Category Archives: News Stories

Synthetic Agents Related To Active Ingredient In Marijuana Weaken HIV Infection – MedicalNewsToday

Posted on by

“HIV, the virus that causes AIDS, is notorious for hiding within certain types of cells, where it reproduces at a slowed rate and eventually gives rise to chronic inflammation, despite drug therapy. But researchers at Temple University School of Medicine’s Department of Pathology and Laboratory Medicine and Center for Substance Abuse Research (CSAR) recently discovered that synthetic anti-inflammatory substances distantly related to the active ingredient of marijuana may be able to take the punch out of HIV while inside one of its major hideouts – immune cells known as macrophages.

The breakthrough comes at a crucial time in the HIV/AIDS pandemic…

To better understand the connection between inflammation and neurocognitive conditions linked to long-term exposure to HIV, Ramirez and colleagues looked specifically at the CB2 receptor, a protein located on the surface of macrophages. CB2 is a binding site for substances called cannabinoids, the primary active compounds of cannabis (marijuana), and it may play a role in blocking inflammation in the CNS. Unlike its counterpart, the CB1 receptor, which is found primarily on neurons in the brain, CB2 does not mediate the psychoactive effects for which cannabis is popularly known.

Ramirez explained that there has been much pharmacological interest in developing agents that selectively target CB2. Ideally, these compounds would help limit chronic inflammatory responses and would not bind to CB1.

The most promising compounds are those derived from THC (tetrahydrocannabinol), the main active substance in cannabis.”

More: http://www.medicalnewstoday.com/releases/259980.php

Synthetic derivatives of THC may weaken HIV-1 infection to enhance antiviral therapies – MedicalXpress

Posted on by

“A new use for compounds related in composition to the active ingredient in marijuana may be on the horizon: a new research report published in the Journal of Leukocyte Biology shows that compounds that stimulate the cannabinoid type 2 (CB2) receptor in white blood cells, specifically macrophages, appear to weaken HIV-1 infection. The CB2 receptor is the molecular link through which the pharmaceutical properties of cannabis are manifested. Diminishing HIV-1 infection in this manner might make current anti-viral therapies more effective and provide some protection against certain HIV-1 complications.

“The synthetic compounds we used in our study may show promise in helping the body fight HIV-1 infection,'” said Yuri Persidsky, M.D., Ph.D., a researcher involved in the work from the Department of Pathology and Laboratory Medicine at Temple University School of Medicine in Philadelphia, PA. “As compounds like these are improved further and made widely available, we will continue to explore their potential to fight other viral diseases that are notoriously difficult to treat.”

To make this discovery, scientists used a cell culture model to infect human macrophages with HIV-1 and added synthetic compounds similar to the active ingredient in marijuana to activate the CB2 receptor. At different times during the infection, samples from the culture were taken to see if the replication of the HIV virus was decreased. The researchers observed diminished HIV growth and a possible protective effect from some HIV-1 complications.

“HIV/AIDS has posed one of the most significant health challenges in modern medicine,” said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. “Recent high profile vaccine failures mean that all options need to be on the table to prevent or treat this devastating infection. Research on the role of cannabinoid type 2 receptors and viral infection may one day allow targeting these receptors to be part of combination therapies that use exploit multiple weaknesses of the virus simultaneously.””

http://medicalxpress.com/news/2013-04-synthetic-derivatives-thc-weaken-hiv-.html

Scientists weaken HIV infection in immune cells using synthetic agents – MedicalXpress

Posted on by

“HIV, the virus that causes AIDS, is notorious for hiding within certain types of cells, where it reproduces at a slowed rate and eventually gives rise to chronic inflammation, despite drug therapy. But researchers at Temple University School of Medicine’s Department of Pathology and Laboratory Medicine and Center for Substance Abuse Research (CSAR) recently discovered that synthetic anti-inflammatory substances distantly related to the active ingredient of marijuana may be able to take the punch out of HIV while inside one of its major hideouts – immune cells known as macrophages.

The results suggest that selective CB2 agonists could potentially be used in tandem with existing antiretroviral drugs, opening the door to the generation of new drug therapies for HIV/AIDS. The data also support the idea that the human immune system could be leveraged to fight HIV infection.

“Our study suggests that the body’s own natural defenses can be made more powerful to fight some of the worst symptoms of HIV,” Persidsky explained. He also noted that stimulating CB2 receptors in white blood cells could produce similar benefits against other viral infections.

 The most promising compounds are those derived from THC (tetrahydrocannabinol), the main active substance in cannabis.”

More: http://medicalxpress.com/news/2013-05-scientists-weaken-hiv-infection-immune.html

Banning Psychedelic Drugs Hurts Research, Scientists Say

Posted on by
“Restricting the use of psychoactive drugs in research represents the most serious case of scientific censorship since the Catholic Church banned the works of Copernicus and Galileo, some scientists say.” 

psychedelic smoke

 
  

“In a paper published online today (June 12) in the journal Nature Reviews Neuroscience, a group of researchers argues that drug laws enacted in the United States and the United Kingdom during the 1960s and 1970s have hindered vital research into the drugs’ functions and therapeutic uses.”

More: http://www.livescience.com/37365-drugs-bans-restrict-research.html

Drug laws ‘hit medical research’

Posted on by

“International drug laws have set back key areas of scientific research including potential medical treatments, a controversial former government drugs adviser has warned.

In the journal Nature Reviews Neuroscience, Professor David Nutt, of Imperial College London, said UN conventions on drugs act as some of the most scandalous examples of scientific censorship in modern times.

Along with another former government adviser, Leslie King, and Professor David Nichols, of the University of North Carolina, Prof Nutt argues that psychoactive drugs used in research should be exempted from severe restrictions.

Prof Nutt resigned as the chairman of the Advisory Council on Misuse of Drugs (ACMD) in November 2009 over the decision to reclassify cannabis from a Class C to a Class B drug. The possession of cannabis, Ecstasy and psychedelics is regulated under national laws and international conventions dating back to the 1960s.

Prof Nutt said: “The decision to outlaw these drugs was based on their perceived dangers, but in many cases the harms have been overstated and are actually less than many legal drugs such as alcohol.”

More: http://uk.news.yahoo.com/drug-laws-hit-medical-research-040455765.html#NAVDFvc

‘Absurd’ drug laws ‘hinder research’ – Prof David Nutt – BBC

Posted on by
“‘Absurd’ laws dealing with magic mushrooms, ecstasy and cannabis are hindering medical research, according to a former government drugs adviser.”
 
Magic mushrooms 
 
“Prof David Nutt says he has funding to research the use of the chemical psilocybin – found in fungi known as “magic mushrooms” to treat depression.But he says “insane” regulations mean he cannot get hold of the drug.”

More: http://www.bbc.co.uk/news/health-22042994

Restrictive drug laws censor science, researchers say – Reuters

Posted on by

“The outlawing of drugs such as cannabis, magic mushrooms and other psychoactive substances amounts to scientific censorship and is hampering research into potentially important medicinal uses, leading scientists argued on Wednesday.”

The British government's former chief drugs adviser, David Nutt, reacts as he speaks during a news conference announcing the formation of the Independent Scientific Committee on Drugs, in London January 15, 2010. REUTERS/Suzanne Plunkett

 

“Laws and international conventions dating back to the 1960s have set back research in key areas such as consciousness by decades, they argued in the journal Nature Reviews Neuroscience.

“The decision to outlaw these drugs was based on their perceived dangers, but in many cases the harms have been overstated,” said David Nutt, a professor of neuropsychopharmacology at Imperial College London.

In a statement accompanying the Nature Reviews paper, he said the laws amounted “to the worst case of scientific censorship since the Catholic Church banned the works of Copernicus and Galileo”.

“The laws have never been updated despite scientific advances and growing evidence that many of these drugs are relatively safe. And there appears to be no way for the international community to make such changes,” he said.

“This hindering of research and therapy is motivated by politics, not science.””

More: http://www.reuters.com/article/2013/06/12/us-drugs-science-idUKBRE95B03320130612

Outlawing of Psychoactive Drugs ‘Scientific Censorship’ Says Former Drug Advisor

Posted on by

“Criminalization of marijuana, psychedelic mushrooms and other psychoactive drugs in the United Kingdom amounts to an act of scientific censorship that inhibits further research from being done, according to a leading researcher on the effects of drugs on the human brain.”

marijuana  

“Outlawing of psychoactive drugs amounts to “the worst case of scientific censorship since the Catholic Church banned the works of Copernicus and Galileo,” said David Nutt, a professor of neuropsychopharmacology at Imperial College London, in a statement accompanying a paper published in the journal Nature Reviews Neuroscience.”

More: http://www.natureworldnews.com/articles/2407/20130612/outlawing-psychoactive-drugs-scientific-censorship-former-drug-advisor.htm

Outlawing drugs like marijuana censors science, researchers say – FOX

Posted on by

“The outlawing of drugs such as cannabis, magic mushrooms and other psychoactive substances amounts to scientific censorship and is hampering research into potentially important medicinal uses, leading scientists argued on Wednesday.”

New-Pot.jpg
 

“Laws and international conventions dating back to the 1960s have set back research in key areas such as consciousness by decades, they argued in the journal Nature Reviews Neuroscience.

“The decision to outlaw these drugs was based on their perceived dangers, but in many cases the harms have been overstated,” said David Nutt, a professor of neuropsychopharmacology at Imperial College London.

In a statement accompanying the Nature Reviews paper, he said the laws amounted “to the worst case of scientific censorship since the Catholic Church banned the works of Copernicus and Galileo”.

“The laws have never been updated despite scientific advances and growing evidence that many of these drugs are relatively safe. And there appears to be no way for the international community to make such changes,” he said.

“This hindering of research and therapy is motivated by politics, not science.”

Nutt and Leslie King, both former British government drugs advisers, and co-author David Nichols of the University of North Carolina, called for the use of psychoactive drugs in research to be exempted from severe restrictions.

“If we adopted a more rational approach to drug regulation, it would empower researchers to make advances in the study of consciousness and brain mechanisms of psychosis, and could lead to major treatment innovations in areas such as depression and PTSD,” Nutt said.

Nutt was sacked as a government adviser in 2009 after publicly criticizing the government for ignoring scientific advice on cannabis and ecstasy. He has conducted a small human trial using psilocybin, the psychedelic ingredient in magic mushrooms.

His study, using volunteers, suggested the drug had the potential to alleviate severe forms of depression in people who did not respond to other treatments.

But in April, Nutt said his plans to conduct the first full clinical trial to explore psilocybin as a treatment had stalled because of stringent rules on the use of illegal drugs in research.

The scientists said their call for reform had been endorsed by the British Neuroscience Association and the British Association for Psychopharmacology.”

http://www.foxnews.com/health/2013/06/12/outlawing-drugs-like-marijuana-censors-science-researchers-say/

‘The worst case of scientific censorship since the Catholic Church banned the works of Galileo’: Scientists call for drugs to be legalised to allow proper study of their properties

Posted on by

 “The outlawing of drugs such as cannabis, MDMA and LSD amounts to the “the worst case of scientific censorship since the Catholic Church banned the works of Copernicus and Galileo”, the former Government drugs advisor Professor David Nutt has claimed.”

Professor Nutt, who was dismissed from the Home Office’s advisory council on drugs in 2009 after clashing with ministers, said that UN conventions on drugs in the 1960s and 1970s have delayed the development of “innovative treatments” for PTSD and depression by 30 years and also set back research into areas of neuroscience such as consciousness.

In a paper published today with two other scientists in the journal Nature Reviews Neuroscience, he said that drugs policy is being driven by “politics, not science”.

Professor Nutt left the Home Officer in 2009 after suggesting that taking MDMA ecstasy was no more dangerous than horse-riding and that alcohol and tobacco were more dangerous than many illegal drugs.

The possession of psychoactive drugs such cannabis, MDMA (ecstasy) and LSD for scientific purposes is stringently regulated in the UK and most other countries, in accordance with UN conventions that were agreed in response to the emergence of drug culture in the 1960s and 1970s.

Applying for a Government licence can be costly and time-consuming and many scientists are put off by a culture of “repression” surrounding drug science, Professor Nutt said.

“The laws scare off funders and most scientists are scared because they think if they break the law, they might get arrested,” he told The Independent. “I’m sure at some point someone’s going to arrest me. There is a sense of repression to the point that most people won’t do it.”

The paper, which is published to coincide with a conference on scientific research with psychedelics at Imperial College London, points to evidence that cannabis, MDMA and psychedelics such as LSD and psilocybin (the compound found in magic mushrooms) have unexplored medicinal benefits and argues that laws should be updated.

Small clinical studies of MDMA, which was originally used in the USA in the 1970s to improve communication in psychotherapy sessions, suggested that it could play a highly beneficial role in the treatment of PTSD patients. The paper’s authors said the drug could also help with “end of life anxiety” and couples therapy”.

Medical use of marijuana is already legal in 17 US states, and the drug has been shown to have benefits such as anxiety reduction and pain relief. However, Professor Nutt said that UK restrictions had blocked development of therapeutic applications for any of cannabis’ 16 active ingredients.

LSD, meanwhile, was widely researched in the 1950s and 1960s, with more than 1,000 papers investigating outcomes for more than 40,000 patients, with evidence suggesting that the drug might be an effective treatment for alcoholism, before bans on the drug around the world ended further research.”

-Charlie Cooper

http://www.independent.co.uk/news/science/the-worst-case-of-scientific-censorship-since-the-catholic-church-banned-the-works-of-galileo-scientists-call-for-drugs-to-be-legalised-to-allow-proper-study-of-their-properties-8654514.html