For many patients, cannabis may offer the best medicinal pain relief yet discovered

by: Raw Michelle

“(NaturalNews) By the beginning of the 1980s, after a four decade long lockdown, a re-interest in cannabis arose in the scientific community. In 1982, the American Institute of Medicinepublished an intriguing report entitled “Marijuana and Health”. The report was a collection of tentative exploratory research and case studies of the use of cannabis as a medicine.

The reappearance of a powerful plant in human pharmacopeia

The studies provided a glimpse of something that intrigued health care researchers. While the plant’s effects were entirely congruent with the goal of healing, the methodology used by the plant’s chemicals was very different from those employed by typical pharmaceuticals. To developers, cannabis suddenly represented a precedent for a whole new type of medicine. With over 88 pharmacologically active substances, cannabis introduced hundreds of new compounds to the medical world. The institute’s report concluded that further research into cannabis’ potential would be of great value to the field.

However, further research was very limited, stifled by cannabis’ legal status and social stigma. The legal status forces researchers to expend an overwhelming amount of time and effort to get permission to conduct the studies. The social stigma causes institutes to be less likely to receive funding for the projects, and that researchers are sacrificing their reputation in the professional world. That also means most of the studies conducted are federally funded. Unfortunately, in addition, successful researchers will still have to face a further publication bias, as journals also risk their reputations and status when publishing cannabis related research. It is ironic that even within a scientific community, researchers are punished for being unbiased. As a result, outlets that focus solely on cannabis related research have arisen. Internet publications have opened a wide market for research that would have previously been buried.

Where opiates don’t quite cut it

Of the studies that have been conducted, most have focused on marijuana as a treatment for neuropathic pain, one of the earliest treatments for which physicians saw potential. Neuropathic pain results from nerve damage in which the cells experience difficulty communicating. This can happen from traumas like surgery, where nerve connections are severed, but continue trying to communicate news of the damage to the next cell over. Similarly, when new nerve cells are formed but not yet hooked into the neural highway, they sputter and spark, trying to achieve connection. The sensation can be very painful. Neuropathic pain is very common symptom of cancer. Tumour growth can crush nerve trunks as it bullies its way to more territory.

Sometimes just talking about it helps

Early studies demonstrate that cannabis is hugely effective in treating neuropathic pain. The cannabinoids allow nerve cells to reverse the communication path. Cells sending trauma notifications to the main trunk would normally continue doing so until the stimuli was resolved. From a practical standpoint, it is difficult to eliminate pain the moment it is recognised, but from a human level, once the person is cognizant of the problem, there is no benefit to remaining in pain. Cannabis simply tells the alarmed cell that authorities have been notified and that the problem will be resolved shortly. It doesn’t, as is popularly believed, relieve pain by making cells “stoned” or unfocused so as to disrupt communication.

The few studies have been conducted have returned agreeing with the American Medical Institute’s findings and recommendations. After only preliminary examination, cannabis presents itself as a powerful tool. More in-depth research is likely to further displace today’s most relied-upon pharmaceuticals.”

 
 
 

The Endocannabinoid System and Pain

Gallery

“Cannabis has been used for more than twelve thousand years and for many different purposes (i.e. fiber, medicinal, recreational). However, the endocannabinoid signaling system has only recently been the focus of medical research and considered a potential therapeutic target. Endocannabinoids … Continue reading Continue reading

Cannabinoids and pain.

Abstract

“Recent advances have dramatically increased our understanding of cannabinoid pharmacology: the psychoactive constituents of Cannabis sativa have been isolated, synthetic cannabinoids described and an endocannabinoid system identified, together with its component receptors, ligands and their biochemistry. Strong laboratory evidence now underwrites anecdotal claims of cannabinoid analgesia in inflammatory and neuropathic pain. Sites of analgesic action have been identified in brain, spinal cord and the periphery, with the latter two presenting attractive targets for divorcing the analgesic and psychotrophic effects of cannabinoids. Clinical trials are now required, but are hindered by a paucity of cannabinoids of suitable bioavailability and therapeutic ratio.”

http://www.ncbi.nlm.nih.gov/pubmed/11575713

[The pharmacology of cannabinoid derivatives: are there applications to treatment of pain?].

“OBJECTIVE:

To present the cannabinoid system together with recent findings on the pharmacology of these compounds in the treatment of pain.

DATA SOURCES:

Search through Medline database of articles published in French and English since 1966. Also use of other publications such as books on cannabis.

DATA SYNTHESIS:

Recent advances have dramatically increased our understanding of cannabinoid pharmacology. The psychoactive constituents of Cannabis sativa have been isolated, synthetic cannabinoids described and an endocannabinoid system identified, together with its component receptors and ligands. Strong laboratory evidence now underwrites anecdotal claims of cannabinoid analgesia in inflammatory and neuropathic pain. Sites of analgesic action have been identified in brain, spinal cord and the periphery, with the latter two presenting attractive targets for divorcing the analgesic and psychotrophic effects of cannabinoids. Clinical trials are now required, but are hindered by a paucity of cannabinoids of suitable bioavailability and therapeutic ratio.

CONCLUSION:

The cannabinoid system is a major target in the treatment of pain and its therapeutic potential should be assessed in the near future by the performance of new clinical trials.”

http://www.ncbi.nlm.nih.gov/pubmed/12134594

Cannabinoid analgesia as a potential new therapeutic option in the treatment of chronic pain.

Abstract

“OBJECTIVE:

To review the literature concerning the physiology of the endocannabinoid system, current drug development of cannabinoid agonists, and current clinical research on the use of cannabinoid agonists for analgesia.

DATA SOURCES:

Articles were identified through a search of MEDLINE (1966-August 2005) using the key words cannabis, cannabinoid, cannabi*, cannabidiol, nabilone, THC, pain, and analgesia. No search limits were included. Additional references were located through review of the bibliographies of the articles identified.

STUDY SELECTION AND DATA EXTRACTION:

Studies of cannabinoid agonists for treatment of pain were selected and were not limited by pain type or etiology. Studies or reviews using animal models of pain were also included. Articles that related to the physiology and pharmacology of the endocannabinoid system were evaluated.

DATA SYNTHESIS:

The discovery of cannabinoid receptors and endogenous ligands for these receptors has led to increased drug development of cannabinoid agonists. New cannabimimetic agents have been associated with fewer systemic adverse effects than delta-9-tetrahydrocannabinol, including recent development of cannabis medicinal extracts for sublingual use (approved in Canada), and have had promising results for analgesia in initial human trials. Several synthetic cannabinoids have also been studied in humans, including 2 cannabinoid agonists available on the international market.

CONCLUSIONS:

Cannabinoids provide a potential approach to pain management with a novel therapeutic target and mechanism. Chronic pain often requires a polypharmaceutical approach to management, and cannabinoids are a potential addition to the arsenal of treatment options.”

http://www.ncbi.nlm.nih.gov/pubmed/16449552

Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes

“Hemp, Cannabis sativa, is a coarse bushy annual plant with palmate leaves and clusters of small green flowers that grows wild in regions of mild or tropical weather and can attain a height of 3 metres. The genus name Cannabis is complemented by sativa (which means useful). Cannabis has indeed been used throughout history for a variety of purposes…

 Cannabis has been utilised for centuries throughout the world to alleviate disease. Its derivatives were named “panacea”, or “cure-all”, and were sold as a legal medicine, mainly for pain…

The discovery of cannabinoid receptors, their endogenous ligands, and the machinery for the synthesis, transport, and degradation of these retrograde messengers, has equipped us with neurochemical tools for novel drug design. Agonist-activated cannabinoid receptors, modulate nociceptive thresholds, inhibit release of pro-inflammatory molecules, and display synergistic effects with other systems that influence analgesia, especially the endogenous opioid system. Cannabinoid receptor agonists have shown therapeutic value against inflammatory and neuropathic pains, conditions that are often refractory to therapy…”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430692/

Cannabis stops the pain

“Ann Vernon would like to understand one thing about the lawmakers who oppose the medical use of cannabis.

“I think you would have to be pretty heartless if you’re faced with these absolutely desperate people . . . and they say this [cannabis] helps and you turn them down? I don’t know.”

It is a question Ms Vernon, who sufferers from chronic pain and post-traumatic stress disorder, asks herself often. The most recent occasion was last week when she was standing before a judge on charges of cultivating cannabis.

Ms Vernon, 40, had plants in her home because she uses cannabis to ease her chronic pain. When the judge heard her medical evidence, backed by her doctor, he discharged her without conviction.

“He listened to me talk about what it was like to live with constant pain.”

The mother of three has now vowed to devote her time to fighting for changes in the law to allow the use of cannabis for medical purposes.

It was a doctor who first suggested cannabis to Ms Vernon.

Years and years of chronic pain – she was thrown from a horse as a teen and later suffered complications from surgery – left the once-active woman bedridden and in constant agony.

Sitting and standing were so agonising she would cart a mattress from room to room just so she could lie down.

Conventional painkillers failed and eventually cannabis was recommended.

“At first I was like ‘Oh what!’ I’d smoked cannabis as a teenager . . . now and then,” she says. “But then you get that desperate you will try anything.”

The drug – ingested with a vapouriser she imported from Australia – worked.

“With cannabis I have quality of life. I’ve come so far now that clearly I am not bedridden.”

Ms Vernon says that, while cannabis comes with a high, medical users get used to that very quickly. “I don’t find the high from the cannabis anywhere near as debilitating as the high I was getting from normal painkillers.”

Cannabis also helps with sleep and with appetite. “I also had a huge amount of nausea and that just wipes it.”

But she says it is hard not to feel like a criminal: “I have never even had a traffic infringement notice, not a parking ticket, nothing. So, yes, breaking the law is awful. To be made to feel like a criminal for something a doctor recommended to me and has helped me is awful.”

Being allowed to grow cannabis for medicinal use would mean less harm to the community, she says.

“It is also very hard, and very expensive, to get decent-quality cannabis. The supply is inconsistent, you don’t know what you are getting.”

Medical-cannabis patients are rendered vulnerable, she says.

“Many of them are much worse off physically than me and can’t come forward to speak.

“Some of the things I have seen, some of the effects I’ve seen of people when they consume cannabis. I’ve seen people get some movement back in limb they’ve had no movement in for eight years.

“I can’t imagine how cold people have to be to stop them from using the one thing that helps them.””

http://www.stuff.co.nz/dominion-post/news/national/7992118/Cannabis-stops-the-pain

Targeting CB2 receptors and the endocannabinoid system for the treatment of pain.

Abstract

“The endocannabinoid system consists of the cannabinoid (CB) receptors, CB(1) and CB(2), the endogenous ligands anandamide (AEA, arachidonoylethanolamide) and 2-arachidonoylglycerol (2-AG), and their synthetic and metabolic machinery. The use of cannabis has been described in classical and recent literature for the treatment of pain, but the potential for psychotropic effects as a result of the activation of central CB(1) receptors places a limitation upon its use. There are, however, a number of modern approaches being undertaken to circumvent this problem, and this review represents a concise summary of these approaches, with a particular emphasis upon CB(2) receptor agonists. Selective CB(2) agonists and peripherally restricted CB(1) or CB(1)/CB(2) dual agonists are being developed for the treatment of inflammatory and neuropathic pain, as they demonstrate efficacy in a range of pain models. CB(2) receptors were originally described as being restricted to cells of immune origin, but there is evidence for their expression in human primary sensory neurons, and increased levels of CB(2) receptors reported in human peripheral nerves have been seen after injury, particularly in painful neuromas. CB(2) receptor agonists produce antinociceptive effects in models of inflammatory and nociceptive pain, and in some cases these effects involve activation of the opioid system. In addition, CB receptor agonists enhance the effect of mu-opioid receptor agonists in a variety of models of analgesia, and combinations of cannabinoids and opioids may produce synergistic effects. Antinociceptive effects of compounds blocking the metabolism of anandamide have been reported, particularly in models of inflammatory pain. There is also evidence that such compounds increase the analgesic effect of non-steroidal anti-inflammatory drugs (NSAIDs), raising the possibility that a combination of suitable agents could, by reducing the NSAID dose needed, provide an efficacious treatment strategy, while minimizing the potential for NSAID-induced gastrointestinal and cardiovascular disturbances. Other potential “partners” for endocannabinoid modulatory agents include alpha(2)-adrenoceptor modulators, peroxisome proliferator-activated receptor alpha agonists and TRPV1 antagonists. An extension of the polypharmacological approach is to combine the desired pharmacological properties of the treatment within a single molecule. Hopefully, these approaches will yield novel analgesics that do not produce the psychotropic effects that limit the medicinal use of cannabis.”

http://www.ncbi.nlm.nih.gov/pubmed/19150370

Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.

“BACKGROUND:

  β-caryophyllene (BCP) is a common constitute of the essential oils of numerous spice, food plants and major component in Cannabis. The present study investigated the contribution of peripheral cannabinoid (CB) and opioid systems in the antinociception produced by intraplantar (i.pl.) injection of BCP. The interaction between peripheral BCP and morphine was also examined.”

“CONCLUSIONS:

The present results demonstrate that antinociception produced by i.pl. BCP is mediated by activation of CB(2) receptors, which stimulates the local release from keratinocytes of the endogenous opioid β-endorphin. The combined injection of morphine and BCP may be an alternative in treating chemogenic pain.”

http://www.ncbi.nlm.nih.gov/pubmed/23138934

Seizure exacerbation in two patients with focal epilepsy following marijuana cessation.

Abstract

“While animal models of epilepsy suggest that exogenous cannabinoids may have anticonvulsant properties, scant evidence exists for these compounds’ efficacy in humans. Here, we report on two patients whose focal epilepsy was nearly controlled through regular outpatient marijuana use. Both stopped marijuana upon admission to our epilepsy monitoring unit (EMU) and developed a dramatic increase in seizure frequency documented by video-EEG telemetry. These seizures occurred in the absence of other provocative procedures, including changes to anticonvulsant medications. We review these cases and discuss mechanisms for the potentially anticonvulsant properties of cannabis, based on a review of the literature.”

http://www.ncbi.nlm.nih.gov/pubmed/23159379