Marijuana Relieves Chronic Pain, Research Shows – WebMD

“Three puffs a day of cannabis, better known as marijuana, helps people with chronic nerve pain due to injury or surgery feel less pain and sleep better, a Canadian team has found.

”It’s been known anecdotally,” says researcher Mark Ware, MD, assistant professor of anesthesia and family medicine at McGill University in Montreal. “About 10% to 15% of patients attending a chronic pain clinic use cannabis as part of their pain [control] strategy,” he tells WebMD.

But Ware’s study is more scientific — a clinical trial in which his team compared placebo with three different doses of cannabis. The research is published in CMAJ, the Canadian Medical Association Journal.

The new study ”adds to the trickle of evidence that cannabis may help some of the patients who are struggling [with pain] at present,” Henry McQuay, DM, an emeritus fellow at Balliol College, Oxford University, England, writes in a commentary accompanying the study…” More: http://www.webmd.com/pain-management/news/20100830/marijuana-relieves-chronic-pain-research-show

“Smoked cannabis for chronic neuropathic pain: a randomized controlled trial… A single inhalation of 25 mg of 9.4% tetrahydrocannabinol herbal cannabis three times daily for five days reduced the intensity ofpain, improved sleep and was well tolerated.”  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950205/

For many patients, cannabis may offer the best medicinal pain relief yet discovered

by: Raw Michelle

“(NaturalNews) By the beginning of the 1980s, after a four decade long lockdown, a re-interest in cannabis arose in the scientific community. In 1982, the American Institute of Medicinepublished an intriguing report entitled “Marijuana and Health”. The report was a collection of tentative exploratory research and case studies of the use of cannabis as a medicine.

The reappearance of a powerful plant in human pharmacopeia

The studies provided a glimpse of something that intrigued health care researchers. While the plant’s effects were entirely congruent with the goal of healing, the methodology used by the plant’s chemicals was very different from those employed by typical pharmaceuticals. To developers, cannabis suddenly represented a precedent for a whole new type of medicine. With over 88 pharmacologically active substances, cannabis introduced hundreds of new compounds to the medical world. The institute’s report concluded that further research into cannabis’ potential would be of great value to the field.

However, further research was very limited, stifled by cannabis’ legal status and social stigma. The legal status forces researchers to expend an overwhelming amount of time and effort to get permission to conduct the studies. The social stigma causes institutes to be less likely to receive funding for the projects, and that researchers are sacrificing their reputation in the professional world. That also means most of the studies conducted are federally funded. Unfortunately, in addition, successful researchers will still have to face a further publication bias, as journals also risk their reputations and status when publishing cannabis related research. It is ironic that even within a scientific community, researchers are punished for being unbiased. As a result, outlets that focus solely on cannabis related research have arisen. Internet publications have opened a wide market for research that would have previously been buried.

Where opiates don’t quite cut it

Of the studies that have been conducted, most have focused on marijuana as a treatment for neuropathic pain, one of the earliest treatments for which physicians saw potential. Neuropathic pain results from nerve damage in which the cells experience difficulty communicating. This can happen from traumas like surgery, where nerve connections are severed, but continue trying to communicate news of the damage to the next cell over. Similarly, when new nerve cells are formed but not yet hooked into the neural highway, they sputter and spark, trying to achieve connection. The sensation can be very painful. Neuropathic pain is very common symptom of cancer. Tumour growth can crush nerve trunks as it bullies its way to more territory.

Sometimes just talking about it helps

Early studies demonstrate that cannabis is hugely effective in treating neuropathic pain. The cannabinoids allow nerve cells to reverse the communication path. Cells sending trauma notifications to the main trunk would normally continue doing so until the stimuli was resolved. From a practical standpoint, it is difficult to eliminate pain the moment it is recognised, but from a human level, once the person is cognizant of the problem, there is no benefit to remaining in pain. Cannabis simply tells the alarmed cell that authorities have been notified and that the problem will be resolved shortly. It doesn’t, as is popularly believed, relieve pain by making cells “stoned” or unfocused so as to disrupt communication.

The few studies have been conducted have returned agreeing with the American Medical Institute’s findings and recommendations. After only preliminary examination, cannabis presents itself as a powerful tool. More in-depth research is likely to further displace today’s most relied-upon pharmaceuticals.”

 
 
 

Cannabis stops the pain

“Ann Vernon would like to understand one thing about the lawmakers who oppose the medical use of cannabis.

“I think you would have to be pretty heartless if you’re faced with these absolutely desperate people . . . and they say this [cannabis] helps and you turn them down? I don’t know.”

It is a question Ms Vernon, who sufferers from chronic pain and post-traumatic stress disorder, asks herself often. The most recent occasion was last week when she was standing before a judge on charges of cultivating cannabis.

Ms Vernon, 40, had plants in her home because she uses cannabis to ease her chronic pain. When the judge heard her medical evidence, backed by her doctor, he discharged her without conviction.

“He listened to me talk about what it was like to live with constant pain.”

The mother of three has now vowed to devote her time to fighting for changes in the law to allow the use of cannabis for medical purposes.

It was a doctor who first suggested cannabis to Ms Vernon.

Years and years of chronic pain – she was thrown from a horse as a teen and later suffered complications from surgery – left the once-active woman bedridden and in constant agony.

Sitting and standing were so agonising she would cart a mattress from room to room just so she could lie down.

Conventional painkillers failed and eventually cannabis was recommended.

“At first I was like ‘Oh what!’ I’d smoked cannabis as a teenager . . . now and then,” she says. “But then you get that desperate you will try anything.”

The drug – ingested with a vapouriser she imported from Australia – worked.

“With cannabis I have quality of life. I’ve come so far now that clearly I am not bedridden.”

Ms Vernon says that, while cannabis comes with a high, medical users get used to that very quickly. “I don’t find the high from the cannabis anywhere near as debilitating as the high I was getting from normal painkillers.”

Cannabis also helps with sleep and with appetite. “I also had a huge amount of nausea and that just wipes it.”

But she says it is hard not to feel like a criminal: “I have never even had a traffic infringement notice, not a parking ticket, nothing. So, yes, breaking the law is awful. To be made to feel like a criminal for something a doctor recommended to me and has helped me is awful.”

Being allowed to grow cannabis for medicinal use would mean less harm to the community, she says.

“It is also very hard, and very expensive, to get decent-quality cannabis. The supply is inconsistent, you don’t know what you are getting.”

Medical-cannabis patients are rendered vulnerable, she says.

“Many of them are much worse off physically than me and can’t come forward to speak.

“Some of the things I have seen, some of the effects I’ve seen of people when they consume cannabis. I’ve seen people get some movement back in limb they’ve had no movement in for eight years.

“I can’t imagine how cold people have to be to stop them from using the one thing that helps them.””

http://www.stuff.co.nz/dominion-post/news/national/7992118/Cannabis-stops-the-pain

From cannabis to the endocannabinoid system: refocussing attention on potential clinical benefits.

Image result for West Indian Med J

“Cannabis sativa is one of the oldest herbal remedies known to man. Over the past four thousand years, it has been used for the treatment of numerous diseases but due to its psychoactive properties, its current medicinal usage is highly restricted. In this review, we seek to highlight advances made over the last forty years in the understanding of the mechanisms responsible for the effects of cannabis on the human body and how these can potentially be utilized in clinical practice. During this time, the primary active ingredients in cannabis have been isolated, specific cannabinoid receptors have been discovered and at least five endogenous cannabinoid neurotransmitters (endocannabinoids) have been identified. Together, these form the framework of a complex endocannabinoid signalling system that has widespread distribution in the body and plays a role in regulating numerous physiological processes within the body. Cannabinoid ligands are therefore thought to display considerable therapeutic potential and the drive to develop compounds that can be targeted to specific neuronal systems at low enough doses so as to eliminate cognitive side effects remains the ‘holy grail’ of endocannabinoid research.”

http://www.ncbi.nlm.nih.gov/pubmed/23155985

Marijuana May Fight Lung Tumors – FoxNews

   “…the active ingredient in marijuana may help combat lung cancer, new research suggests.

In lab and mouse studies, the compound, known as THC, cut lung tumor growth in half and helped prevent the cancer from spreading, says Anju Preet, PhD, a Harvard University researcher in Boston who tested the chemical. 

While a lot more work needs to be done, “the results suggest THC has therapeutic potential,” she tells WebMD. 

Moreover, other early research suggests the cannabis compound could help fight brain, prostate, and skin cancers as well, Preet says.”

Read more: http://www.foxnews.com/story/0,2933,266715,00.html

Read more: http://www.foxnews.com/story/0,2933,266715,00.html#ixzz2C1POR7Ap

Media Ignored Expert’s Shocking Findings That Marijuana Helps Prevent Lung Cancer: Now It’s Med-School Material

  “You’d think it would have been very big news in the spring of 2005 when Donald Tashkin, a professor of pulmonology at UCLA’s David Geffin School of Medicine, revealed at a conference that components of marijuana smoke, although they damage cells in respiratory tissue, somehow prevent them from becoming malignant. But headlines announcing “Pot Doesn’t Cause Cancer” did not ensue. ”

“As to the highly promising implication of his own study — that something in marijuana stops damaged cells from becoming malignant — Tashkin noted that an anti-proliferative effect of THC has been observed in cell-culture systems and animal models of brain, breast, prostate, and lung cancer. THC has been shown to promote known apoptosis (damaged cells die instead of reproducing) and to counter angiogenesis (the process by which blood vessels are formed — a requirement of tumor growth). Other antioxidants in cannabis may also be involved in countering malignancy, Tashkin said.”

Read more: http://www.alternet.org/drugs/media-ignored-experts-shocking-findings-marijuana-helps-prevent-lung-cancer-now-its-med-school

Pot Smoking Not Linked to Lung Cancer – WebMD

“People who smoke marijuana do not appear to be at increased risk for developing lung cancer, new research suggests.

While a clear increase in cancer risk was seen among cigarette smokers in the study, no such association was seen for regular cannabis users.

Even very heavy, long-term marijuana users who had smoked more than 22,000 joints over a lifetime seemed to have no greater risk than infrequent marijuana users or nonusers.

The findings surprised the study’s researchers, who expected to see an increase in cancer among people who smoked marijuana regularly in their youth.”

Read more: http://www.webmd.com/lung-cancer/news/20060523/pot-smoking-not-linked-to-lung-cancer

Marijuana Smokers Breathe Easy Says The University of Alabama

   “As of January 10, 2012, a new study has been published in the Journal of the American Medical Association exonerating marijuana from the bad reputation of being as harmful to your lungs when smoked as tobacco cigarettes. Researchers at the University of California San Francisco and the University of Alabama at Birmingham completed a twenty-year study between 1986 and 2006 on over 5,000 adults over the age of 21 in four American cities. Study co-author Dr. Stefan Kertesz is a professor of preventive medicine at the University of Alabama at Birmingham. He explained that the studies measured the pulmonary obstruction in individuals with up to seven joint-years of lifetime exposure (one joint per day for seven years or one joint per week for 49 years). “What this study clarifies,” Kertesz explains in a released video, “is that the relationship to marijuana and lung function changes depending on how much a person has taken in over the course of a lifetime.”

“…findings suggest that occasional use of marijuana may not be linked with unfavorable consequences on pulmonary function.  Marijuana is designated by the U.S. government as a Schedule I drug, which declares it has no medicinal purposes.  Previous studies have shown that the drug can be used to treat multiple sclerosis, glaucoma, nausea, and pain.  It has been known to have beneficial effects on pain control, mood, appetite, and managing of other chronic symptoms.  Despite these facts, marijuana continues to be depicted as more damaging to us than it’s legal counterpart tobacco. Marijuana activists, medical patients, and recreational users alike will rejoice knowing the evidence shows otherwise.”

Read more: http://nugs.com/article/marijuana-smokers-breathe-easy-says-the-university-of-alabama.html

Study: Smoking Marijuana Not Linked with Lung Damage – TIME

“Marijuana does not impair lung function—at least not in the doses inhaled by the majority of users, according to the largest and longest study ever to consider the issue, which was published today in the Journal of the American Medical Association.

Researchers working on a long-term study of risk factors for cardiovascular disease (the Coronary Artery Risk Development in Young Adults or CARDIA study) tested the lung function of 5115 young adults over the course of 20 years, starting in 1985 when they were aged 18 to 30.

The study was “well conducted” and is “essentially confirmatory of the findings from several previous studies that have examined the association between marijuana smoking and lung function,” says Dr. Donald Tashkin, professor of medicine at UCLA and a leading scientist in the area. He was not associated with the new research.

“The major strengths of this study are that it included a far larger number of subjects followed for longer than any of these previous studies,” he adds.”

Read more: http://healthland.time.com/2012/01/10/study-smoking-marijuana-not-linked-with-lung-damage/

Casual Marijuana Smoking Not Harmful to Lungs

“It wouldn’t have mattered if Bill Clinton inhaled, as far as his lungs are concerned. Smoking up to a joint per day doesn’t seem to decrease lung function, according to a study published in Jan. 11 edition of Journal of the American Medical Association.

In fact, occasional marijuana use was associated with slight increases in lung airflow rates and increases in lung volume, the study found.

Far from a license to light up, the study eases the worry among some health professionals that daily use of marijuana for medical reasons could have negative, long-term implications on pulmonary health.”

Read more: http://www.scientificamerican.com/article.cfm?id=casual-marijuana-smoking&fb_action_ids=462987810404532&fb_action_types=og.likes&fb_source=aggregation&fb_aggregation_id=288381481237582