“Cannabinoids and opioids produce antinociceptive synergy. Cannabinoids such as Δ-9-tetrahydrocannabinol (THC) release endogenous opioids and endocannabinoids such as anandamide (AEA) also alter endogenous opioid tone. Opioids and cannabinoids bind distinct receptors that co-localize in areas of the brain involved with the processing of pain signals. Therefore, it is logical to look at interactions of these two systems in the modulation of both acute and chronic pain. This review summarizes the data indicating that with cannabinoid/opioid therapy one may be able to produce long-term antinociceptive effects at doses devoid of substantial side effects, while preventing the neuronal biochemical changes that accompany tolerance. The clinical utility of modulators of the endocannabinoid system as a potential mimic for THC-like drugs in analgesia and tolerance-sparing effects of opioids is a critical future direction also addressed in the review.” https://www.tandfonline.com/doi/abs/10.1080/09540260902782794]]>
Tag Archives: marijuana
[The impact of cannabinoids on the endocrine system].
“Cannabinoids are naturally occurring compounds, derivatives of Indian hemp, in which tetrahydrocannabinol (THC) is the most important. Marijuana, hashish and hash oil are among those most commonly used in the group.
Cannabinoids (marjhuana and hashish) have been used throughout recorded history as effective drugs in treating various diseases and conditions such as: malaria, hypertension, constipation, bronchial asthma, rheumatic pains, and as natural pain relief in labour and joint pains.
Marijuana acts through cannabinoid receptors CB 1 and CB2. Both receptors inhibit cAMP accummulation (through Gi/o proteins) and stimulate mitrogen- activated protein kinase. CB1 rceptors are located in CNS and in adipose tissue, digestive tract, muscles, heart, lungs, liver, kidneys, gonads, prostate gland and other peripheral tissues. CB2 cannabinoid receptors are located in the peripheral nervous system (at the ends of peripheral nerves), and on the surfaces of the cells of the immunological system.
The discovery of endogenous cannabinoids has contributed to a better understanding of their role in the regulation of the intake of food, energetic homeostasis and their significant influence on the endocrine system.”
Hemp shows potential for treating ovarian cancer
“Researchers demonstrate hemp’s ability to slow cancer growth and uncover mechanism for its cancer-fighting ability.
Results from some of the first studies to examine hemp’s ability to fight cancer show that it might one day be useful as plant-based treatment for ovarian cancer. Hemp is part of the same cannabis family as marijuana but doesn’t have any psychoactive properties or cause addiction. “Hemp, like marijuana, contains therapeutically valuable components such as cannabidiol, cannabinol, and tetrahydrocannabinol,” “Our findings from this research as well as prior research show that KY hemp slows ovarian cancer comparable to or even better than the current ovarian cancer drug Cisplatin,” said Turner. “Since Cisplatin exhibits high toxicity, we anticipate that hemp would carry less side effects.” https://www.sciencedaily.com/releases/2018/04/180423155046.htm“Hemp Shows Potential for Treating Ovarian Cancer” https://www.eurekalert.org/multimedia/pub/167927.php
“Hemp Can Fight Cancer Too, Reveal Scientists in New Cannabis Study” https://www.inverse.com/article/44039-cancer-hemp-plant-based-treatment
“Studies show hemp’s potential for treating ovarian cancer” https://www.news-medical.net/news/20180424/Studies-show-hemps-potential-for-treating-ovarian-cancer.aspx
“Hemp shows potential for treating ovarian cancer” https://www.europeanpharmaceuticalreview.com/news/75103/hemp-treating-ovarian-cancer/
“Hemp portrays possibility for curing ovarian cancer” https://ebuzzcommunity.com/2018/04/hemp-portrays-possibility-for-curing-ovarian-cancer/
“Hemp Extract Inhibits Growth Of Ovarian Cancer, Research Finds” https://thefreshtoast.com/rx/hemp-extract-inhibits-growth-of-ovarian-cancer-research-finds/
]]>Marijuana Use by Adolescents and Young Adults with Inflammatory Bowel Disease.
“Marijuana use by adolescents and young adults with IBD is common and perceived as beneficial.” https://www.ncbi.nlm.nih.gov/pubmed/29673723 http://www.jpeds.com/article/S0022-3476(18)30388-3/fulltext]]>
Dronabinol oral solution in the management of anorexia and weight loss in AIDS and cancer.
“The true incidence of anorexia secondary to human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) and cancer is not well classified owing to the fact that there is a lack of standardized definitions and recent clinical data in these settings.
Dronabinol, or Δ-9-tetrahydrocannabinol, is a synthetic molecule that closely mimics the action of Cannabis sativa L., a naturally occurring compound activated in the central nervous system by cannabinoid receptors.
Dronabinol exerts its effects by directly acting on the vomiting and appetite control centers in the brain, which in turn increases appetite and prevents vomiting.
In the USA, dronabinol is currently available in two dosage formulations – oral capsule and oral solution. While the oral capsule was initially approved by the US Food and Drug Administration in 1985, the recent approval of the oral solution in 2016 presents an “easy-to-swallow” alternative for patients using or intending to use dronabinol.
Dronabinol is indicated in adult patients with HIV/AIDS for the treatment of anorexia and weight loss. However, there is no approved indication in the setting of cancer-related anorexia and weight loss. This review aims at presenting available data on the use of oral dronabinol in the management of anorexia and weight loss in HIV/AIDS and cancer, as well as characterizing and highlighting the pharmacotherapeutic considerations of the newest formulation of dronabinol.”
“Δ9-THC and cannabidiol (CBD) are two main 
“Symptom management in older adults, including pain and distressing non-pain symptoms, can be challenging. Medications can cause side effects that worsen quality of life or create other symptoms, and polypharmacy itself can be detrimental in older adults.