“Cannabinoid receptor type 1 and 2 expression in the skin of healthy dogs and dogs with atopic dermatitis…The endocannabinoid system and cannabimimetic compounds protect against effects of allergic inflammatory disorders in various species of mammals. Results of the present study contributed to knowledge of the endocannabinoid system and indicated this system may be a target for treatment of immune-mediated and inflammatory disorders such as allergic skin diseases in dogs.”
Category Archives: Endocannabinoid System
CANNABINOIDS: POTENTIAL ANTICANCER AGENTS
The study by Manuel Guzmán of Madrid Spain found that cannabinoids, the active components of marijuana, inhibit tumor growth in laboratory animals. They do so by modulating key cell-signalling pathways, thereby inducing direct growth arrest and death of tumor cells, as well as by inhibiting the growth of blood vessels that supply the tumor.
The emerging role of the endocannabinoid system in cardiovascular disease
“… the EndoCannabinoid System has been implicated in a growing number of physiological functions of the nervous system and various peripheral organs, and its modulation turned out to hold tremendous therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders, neuropathic pain, multiple sclerosis, and spinal cord injury to cancer, glaucoma, osteoporosis, atherosclerosis, myocardial infarction, stroke, hypertension, and obesity/ metabolic syndrome to name just a few…”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791499/?tool=pubmed
The endocannabinoid system in prostate cancer
“Accumulating evidence indicate that the endocannabinoid system is dysregulated in prostate cancer… Overexpression of several components of the endocannabinoid system correlate with prostate cancer grade and progression, potentially providing a new therapeutic target for prostate cancer… several cannabinoids exert antitumoral properties against prostate cancer, reducing xenograft prostate tumor growth, prostate cancer cell proliferation and cell migration… the therapeutic potential of cannabinoids against prostate cancer is very promising…”
How many systems are there in a human?
“Endocannabinoid system is controlling human’s physiological development like motor abilities, memory and more. Also mood and pain feel is connecting to Endocannabinoid system.”
http://howmanyarethere.net/how-many-systems-are-there-in-a-human/
Alzheimer’s disease; taking the edge off with cannabinoids?
“Thus, cannabinoids offer a multi-faceted approach for the treatment of Alzheimer’s disease by providing neuroprotection and reducing neuroinflammation, whilst simultaneously supporting the brain’s intrinsic repair mechanisms by augmenting neurotrophin expression and enhancing neurogenesis. The evidence supporting a potential role for the cannabinoid system as a therapeutic target for the treatment of Alzheimer’s disease will be reviewed herewith.”
http://www.medicalmarijuanainc.com/index.php/alzheimer-s-disease
Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease
“CBD is able to modulate microglial cell function in vitro and induce beneficial effects in an in vivo model of AD. Given that CBD lacks psychoactivity, it may represent a novel therapeutic approach for this neurological disease.”
http://www.medicalmarijuanainc.com/index.php/alzheimer-s-disease
Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action
“These studies have suggested a wide range of possible therapeutic effects of cannabidiol on several conditions, including Parkinson’s disease, Alzheimer’s disease, cerebral ischemia, diabetes, rheumatoid arthritis, other inflammatory diseases, nausea and cancer.”
http://www.medicalmarijuanainc.com/index.php/alzheimer-s-disease
Cannabis Science Provides Physician’s Documentation That Confirms Successful Treatment of Skin Cancer
April 6, 2011 “We are pleased to announce that we have physician’s documentation that confirms the successful treatment of basal cell carcinoma that resulted from the application of a topical cannabis extract.”
The endocannabinoid system in amyotrophic lateral sclerosis
“The endocannabinoid system in amyotrophic lateral sclerosis… Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative condition… there is significant evidence that several neurotoxic mechanisms including excitotoxicity, inflammation and oxidative stress, all contribute to disease pathogenesis… there is increasing evidence that cannabinoids and manipulation of the endocannabinoid system may have therapeutic value in ALS, in addition to other neurodegenerative conditions. Cannabinoids exert anti-glutamatergic and anti-inflammatory actions through activation of the CB(1) and CB(2) receptors… cannabinoid agents also exert anti-oxidant actions… the ability of cannabinoids to target multiple neurotoxic pathways in different cell populations increase their therapeutic potential in the treatment of ALS.”