of Medicine detailing how marijuana users had significantly lower fasting insulin and were less likely to be insulin resistant than those who did not smoke the weed. The researchers noted that this remained true even after excluding patients who had a diagnosis of diabetes…

For the current study, the BIDMC team analyzed data obtained from the National Health and Nutrition Survey (NHANES) between 2005 and 2010. Their research included data from 4,657 patients who completed a drug use questionnaire. Of these, 579 were current marijuana users, 1,975 had used it in the past, and 2,103 had never used the drug recreationally or medicinally. The team measured fasting insulin and glucose via blood samples after patients fasted for nine hours. The team also evaluated insulin resistance via homeostasis model assessment of insulin resistance (HOMA-IR).

The researchers found that those who reported using marijuana in the past month had lower levels of fasting insulin and HOMA-IR and higher levels of HDL “good” cholesterol. Those who reported not using marijuana at any time in the last month had weaker associations, suggesting to the team that marijuana use on insulin and insulin resistance exists only during recent use. Current users had 16 percent lower fasting insulin levels than those who reported never using marijuana.

The team also found a link between marijuana use and waistlines. While diabetes is often associated with larger waistlines, the study group found that marijuana users most often had smaller waistlines.”

Read more: http://www.redorbit.com/news/health/1112847494/marijuana-use-helps-manage-insulin-diabetic-control-051513/

Marijuana for Diabetic Control

“For centuries, cannabis sativa, more commonly known as marijuana, has been used as a folk remedy to relieve pain, improve mood, and increase appetite…

Much of what we know about cannabis comes from folktales and limited clinical observation. It was in this context that I was pleased to receive the submission published in this edition of The American Journal of Medicine, entitled “The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance Among US Adults.” This epidemiologic, observational study demonstrated that among diabetic patients who admitted to using marijuana, insulin resistance was decreased and diabetic control was improved. Penner et al analyzed data obtained during the National Health and Nutrition Survey between 2005 and 2010. They studied data from 4657 patients, of whom 579 were current users of cannabis, 1975 used cannabis in the past but were not current users, and 2103 had never inhaled or ingested marijuana. These patients had fasting insulin and glucose levels measured along with a test for insulin resistance.

 Remarkably, fasting insulin levels were reduced in current cannabis users but not in former or never users. Two additional observations were that waist circumference was smaller and high-density lipoprotein cholesterol blood levels were higher in current cannabis users.

These are indeed remarkable observations that are supported, as the authors note, by basic science experiments that came to similar conclusions…”

http://www.amjmed.com/article/S0002-9343(13)00313-6/fulltext

The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults – The American Journal of Medicine

“There are limited data regarding the relationship between cannabinoids and metabolic processes. Epidemiologic studies have found lower prevalence rates of obesity and diabetes mellitus in marijuana users compared with people who have never used marijuana, suggesting a relationship between cannabinoids and peripheral metabolic processes. To date, no study has investigated the relationship between marijuana use and fasting insulin, glucose, and insulin resistance…

Conclusions

We found that marijuana use was associated with lower levels of fasting insulin and HOMA-IR, and smaller waist circumference…”

http://www.amjmed.com/article/S0002-9343(13)00200-3/fulltext

Novel study reports marijuana users have better blood sugar control

“Regular marijuana use is associated with favorable indices related to diabetic control, say investigators. They found that current marijuana users had significantly lower fasting insulin and were less likely to be insulin resistant, even after excluding patients with a diagnosis of diabetes mellitus. Their findings are reported in the current issue of The American Journal of Medicine

Editor-in-Chief Joseph S. Alpert, MD, Professor of Medicine at the University of Arizona College of Medicine, Tucson, comments, “These are indeed remarkable observations that are supported, as the authors note, by basic science experiments that came to similar conclusions.

“We desperately need a great deal more basic and clinical research into the short- and long-term effects of marijuana in a variety of clinical settings such as cancer, diabetes, and frailty of the elderly,” continues Alpert.” I would like to call on the NIH and the DEA to collaborate in developing policies to implement solid scientific investigations that would lead to information assisting physicians in the proper use and prescription of THC in its synthetic or herbal form.””

Read more: http://medicalxpress.com/news/2013-05-marijuana-users-blood-sugar.html 

Marijuana Users Have Better Blood Sugar Control – ScienceDaily

“May 15, 2013 — Regular marijuana use is associated with favorable indices related to diabetic control, say investigators. They found that current marijuana users had significantly lower fasting insulin and were less likely to be insulin resistant, even after excluding patients with a diagnosis of diabetes mellitus. Their findings are reported in the current issue of The American Journal of Medicine.

Marijuana (Cannabis sativa) has been used for centuries to relieve pain, improve mood, and increase appetite. Outlawed in the United States in 1937, its social use continues to increase and public opinion is swinging in favor of the medicinal use of marijuana. There are an estimated 17.4 million current users of marijuana in the United States. Approximately 4.6 million of these users smoke marijuana daily or almost daily. A synthetic form of its active ingredient, tetrahydrocannabinol, commonly known as THC, has already been approved to treat side-effects of chemotherapy, AIDS-induced anorexia, nausea, and other medical conditions. With the recent legalization of recreational marijuana in two states and the legalization of medical marijuana in 19 states and the District of Columbia, physicians will increasingly encounter marijuana use among their patient populations.

A multicenter research team analyzed data obtained during the National Health and Nutrition Survey (NHANES) between 2005 and 2010. They studied data from 4,657 patients who completed a drug use questionnaire. Of these, 579 were current marijuana users, 1,975 had used marijuana in the past but were not current users, and 2,103 had never inhaled or ingested marijuana. Fasting insulin and glucose were measured via blood samples following a nine hour fast, and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated to evaluate insulin resistance.

Participants who reported using marijuana in the past month had lower levels of fasting insulin and HOMA-IR and higher levels of high-density lipoprotein cholesterol (HDL-C). These associations were weaker among those who reported using marijuana at least once, but not in the past thirty days, suggesting that the impact of marijuana use on insulin and insulin resistance exists during periods of recent use. Current users had 16% lower fasting insulin levels than participants who reported never having used marijuana in their lifetimes.

Large waist circumference is linked to diabetes risk. In the current study there were also significant associations between marijuana use and smaller waist circumferences.

“Previous epidemiologic studies have found lower prevalence rates of obesity and diabetes mellitus in marijuana users compared to people who have never used marijuana, suggesting a relationship between cannabinoids and peripheral metabolic processes, but ours is the first study to investigate the relationship between marijuana use and fasting insulin, glucose, and insulin resistance,” says lead investigator Murray A. Mittleman, MD, DrPH, of the Cardiovascular Epidemiology Research Unit at the Beth Israel Deaconess Medical Center, Boston.

“It is possible that the inverse association in fasting insulin levels and insulin resistance seen among current marijuana users could be in part due to changes in usage patterns among those with a diagnosis of diabetes (i.e., those with diabetes may have been told to cease smoking). However, after we excluded those subjects with a diagnosis of diabetes mellitus, the associations between marijuana use and insulin levels, HOMA-IR, waist circumference, and HDL-C were similar and remained statistically significant,” states Elizabeth Penner, MD, MPH, an author of the study.

Although people who smoke marijuana have higher average caloric intake levels than non-users, marijuana use has been associated with lower body-mass index (BMI) in two previous surveys. “The mechanisms underlying this paradox have not been determined and the impact of regular marijuana use on insulin resistance and cardiometabolic risk factors remains unknown,” says coauthor Hannah Buettner.

The investigators acknowledge that data on marijuana use were self-reported and may be subject to underestimation or denial of illicit drug use. However, they point out, underestimation of drug use would likely yield results biased toward observing no association.

Editor-in-Chief Joseph S. Alpert, MD, Professor of Medicine at the University of Arizona College of Medicine, Tucson, comments, “These are indeed remarkable observations that are supported, as the authors note, by basic science experiments that came to similar conclusions.

“We desperately need a great deal more basic and clinical research into the short- and long-term effects of marijuana in a variety of clinical settings such as cancer, diabetes, and frailty of the elderly,” continues Alpert.” I would like to call on the NIH and the DEA to collaborate in developing policies to implement solid scientific investigations that would lead to information assisting physicians in the proper use and prescription of THC in its synthetic or herbal form.””