Tag Archives: Arthritis

UK Medical Cannabis Registry: An Updated Analysis of Inflammatory Arthritis

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A new analysis from the UK Medical Cannabis Registry reports sustained improvements in pain, sleep, and health-related quality of life among patients with inflammatory arthritis who were prescribed cannabis-based medicinal products.

The study followed 192 patients for up to 24 months. Improvements were reported across multiple pain measures at every follow-up point, including pain severity, pain interference, and overall pain scores. Sleep quality and general quality of life also improved compared with baseline.

Notably, many patients were prescribed THC-containing products, including dried cannabis flower and oils. The findings add long-term real-world evidence that prescribed cannabis medicines may help some people living with inflammatory arthritis.

“Aim: Cannabis-based medicinal products (CBMPs) are an emerging therapeutic option for pain in inflammatory arthritis, yet clinical evidence remains limited. This study aimed to evaluate changes in pain-specific and general health-related outcomes in patients with inflammatory arthritis treated with CBMPs and to characterize the safety profile by examining the incidence and nature of adverse events.

Methods: Patients treated with CBMPs for inflammatory arthritis-associated pain for ⩾24 months were identified from the UK Medical Cannabis Registry. Primary outcomes included changes in patient-reported measures: Brief Pain Inventory (BPI), Pain Visual Analogue Scale (Pain VAS), Short-Form McGill Pain Questionnaire 2 (SF-MPQ-2), EuroQol 5-dimension 5-level (EQ-5D-5L), Generalized Anxiety Disorder-7 (GAD-7), and Single-Item Sleep Quality Scale (SQS) at 1, 3, 6, 12, 18, and 24 months vs baseline. Adverse events were recorded and analysed. Statistical significance was set at P < .050.

Results: A total of 192 patients met inclusion criteria. The CBMP initiation was associated with improvements in BPI Interference, BPI Severity, Pain VAS, SF-MPQ-2, SQS, and EQ-5D-5L index values at all follow-up time points (P < .010) and in GAD-7 scores up to 3 months (P < .001). Twenty-seven patients (14.06%) reported 296 adverse events: 126 (42.57%) mild, 132 (44.59%) moderate, and 38 (12.84%) severe. No life-threatening events occurred.

Conclusion: The CBMP therapy was associated with reductions in pain and improvements in health-related quality of life among individuals with inflammatory arthritis. Although causality cannot be inferred from this observational design, these findings support the need for randomized controlled trials to determine the efficacy of CBMPs for inflammatory arthritis-related pain.”

https://pubmed.ncbi.nlm.nih.gov/42724108

“Overall, results of this study demonstrate reductions in pain severity and improvements in HRQoL for patients receiving CBMP treatment for chronic pain linked to inflammatory arthritis over a period of 24 months of follow-up. The CBMPs were generally well-tolerated, although the risk of AE and individual responses should be considered before commencing CBMP treatment.”

https://journals.sagepub.com/doi/10.1177/11795441261480709

News: Can marijuana treat the symptoms of Crohn’s Disease?

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“A new study, published in the journal Clinical Gastroenterology and Hepatology, suggests that cannabis could help relieve symptoms of Crohn’s Disease, a lifelong chronic illness that causes abdominal pain, cramping, diarrhea, nausea, vomiting, weight loss and lack of energy.”

News: Can marijuana treat the symptoms of Crohn

“That’s good news for sufferers, especially considering there is currently no cure.

Researchers studied 21 patients with Crohn’s Disease. Participants were randomly assigned to one of two groups: The first group was given cannabis cigarettes twice a day, the second group was given a  placebo containing cannabis flowers from which the THC had been removed.

“A short course (8 week) of THC-rich cannabis produced significant clinical, steroid-free benefits to 11 patients with active CD, compared to placebo, without side effects,” the study’s authors wrote.

The most promising part?

“Complete remission was achieved by 5/11 subjects in the cannabis group.”

Crohn’s patients aren’t the only ones who can benefit from marijuana’s medical properties, according to new research.

A recent study published in the American Journal of Medicine, suggests that marijuana can lower the risk of diabetes as well.

Marijuana users have lower fasting insulin levels, Murray Mittleman, associate professor of medicine at Harvard Medical School and the lead author of the study told Time Healthland. They are “less resistant to the insulin produced by their body to maintain a normal blood sugar level,”he says.

According to Health Canada, medical marijuana can also be used to manage symptoms like severe pain, cachexia, anorexia, weight loss, and severe nausea from cancer; arthritis pain; seizures from epilepsy; and pain and muscle spasms from spinal cord injuries and multiple sclerosis.”

More:http://www.besthealthmag.ca/blog/post/news-can-marijuana-cure-crohns-disease

Cannabis drug ‘fights pain without high’

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   “Scientists have developed a cannabis-based medicine which relieves chronic pain without any of the “high” normally associated with the drug.

They believe the discovery could pave the way for cannabis-based medication to become available by prescription within two years.

Much of the controversy surrounding the medicinal use of cannabis has centred on fears that it would be used solely for its mood-altering effects.

However, scientists at the University of Massachusetts in the United States say their discovery should help authorities to overcome these fears.

Dr Sumner Burstein and colleagues say early trials of the medication in animals and healthy patients have been promising.

The medication, called ajulemic acid or CT3, has been manufactured in laboratories.

It maximises the medicinal effects of tertrahydrocannabinol – the key ingredient of cannabis – without any of the mind-altering effects.

‘More effective’

In animal tests, this compound was found to be between 10 to 50 times more effective at reducing pain than tetrahydrocannabinol.

Those tests showed that ajulemic acid was very effective at preventing the joint damage associated with arthritis and relieving the muscle stiffness associated with multiple sclerosis.”

Read more: http://news.bbc.co.uk/2/hi/health/2207478.stm

Marijuana-Derived Compound Targets Pain, Inflammation

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   “Researchers are developing a marijuana-derived synthetic compound to relieve pain and inflammation without the mood-altering side effects associated with other marijuana based drugs.

  They say the compound could improve treatment of a variety of conditions, including chronic pain, arthritis and multiple sclerosis. Their findings were presented at the 224th national meeting of the American Chemical Society, the world’s largest scientific society.

   The compound, called ajulemic acid, has produced encouraging results in animal studies of pain and inflammation. It is undergoing tests in a group of people with chronic pain and could be available by prescription within two to three years, the researchers say.

 “We believe that [the compound] will replace aspirin and similar drugs in most applications primarily because of a lack of toxic side effects,” says Sumner Burstein, Ph.D., lead investigator in the study and a professor in the department of biochemistry and molecular pharmacology at the University of Massachusetts Medical School in Worcester. “The indications so far are that it’s safe and effective,” he added.”

Read more: http://www.sciencedaily.com/releases/2002/08/020822071026.htm

Suppression of fibroblast metalloproteinases by ajulemic acid, a nonpsychoactive cannabinoid acid.

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Abstract

   “Production of matrix metalloproteinases (MMP) in joint tissue of patients with inflammatory arthritis facilitates cartilage degradation and bone erosion, and leads to joint deformities and crippling. Thus, MMPs are important targets for agents designed to treat inflammatory arthritis. Oral administration of ajulemic acid (AjA), a synthetic, nonpsychoactive cannabinoid acid, prevents joint tissue injury in rats with adjuvant arthritis. AjA binds to and activates PPARgamma directly. Therefore, we investigated the influence of AjA on MMP production in human fibroblast-like synovial cells (FLS), and examined the role of PPARgamma in the mechanism of action of AjA. FLS, treated or not with a PPARgamma antagonist, were treated with AjA then stimulated with TNFalpha or IL-1alpha. Release of MMPs-1, 3, and 9 was measured by ELISA. The influence of AjA on MMP-3 release from stimulated PPARgamma positive (PPAR+/-) and PPARgamma null (PPAR-/-) mouse embryonic fibroblasts (MEF) was also examined. Addition of AjA to FLS suppressed production of MMPs whether or not PPARgamma activation was blocked. Secretion of MMP-3 was also suppressed by AjA in both TNFalpha- and IL-1alpha-stimulated PPARgamma+/- and PPARgamma-/- MEF. Suppression of MMP secretion from FLS by AjA appears to be PPARgamma independent. Prevention by AjA of joint tissue injury and crippling in the rat adjuvant arthritis model may be explained in large part by inhibition of MMPs. These results suggest that AjA may be useful for treatment of patients with rheumatoid arthritis and osteoarthritis.”

http://www.ncbi.nlm.nih.gov/pubmed/16927387

Marijuana, inflammation, and CT-3 (DMH-11C): cannabis leads to new class of antiinflammatory drugs.

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Abstract:

“CT-3, a synthetic derivative of a metabolite of marijuana, is being tested by arthritis researchers as a possible new anti-inflammatory drug. Early studies show that CT-3 may be effective without the gastric side effects of steroids and psychoactive effects of marijuana. The processes of inflammation may be important in the pathogenesis of HIV disease. Obtaining the medical benefits without the psychoactive effects of marijuana is also important, as the high associated with cannabis use can be debilitating. The drug is currently in early pre-clinical animal testing.”

http://www.ncbi.nlm.nih.gov/pubmed/11365002

THC From Cannabis Destroys Cancer Cells

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“The study results strongly suggest that if taken regularly, cannabis oil may be able to induce remission in leukemia patients without the horrendous side effects typically associated with standard radio-chemical treatment options. Although this is only one such study, other similar studies have shown equally impressive results.

 Many of the active ingredients found in cannabis-derived drugs show exceptional promise in treating some of the greatest hurdles facing modern medical science. In addition to their aforementioned capacity for safely treating certain forms of deadly cancer, they also show great promise in alleviating autoimmune conditions such as rheumatoid arthritis, multiple sclerosis, and even inflammatory bowel disease. A growing number of experts also note their possible viability treating a range of neurological disorders including Alzheimer’s and Lou Gehrig’s disease.”

http://www.globalhealingcenter.com/natural-health/thc-from-cannabis-destroys-cancer-cells/

Juicing cannabis miraculously saves lives after physicians declare the battle lost

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“(NaturalNews) At 16, Kristen Peskuski was suffering from joint inflammation and an array of autoimmune conditions which made her organs and other tissues swell, including interstitial cystitis and lupus. She was prescribed over 40 different anti-inflammatory, antibiotic and painkilling medications to combat the symptoms. Still struggling to bring the symptoms under control, Kristen developed steroid toxicity. She was told that the most she could hope for was reduced discomfort, and with luck, she might make it to her 30th birthday. Seeking alternative treatments, she began juicing raw cannabis leaves every day, and within two months, Kristen’s back pain had been eliminated, and she had stopped using any other painkillers.”

Learn more: http://www.naturalnews.com/035400_juicing_cannabis_remedies.html#ixzz29OcuQ7gQ

Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees

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“Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic (OA) knees… application of the CB(1) agonist significantly reduced the firing rate of afferent nerve fibers… These findings indicate that activation of peripheral CB(1) receptors reduces the mechanosensitivity of afferent nerve fibers in control and OA knee joints. As such, peripheral CB(1) receptors may be important targets in controlling OA pain.”

http://www.ncbi.nlm.nih.gov/pubmed/18163511

Rheumatoid arthritis, cannabis based medicine eases pain and suppresses disease

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“The first study to use a cannabis-based medicine (CBM) for treating rheumatoid arthritis has found that it has a significant effect on easing pain and on suppressing the disease”

http://www.medicalnewstoday.com/releases/33376.php