Category Archives: Endocannabinoid System

The Cannabinergic System as a Target for Anti-inflammatory Therapies

Posted on by

“Cell-based experiments or in vivo animal testing suggest that regulation of the endocannabinoid circuitry can impact almost every major function associated with the immune system. These studies were assisted by the development of numerous novel molecules that exert their biological effects through the endocannabinoid system. Several of these compounds were tested for their effects on immune function, and the results suggest therapeutic opportunities for a variety of inflammatory diseases such as multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, allergic asthma, and autoimmune diabetes through modulation of the endocannabinoid system.”

http://www.ingentaconnect.com/content/ben/ctmc/2006/00000006/00000013/art00008

Cannabinoid type 1 receptors located on single-minded 1-expressing neurons control emotional behaviors.

Posted on by

“Cannabinoid type 1 receptors located on single-minded 1-expressing neurons control emotional behaviors… This study suggests that CB1 receptors located on Sim1-expressing neurons exert a tonic control on locomotor reactivity, unconditioned anxiety, and cued-fear expression under basal conditions as well as after acute or repeated stress.”

http://www.ncbi.nlm.nih.gov/pubmed/21920410

CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types

Posted on by

“Marijuana cannabinoid receptors (CBR), CB1 and CB2… CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types… results suggest that CBR expression is relatively constant across the human population.”

http://www.ncbi.nlm.nih.gov/pubmed/11727770

Expression of cannabinoid receptors and their gene transcripts in human blood cells.

Posted on by

Food for thought: ” Normal human volunteers who do not use marijuana have genes that encode for the marijuana (cannabinoid) receptor proteins… We therefore concluded that the existence of… Expression of cannabinoid receptors and their gene transcripts in human blood cells.”— Human blood contains cannabinoid receptors.

http://www.ncbi.nlm.nih.gov/pubmed/10621950

The endocannabinoid system and neurogenesis in health and disease.

Posted on by

Consuming plant cannabinoids leads to neurogenesis (birth of neurons), thanks to the endocannabinoid system.

“The endocannabinoid system exerts an important neuromodulatory function in different brain areas and is also known to be involved in the regulation of neural cell fate.

Thus, CB(1) cannabinoid receptors are neuroprotective in different models of brain injury, and their expression is altered in various neurodegenerative diseases. Recent findings have demonstrated the presence of a functional endocannabinoid system in neural progenitor cells that participates in the regulation of cell proliferation and differentiation.

In this Research Update, the authors address the experimental evidence regarding the regulatory role of cannabinoids in neurogenesis and analyze them in the context of those pathological disorders in which cannabinoid function and altered neuronal or glial generation is most relevant, for example, stroke and multiple sclerosis.”

Food for thought: endocannabinoid modulation of lipogenesis

Posted on by

TRUTH: “Cannabis has been used since antiquity for the treatment of many ailments, including pain, rheumatoid arthritis, epilepsy, and eating disorders…”— “And God said … herb bearing seed … it is GOOD … it shall be for FOOD.” – Genesis 1:29

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087183/?tool=pubmed