THC inhibits breast cancer cell proliferation through JunD

“Tetrahydrocannabinol is a potent inhibitor of proliferation in cultured breast cancer cells and exerts its effect through the JunD transcription factor complex, researchers report.

There is increasing evidence that cannabinoids, the active components of marijuana, possess antitumoral properties by inhibiting proliferation and angiogenesis or promoting apoptosis.

A previous study reported by MedWire News showed that cannabidiol, a non-toxic phytocannabinoid, can inhibit breast cancer spread in a rodent model of the disease.

In the present study, Cristina Sanchez (Complutense University, Madrid, Spain) and colleagues turned their attention to the more potent plant-derived cannabinoid, Δ9-tetrahydrocannabinol (THC).

“These findings point therefore to a new target to inhibit breast cancer progression, which may contribute to the design of efficient treatments for this malignancy,’ Sanchez et al conclude in the journal Oncogene.”

http://www.medwire-news.md/46/74849/Oncology/THC_inhibits_breast_cancer_cell_proliferation_through_JunD.html

Cannabis destroys cancer cells

“Scientists working in the UK have revealed that cannabis has the potential to destroy leukemia cells.

The team – based at Queen Mary’s School of Medicine and Dentistry in London – have followed up on their previous findings that the main active ingredient in cannabis, tetrahydrocannabinol (THC) has the potential to be used effectively against some forms of cancer.

THC has previously been shown to attack cancer cells by interfering with important growth-processing pathways, however its mechanism of doing so has remained a mystery. Now, Dr Liu and his colleagues, using microarray technology – allowing them to simultaneously detect changes in more than 18,000 genes in cells treated with THC – have begun to uncover the existence of processes through which THC can kill cancer cells and potentially promote survival.”

http://www.labnews.co.uk/news/cannabis-destroys-cancer-cells/

 

THC From Cannabis Destroys Cancer Cells

“The study results strongly suggest that if taken regularly, cannabis oil may be able to induce remission in leukemia patients without the horrendous side effects typically associated with standard radio-chemical treatment options. Although this is only one such study, other similar studies have shown equally impressive results.

 Many of the active ingredients found in cannabis-derived drugs show exceptional promise in treating some of the greatest hurdles facing modern medical science. In addition to their aforementioned capacity for safely treating certain forms of deadly cancer, they also show great promise in alleviating autoimmune conditions such as rheumatoid arthritis, multiple sclerosis, and even inflammatory bowel disease. A growing number of experts also note their possible viability treating a range of neurological disorders including Alzheimer’s and Lou Gehrig’s disease.”

http://www.globalhealingcenter.com/natural-health/thc-from-cannabis-destroys-cancer-cells/

The Data is Very Strong: Marijuana Plant Extract Stops Cancers From Spreading

” A compound found in cannabis could halt the spread of many forms of aggressive cancer, scientists say.

Researchers have now found that the compound, called cannabidiol, had the ability to ‘switch off’ the gene responsible for metastasis in an aggressive form of breast cancer. Importantly, this substance does not produce the psychoactive properties of the cannabis plant.

Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. CBD (Cannabidiol), one of the main constituents of the cannabis plant has been proven medically to relieve many diseases including the inhibition of cancer cell growth. Recent studies have shown it to be an effective atypical anti-psychotic in treating schizophrenia. CBD also interferes with the amount of THC your brain processes, balancing the psychotropic effect of marijuana. That is precisely why the power of raw cannabis is turning heads.”

http://myscienceacademy.org/2012/09/28/the-data-is-very-strong-marijuana-plant-extract-stops-cancers-from-spreading/

Marijuana May Fight Lung Tumors – CBSNews

“the active ingredient in marijuana may help combat lung cancer, new research suggests.

Moreover, other early research suggests the cannabis compound could help fight brain, prostate, and skin cancers as well, Preet says.

The finding builds on the recent discovery of the body’s own cannabinoid system, Preet says. Known as endocannabinoids, the natural cannabinoids stimulate appetite and control pain and inflammation.

THC seeks out, attaches to, and activates two specific endocannabinoids that are present in high amounts on lung cancer cells, Preet says. This revs up their natural anti-inflammatory properties. Inflammation can promote the growth and spread of cancer.

In the new study, the researchers first demonstrated that THC inhibited the growth and spread of cells from two different lung cancer cell lines and from patient lung tumors. Then, they injected THC into mice that had been implanted with human lung cancer cells. After three weeks, tumors shrank by about 50 percent, compared with tumors in untreated mice.”

 http://www.cbsnews.com/2100-500368_162-2696726.html

Marijuana Compound Fights Cancer; Human Trials Next

“The “medical” bit of medical marijuana may be legitimate after all: Turns out a component of cannabis fights cancer, according to research.

Scientists at California Pacific Medical Center found that cannabidiol, or CBD, has the ability to “turn off” the DNA that causes “breast and other types of cancers” to metastasize, according to the San Francisco Chronicle.

“If this plant were discovered in the Amazon today, scientists would be falling all over each other to be the first to bring it to market,” said Dr. Donald Abrams, chief of oncology at the University of California San Francisco, which has also found science behind marijuana’s efficacy.”

http://www.nbcbayarea.com/news/local/Marijuana-Compound-Fights-Cancer-Human-Trials-Next-170406116.html

Can Cannabidiol (CBD) Fight Metastatic Cancer? According to the latest research the answer is yes.

“The article states that scientists at California Pacific Medical Center who have been researching marijuana’s compounds for the 20 years have found that Cannabidiol, or CBD, has the ability to “turn off” the DNA that causes “breast and other types of cancers” to metastasize. CBD is the second-most abundant cannabinoid within marijuana, but does not cause the psychotropic high of THC.

As stated in the article: “We started by researching breast cancer,” said scientist Pierre Desprez. “But now we’ve found that Cannabidiol works with many kinds of aggressive cancers–brain, prostate–any kind in which these high levels of ID-1 are present.””

http://www.walb.com/story/19604192/can-cannabidiol-cbd-fight-metastatic-cancer-according-to-the-latest-research-the-answer-is-yes?fb_action_ids=446062188763761&fb_action_types=og.recommends&fb_source=aggregation&fb_aggregation_id=246965925417366

Marijuana compound could help fight breast cancer

“There may be a new weapon in the fight against aggressive forms of breast cancer in the future, and it comes from an unlikely source: Marijuana. Researchers at California Pacific Medical Center in San Francisco believe a compound in marijuana may help.

The research funded by the California Breast Cancer Research Program builds on more than a decade of studies involving the genes responsible for the spread of cancer. Now scientists have found at the cellular level, a compound in cannabis inhibits the gene that controls the spread of cancer.”

http://abclocal.go.com/kgo/story?section=news/health&id=5771385

Pot Helped Doctor Fight Cancer

“When Dan Shapiro was diagnosed with Hodgkins’ disease in 1987, he called a friend who had also battled cancer.

His friend’s advice, Shapiro says, came in a six-word package: “Cancer is grim, man, get weed.”

Shapiro, who’s been in remission for nine years, said the marijuana helped him stay functional despite the notoriously-debilitating chemotherapy. He wrote about his experiences in his recent book Mom’s Marijuana (Harmony, 2000).”

http://abcnews.go.com/US/story?id=93712&page=1

Marijuana Compound May Fight Lung Cancer – ABCNews

“the active ingredient in pot may help fight lung cancer, new research shows.

Harvard University researchers have found that, in both laboratory and mouse studies, delta-tetrahydrocannabinol (THC) cuts tumor growth in half in common lung cancer while impeding the cancer’s ability to spread.

The compound “seems to have a suppressive effect on certain lines of cancer cells,” explained Dr. Len Horovitz, a pulmonary specialist at Lenox Hill Hospital in New York City.

According to the researchers, THC fights lung cancer by curbing epidermal growth factor (EGF), a molecule that promotes the growth and spread of particularly aggressive non-small cell lung cancers.”

http://abcnews.go.com/Health/Healthday/story?id=4506595