Category Archives: Breast Cancer

Cannabis Compound May Stop Metastatic Breast Cancer

Posted on by

“A non-toxic, non-psychoactive compound in marijuana may block the progress of metastatic breast cancer, according to a new study by researchers in California.

“This is a new way to treat a patient that is not toxic like chemotherapy or radiotherapy. It is a new approach for metastatic cancer,” said lead researcher Sean D. McAllister, an associate scientist at the California Pacific Medical Center Research Institute in San Francisco.

The compound found in cannabis, called cannabidiol (CBD), inhibits a gene, Id-1, that researchers believe is responsible for the metastatic process that spreads cells from the original tumor throughout the body.”

http://abcnews.go.com/Health/Healthday/story?id=4509456&page=1

Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma

Posted on by

“Because cannabinoid receptor agonists are capable of reducing proliferation and inducing apoptosis (cell death) in diverse cancer cells such as glioma, breast cancer, and melanoma, we evaluated whether CB1 is a potential drug target in rhabdomyosarcoma.

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children…

 Our study shows that treatment with the cannabinoid receptor agonists HU210 (cloned THC from Hebrew University) and Delta(9)-tetrahydrocannabinol (THC from cannabis) lowers the viability of translocation-positive rhabdomyosarcoma cells through the induction of apoptosis…

These results support the notion that cannabinoid receptor agonists could represent a novel targeted approach for treatment of translocation-positive rhabdomyosarcoma.”

Full text: http://mct.aacrjournals.org/content/8/7/1838.long

The CB1 Cannabinoid Receptor Is Coupled to the Activation of c-Jun N-Terminal Kinase

Posted on by

“One of the most intriguing and unexplored actions of cannabinoids is their ability to control cell growth. Thus, cannabinoids have been shown to induce antiproliferative effects through the CB1 receptor… we have recently shown that cannabinoids are able to modulate through the CB1 receptor the activity of the PI3K/protein kinase B pathway, which serves as a pivotal antiapoptotic signal…”

http://molpharm.aspetjournals.org/content/58/4/814.long

Cannabinoids: A new hope for breast cancer therapy?

Posted on by

“Experimental evidence accumulated during the last decade supports that cannabinoids, the active components of Cannabis sativa and their derivatives, possess anticancer activity… these compounds exert anti-proliferative, pro-apoptotic, anti-migratory and anti-invasive actions in a wide spectrum of cancer cells… Moreover, tumor growth, angiogenesis and metastasis are hampered by cannabinoids… our current knowledge on the anti-tumor potential of cannabinoids in breast cancer… suggests that cannabinoid-based medicines may be useful for the treatment of most breast tumor subtypes.”

http://www.ncbi.nlm.nih.gov/pubmed/22776349 

Cannabis and tobacco smoke are not equally carcinogenic

Posted on by

“Cannabis and tobacco smoke are not equally carcinogenic… Cannabis smoke contains cannabinoids whereas tobacco smoke contains nicotine (plus added carcinogens). Available scientific data, that examines the carcinogenic properties of inhaling smoke and its biological consequences, suggests reasons why tobacco smoke, but not cannabis smoke, may result in lung cancer… Furthermore, compounds found in cannabis have been shown to kill numerous cancer types including: lung cancer, breast and prostate, leukemia and lymphoma, glioma, skin cancer, and pheochromocytoma…”-

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1277837/?tool=pubmed

Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation.

Posted on by

” Here, we show that Delta(9)-tetrahydrocannabinol (THC), through activation of CB(2) cannabinoid receptors, reduces human breast cancer cell proliferation by blocking the progression of the cell cycle and by inducing apoptosis… these data might set the bases for a cannabinoid therapy for the management of breast cancer.”

http://www.ncbi.nlm.nih.gov/pubmed/16818634

 

Cannabis Science Publishes List of Over 800 Peer-Reviewed Cannabis and Cancer References From Scientists Around the World

Posted on by

“This list of peer-reviewed manuscripts, provides support for the anecdotal observations of an increasing number of patients claiming successful cancer treatment using medical cannabis extracts.”

“The scientific documentation of the anti-cancer and anti-metastatic properties of cannabinoids is a driving force behind behind our long-term goal, to make high quality, effective, reliable and safe cannabis extracts available to the public beyond the borders of current medical marijuana states.”

http://www.drugs.com/clinical_trials/cannabis-science-publishes-list-over-800-peer-reviewed-cannabis-cancer-references-scientists-around-12716.html

https://www.cannabisscience.com/index.php/news-media/news-archive/215-cannabis-science-publishes-list-of-over-800-peer-reviewed-cannabis-and-cancer-references-from-scientists-around-the-world

Cannabis Science Reports: National Cancer Institute Updates Confirm Successful Cancer Treatments with Medical Cannabis

Posted on by

“As we’ve previously reported, one of the most interesting findings that has emerged since the discovery of the endocannabinoid system (marijuana like compounds produced by humans, and all vertebrates) is that cannabinoids have profound cancer-killing and anti-metastatic properties.

There is strong scientific support, demonstrated in tissue culture and animal studies, of the potent cancer killing properties of cannabinoids for such deadly cancers as glioma, lung cancer, breast and prostate cancer, leukemias and lymphomas, and as well as skin cancers.”

http://www.cannabisscience.com/index.php/news-media/news-archive/195-cannabis-science-reports-national-cancer-institute-updates-confirm-successful-cancer-treatments-with-medical-cannabis

“Cannabis Science, Inc. (OTCBB:CBIS), a pioneering US biotech company developing pharmaceutical cannabis products, is pleased to report a government released update on cancer treatments using medical cannabis (marijuana), updated March 17, 2011, summarizing how the treatment of cancer with cannabinoids goes beyond the simple treatment of symptoms and side effects by exhibiting possible direct antitumor activities.

This summary contains the following key information:

– Cannabis has been used for medicinal purposes for thousands of years prior to its current status as an illegal substance.

– Chemical components of Cannabis, called cannabinoids, activate specific receptors found throughout the body to produce pharmacologic effects, particularly in the central nervous system and the immune system.

– Cannabinoids may have benefits in the treatment of cancer-related side effects.

– The potential benefits of medicinal Cannabis for people living with cancer include antiemetic effects, appetite stimulation, pain relief, and improved sleep.

– Though no relevant surveys of practice patterns exist, it appears that physicians caring for cancer patients who prescribe medicinal Cannabis predominantly do so for symptom management.

– Unlike other commonly used drugs, cannabinoids are stored in adipose tissue and excreted at a low rate (half-life 1-3 days).

– Even abrupt cessation of cannabinoid intake is not associated with rapid declines in plasma concentrations that would precipitate severe or abrupt withdrawal symptoms or drug cravings.

Robert Melamede, Ph.D., Cannabis Science’s CEO stated, “As we’ve previously reported, one of the most interesting findings that has emerged since the discovery of the endocannabinoid system (marijuana like compounds produced by humans, and all vertebrates) is that cannabinoids have profound cancer-killing and anti-metastatic properties. There is strong scientific support, demonstrated in tissue culture and animal studies, of the potent cancer killing properties of cannabinoids for such deadly cancers as glioma, lung cancer, breast and prostate cancer, leukemias and lymphomas, and as well as skin cancers.

Currently the federal government prohibitionist position on cannabis is hindering the medical community by delaying vitally important clinical cannabis research.

 I was quite elated when I recently saw that the NCI posted on their webpage

“In the practice of integrative oncology, the health care provider may recommend medicinal Cannabis not only for symptom management but also for its possible direct antitumor effect.”

 I foolishly thought that finally there would be official recognition of the modern peer reviewed science that shows the cancer killing properties of cannabinoids. Sadly, this statement was removed, without comment, within hours of its posting.””

More: http://www.medicalnewstoday.com/releases/221024.php