“Rosemary: A Cancer-Fighting Spice” http://www2.mdanderson.org/cancerwise/2011/05/rosemary-a-cancer-fighting-spice.html
“Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines…the extracts exhibited various cytotoxic effects against different cell lines…Rosemary extract is a potential candidate to be included in the anti-cancer diet…” http://www.ncbi.nlm.nih.gov/pubmed/20449663
“Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. The use of plants is as old as the mankind. Natural products are cheap and claimed to be safe… It is concluded that rosemary and its constituents especially caffeic acid derivatives such as rosmarinic acid have a therapeutic potential in treatment or prevention of bronchial asthma, spasmogenic disorders, peptic ulcer, inflammatory diseases, hepatotoxicity, atherosclerosis, ischaemic heart disease, cataract, cancer and poor sperm motility.” http://www.ncbi.nlm.nih.gov/pubmed/10641130
“Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer. This review focuses on the Mediterranean herb, rosemary, its polyphenolic diterpenes (carnosic acid and carnosol) and their role in chemoprevention of prostate cancer. Epidemiological studies suggest a reduced risk of cancer in patients consuming rosemary… These findings warrant further research to understand the potential of rosemary as a cancer chemopreventive agent in prostate cancer.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607075/
“Effect of rosemary polyphenols on human colon cancer cells: transcriptomic profiling and functional enrichment analysis…rosemary polyphenols…may contribute to colon cancer cell death… Carnosol, one of the main polyphenols in rosemary, poses strong antioxidant and chemopreventive activities. This diterpene has demonstrated anti-inflammatory and anticancer activities on prostate, skin, breast, leukemia, and colon cancer. Another rosemary diterpene, carnosic acid, has proven antiproliferative activity in colon cancer cells…” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534995/
“Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human coloncancer HCT116 cells… Carnosol, an active constituent of rosemary, has been reported to possess anti-inflammatory and anticancer activities.” http://www.ncbi.nlm.nih.gov/pubmed/24481553
“Carnosic acid inhibits the growth of ER-negative human breast cancer cells and synergizes with curcumin…Studies indicate that extracts and purified components, including carnosic acid, from the herb rosemary display significant growth inhibitory activity on a variety of cancers….Rosemary/carnosic acid, alone or combined with curcumin, may be useful to prevent and treat ER-negative breast cancer.” http://www.ncbi.nlm.nih.gov/pubmed/22828666
“Carnosic acid modulates Akt/IKK/NF-κB signaling by PP2A and induces intrinsic and extrinsic pathway mediatedapoptosis in human prostate carcinoma PC-3 cells. This study investigates the efficacy of carnosic acid (CA), a polyphenolic diterpene, isolated from the plant rosemary (Rosemarinus officinalis), on androgen-independent human prostate cancer PC-3 cells…may have the potential for use in the prevention and/or treatment of prostate cancer.” http://www.ncbi.nlm.nih.gov/pubmed/22453599
“Carnosic acid, a rosemary phenolic compound, induces apoptosis through reactive oxygen species-mediated p38 activation in human neuroblastoma IMR-32 cells. Carnosic acid (CA), a rosemary phenolic compound, has been shown to display anti-cancer activity.” http://www.ncbi.nlm.nih.gov/pubmed/21833842
“Carnosic acid inhibits proliferation and augments differentiation of human leukemic cells induced by 1,25-dihydroxyvitamin D3 and retinoic acid. Carnosic acid, the polyphenolic diterpene derived from rosemary, is a strong dietary antioxidant that exhibits antimutagenic properties in bacteria and anticarcinogenic activity in various cell and animal models…These results indicate that carnosic acid is capable of antiproliferative action in leukemic cells and can cooperate with other natural anticancer compounds in growth-inhibitory and differentiating effects.” http://www.ncbi.nlm.nih.gov/pubmed/12094616
“Carnosol-induced apoptosis and downregulation of Bcl-2 in B-lineage leukemia cells. Carnosol, a phenolic compound extracted from the herb rosemary has been reported to have anti-cancer activity… These results suggest that carnosol may be useful as a novel chemotherapeutic agent against B-lineage leukemias, and possibly other types of cancers that express high levels of the protective protein, Bcl-2.” http://www.ncbi.nlm.nih.gov/pubmed/11448532
“Carnosol, a dietary diterpene, displays growth inhibitory effects in human prostate cancer PC3 cells leading to G2-phase cell cycle arrest and targets the 5′-AMP-activated protein kinase (AMPK) pathway…These results suggest that carnosol targets multiple signaling pathways that include the AMPK pathway. The ability of carnosol to inhibit prostate cancer in vitrosuggests carnosol may be a novel agent for the management of prostate cancer” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994272/
“Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Rosemary (Rosmarinus officinalis), a culinary spice and medicinal herb, has been widely used in European folk medicine to treat numerous ailments. Many studies have shown that rosemary extracts play important roles in anti-inflammation, anti-tumor, and anti-proliferation in various in vitro and in vivo settings.” http://www.ncbi.nlm.nih.gov/pubmed/21112365
“Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. Discovery of the molecular targets of traditional medicine and its chemical footprints can validate the use of such medicine. In the present report, we investigated the effect of ursolic acid (UA), a pentacyclic triterpenoid found in rosemary and holy basil, on apoptosis induced by TRAIL. We found that UA potentiated TRAIL-induced apoptosis in cancer cells.” http://www.ncbi.nlm.nih.gov/pubmed/21156789
“Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia…The results of our study suggest that the use of polyphenol-rich rosemary preparations together with low calcemic vitamin D3 analogs may represent a novel effective and low-toxic approach to combination differentiation therapy of acute myeloid leukemias.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824511/
“Antiproliferation effect of Rosemary (Rosmarinus officinalis) on human ovarian cancer cells in vitro. Rosemary (Rosmarinus officinalis L.) is a popular culinary/medicinal herb. Recent studies have shown it has pharmacologic activities for cancerchemoprevention and therapy.” http://www.ncbi.nlm.nih.gov/pubmed/22325591
“Anti-proliferative and antioxidant properties of rosemary Rosmarinus officinalis.
Constituents in rosemary have shown a variety of pharmacological activities for cancer chemoprevention and therapy in in vitro and in vivo models.” http://www.ncbi.nlm.nih.gov/pubmed/17487414
“Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary. Carnosol and carnosic acid, two major components of rosemary extracts, have shown activity for cancer prevention and therapy…The anti-angiogenic activity of carnosol and carnosic acid could contribute to the chemopreventive, antitumoral and antimetastatic activities of rosemary extracts and suggests their potential in the treatment of other angiogenesis-related malignancies.” http://www.ncbi.nlm.nih.gov/pubmed/22173778
