Cannabidiol appears to protect against long-term negative psychiatric effects of THC

“A study reported Sept. 5 by neuroscientists at Indiana University finds that a non-psychoactive compound in cannabis called cannabidiol, or CBD, appears to protect against the long-term negative psychiatric effects of THC, the primary psychoactive ingredient in cannabis.” https://www.news-medical.net/news/20170906/Cannabidiol-appears-to-protect-against-long-term-negative-psychiatric-effects-of-THC.aspx

“CBD may protect against psychiatric risk from high-THC cannabis strains. IU neuroscientists find cannabidiol reduces symptoms such as impaired memory in adolescent mice simultaneously exposed to THC”  https://news.iu.edu/stories/2017/09/iub/releases/06-cbd-study.html

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Adolescent cannabis use and brain systems supporting adult working memory encoding, maintenance, and retrieval

NeuroImage

“Given prior reports of adverse effects of cannabis use on working memory, an executive function with a protracted developmental course during adolescence, we examined associations between developmental patterns of cannabis use and adult working memory (WM) processes.

Within repeated cannabis users, greater levels of total cannabis use were associated with performance-related increases in dorsolateral prefrontal cortex (DLPFC) activation during maintenance. Surprisingly, however, at the group level, cannabis users generally performed better than participants who reported never using cannabis (faster RT, higher accuracy).” https://www.ncbi.nlm.nih.gov/pubmed/29253654 https://www.sciencedirect.com/science/article/pii/S1053811917310637

“Why Pot Smokers Scored Higher Than Nonsmokers on This Memory Test. Among a sample of 28-year-olds who took a working-memory test while undergoing an MRI brain scan, individuals who started smoking marijuana in adolescence performed just as well or even better than individuals who never smoked cannabis, the study found.” https://www.livescience.com/61574-adolescent-cannabis-use-memory-study.html

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