Category Archives: Endocannabinoid System

Alzheimer’s disease; taking the edge off with cannabinoids?

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“Thus, cannabinoids offer a multi-faceted approach for the treatment of Alzheimer’s disease by providing neuroprotection and reducing neuroinflammation, whilst simultaneously supporting the brain’s intrinsic repair mechanisms by augmenting neurotrophin expression and enhancing neurogenesis. The evidence supporting a potential role for the cannabinoid system as a therapeutic target for the treatment of Alzheimer’s disease will be reviewed herewith.”

http://www.medicalmarijuanainc.com/index.php/alzheimer-s-disease

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190031/

Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease

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“CBD is able to modulate microglial cell function in vitro and induce beneficial effects in an in vivo model of AD. Given that CBD lacks psychoactivity, it may represent a novel therapeutic approach for this neurological disease.”

http://www.medicalmarijuanainc.com/index.php/alzheimer-s-disease

Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action

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“These studies have suggested a wide range of possible therapeutic effects of cannabidiol on several conditions, including Parkinson’s disease, Alzheimer’s disease, cerebral ischemia, diabetes, rheumatoid arthritis, other inflammatory diseases, nausea and cancer.”

http://www.medicalmarijuanainc.com/index.php/alzheimer-s-disease

Cannabis Science Announces Critical Cancer Patient Dr. Lynnice Wedewer, Ph.D., Cured Seven Times By Medical Cannabis

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“Cannabis Science Inc. a pioneering US biotech company developing pharmaceutical cannabis products, is pleased to announce that it has been contacted by Lynnice Wedewer, Ph.D. who is a 34 year multiple cancer patient survivor who has been cured of 7 of her 8 cancers in a major part because of medical cannabis.

Dr. Wedewer wishes to share her story through Cannabis Science and help our case and education towards general acceptance of medical cannabis as a natural and viable treatment for cancer.”

 More: http://www.reuters.com/article/2011/06/29/idUS207485+29-Jun-2011+BW20110629

Cannabis Science Provides Physician’s Documentation That Confirms Successful Treatment of Skin Cancer

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April 6, 2011 “We are pleased to announce that we have physician’s documentation that confirms the successful treatment of basal cell carcinoma that resulted from the application of a topical cannabis extract.”

http://www.drugs.com/clinical_trials/cannabis-science-provides-physician-s-documentation-confirms-successful-skin-cancer-11517.html

http://www.cannabisscience.com/news-a-media/press-releases/224-cbis-provides-physicians-documentation.html

 

The endocannabinoid system in amyotrophic lateral sclerosis

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“The endocannabinoid system in amyotrophic lateral sclerosis… Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative condition… there is significant evidence that several neurotoxic mechanisms including excitotoxicity, inflammation and oxidative stress, all contribute to disease pathogenesis… there is increasing evidence that cannabinoids and manipulation of the endocannabinoid system may have therapeutic value in ALS, in addition to other neurodegenerative conditions. Cannabinoids exert anti-glutamatergic and anti-inflammatory actions through activation of the CB(1) and CB(2) receptors… cannabinoid agents also exert anti-oxidant actions… the ability of cannabinoids to target multiple neurotoxic pathways in different cell populations increase their therapeutic potential in the treatment of ALS.”

http://www.ncbi.nlm.nih.gov/pubmed/18781981

The Cannabinergic System as a Target for Anti-inflammatory Therapies

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“Cell-based experiments or in vivo animal testing suggest that regulation of the endocannabinoid circuitry can impact almost every major function associated with the immune system. These studies were assisted by the development of numerous novel molecules that exert their biological effects through the endocannabinoid system. Several of these compounds were tested for their effects on immune function, and the results suggest therapeutic opportunities for a variety of inflammatory diseases such as multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, allergic asthma, and autoimmune diabetes through modulation of the endocannabinoid system.”

http://www.ingentaconnect.com/content/ben/ctmc/2006/00000006/00000013/art00008

Cannabinoid type 1 receptors located on single-minded 1-expressing neurons control emotional behaviors.

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“Cannabinoid type 1 receptors located on single-minded 1-expressing neurons control emotional behaviors… This study suggests that CB1 receptors located on Sim1-expressing neurons exert a tonic control on locomotor reactivity, unconditioned anxiety, and cued-fear expression under basal conditions as well as after acute or repeated stress.”

http://www.ncbi.nlm.nih.gov/pubmed/21920410

CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types

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“Marijuana cannabinoid receptors (CBR), CB1 and CB2… CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types… results suggest that CBR expression is relatively constant across the human population.”

http://www.ncbi.nlm.nih.gov/pubmed/11727770

Expression of cannabinoid receptors and their gene transcripts in human blood cells.

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Food for thought: ” Normal human volunteers who do not use marijuana have genes that encode for the marijuana (cannabinoid) receptor proteins… We therefore concluded that the existence of… Expression of cannabinoid receptors and their gene transcripts in human blood cells.”— Human blood contains cannabinoid receptors.

http://www.ncbi.nlm.nih.gov/pubmed/10621950