Anti Proliferative and Pro Apoptotic Effects of Flavonoid Quercetin Are Mediated by CB1 Receptor in Human Colon Cancer Cell Lines.

Posted on by

“Quercetin, the major constituent of flavonoid and widely present in fruits and vegetables, is an attractive compound for cancer prevention due to its beneficial anti proliferative effects, showing a crucial role in the regulation of apoptosis and cell cycle signaling.

In vitro studies have demonstrated that quercetin specifically influences colon cancer cell proliferation.

Our experiments, using human colon adenocarcinoma cells, confirmed the anti proliferative effect of quercetin and gave intriguing new insight in to the knowledge of the mechanisms involved…

These findings open new perspectives for anticancer therapeutic strategies.”

http://www.ncbi.nlm.nih.gov/pubmed/25893829

“Flavonoid glycosides and cannabinoids from the pollen of Cannabis sativa L.”  http://www.ncbi.nlm.nih.gov/pubmed/15688956

Marijuana extract slashes pediatric seizures, landmark study confirms

Posted on by

Cannabis extract Epidiolex slashes seizures, a new study confirms. (Photo by GW Pharmaceuticals)

“A batch of studies further confirms medical cannabis patients are right to try cannabidiol-rich marijuana products to treat intractable seizure disorders.

Three studies presented at the American Epilepsy Society’s 69th Annual Meeting in Philadelphia Dec. 7th found a marijuana-derived extract slashed pediatric seizures in half, and completely stopped seizures in nine percent of cases.”  http://blog.sfgate.com/smellthetruth/2015/12/15/marijuana-extract-slashes-pediatric-seizures-landmark-study-confirms/

“Study: marijuana medicine is safe, very effective on epilepsy” http://blog.sfgate.com/smellthetruth/2015/05/12/study-marijuana-medicine-is-safe-very-effective-on-epilepsy/

http://www.thctotalhealthcare.com/category/epilepsy-2/

Cannabidiol Effective and Safe at 3 Months for Epilepsy

Posted on by

“New open-label data from the expanded-access treatment program involving the cannabidiol Epidiolex(GW Pharma) show the median reduction in frequency of convulsive seizures after 3 months of treatment was 45% in all patients but higher in those with Dravet syndrome, among the most severe types of epilepsy.

The data are “very positive and promising,” said lead author Orrin Devinsky, MD, professor, neurology, neurosurgery and psychiatry, and director, New York University Comprehensive Epilepsy Center.” http://www.medscape.com/viewarticle/855768

“More Positive Results With Cannabidiol in Epilepsy”  http://www.medscape.com/viewarticle/853781

http://www.thctotalhealthcare.com/category/epilepsy-2/

Study: Marijuana-derived drug reduces epileptic seizures

Posted on by

“A new study involving 11 epilepsy centers across the United States shows that a drug made from a medical marijuana derivative can reduce seizures in children and young adults with epilepsy who don’t find relief from other treatments.

Almost a third of patients with epilepsy don’t respond to standard treatments, and marijuana-based medicines have drawn interest as having potential benefits, but scientific data on their effectiveness has been slim until now.

The new research involved 137 patients between the ages of one and 30 years old. It found that a medical marijuana derivative called cannabidiol (CBD) helped reduce seizure frequency in most children and young adults enrolled in the yearlong study.

Cannabidiol was also well-tolerated and safe, lead author Dr. Orrin Devinsky, professor of neurology, neurosurgery, and psychiatry and director of the Comprehensive Epilepsy Center at NYU Langone Medical Center, told CBS News.”

http://www.cbsnews.com/news/marijuana-derived-drug-reduces-seizures-in-hard-to-treat-epilepsy/

“Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial.” http://www.ncbi.nlm.nih.gov/pubmed/26724101

http://www.thctotalhealthcare.com/category/epilepsy-2/

Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial.

Posted on by

“Cannabis-based treatments for epilepsy have generated much interest…

We aimed to establish whether addition of cannabidiol to existing anti-epileptic regimens would be safe, tolerated, and efficacious in children and young adults with treatment-resistant epilepsy…

Our findings suggest that cannabidiol might reduce seizure frequency and might have an adequate safety profile in children and young adults with highly treatment-resistant epilepsy.”

http://www.ncbi.nlm.nih.gov/pubmed/26724101

http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)00379-8/fulltext

http://www.thctotalhealthcare.com/category/epilepsy-2/

NEW SLEEP APNEA PILL DERIVED FROM CANNABIS

Posted on by

ABC7 Los Angeles

“Sleep apnea, a condition affecting more than 12 million Americans, can lead to a host of health problems, including heart disease, and a new treatment containing ingredients derived from cannabis is being developed to help those with the disorder.”

http://abc7.com/health/new-sleep-apnea-pill-derived-from-cannabis/1141400/

http://www.thctotalhealthcare.com/category/sleep-apnea/

Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: Role of 5-HT1A receptors.

Posted on by

“Cannabidiol (CBD), the main non-psychotomimetic component of marihuana…

…we have evaluated the effects of CBD following acute and chronic administration in the olfactory bulbectomy mouse model of depression…

In conclusion, our findings indicate that CBD could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate cortical signalling through a 5-HT1A receptor-dependent mechanism.”

http://www.ncbi.nlm.nih.gov/pubmed/26711860

Cannabis to lower blood pressure!

Posted on by

News Medical - Life Sciences & Medicine

“A new method for lowering blood pressure (hypertension) through use of a compound that synthesizes a cannabis (hashish) plant component has been developed by a pharmacology Ph.D. student at the Hebrew University of Jerusalem School of Pharmacy.

Cardiovascular disease (CVD) accounts for about one-third of all deaths in industrialized countries, and is the leading reason for visits there to physicians as well as for drug prescriptions. However, not all patients respond well to the drugs available. There is no “ideal’ hypotensive (blood pressure lowering) drug.

The cannabis plant – also known as hashish or marijuana – through its chemical compounds — cannabinoids — has been shown to have a beneficial, hypotensive effect.”

http://www.news-medical.net/news/2006/06/19/18517.aspx

Report shows relationship between sensation seeking, reward sensitivity and cannabis use

“Lowering Of Blood Pressure Achieved Through Use Of Hashish-like Drug”  http://www.sciencedaily.com/releases/2006/06/060620083025.htm

http://www.thctotalhealthcare.com/category/hypertension-high-blood-pressure/

Use of Cannabinoids for Spasticity and Pain Management in MS.

Posted on by

“Several randomized trials have demonstrated potential benefit of cannabis derivatives in the symptomatic treatment of multiple sclerosis (MS) patients. These provide class 1 and 2 evidence for cannabinoid product use for spasticity and pain in these patients. The precise best ratio or doses are not yet clear. The safety and potential long-term effects of these products on cognitive function in people with MS have not been evaluated. Since short-term memory and processing speed can be significantly impaired in many people with MS, the concern of potential cognitive impairment related to cannabis products needs consideration in clinical care and should be addressed in longer, prospective studies.”

http://www.ncbi.nlm.nih.gov/pubmed/26705757

Cannabinoid receptor-specific mechanisms to ameliorate pain in sickle cell anemia via inhibition of mast cell activation and neurogenic inflammation.

Posted on by

“Sickle cell anaemia is a manifestation of a single point mutation in haemoglobin, but inflammation and pain are the insignia of this disease which can start in infancy and continue throughout life.

Earlier studies showed that mast cell activation contributes to neurogenic inflammation and pain in sickle mice.

Morphine is the common analgesic treatment but also remains a major challenge due to the side effects and ability to activate mast cells. Therefore, we examined the cannabinoid receptor-specific mechanisms to ameliorate mast cell activation, neurogenic inflammation and hyperalgesia, using HbSS-BERK sickle and cannabinoid receptor 2 deleted sickle mice.

We show that cannabinoids ameliorate mast cell activation, inflammation and neurogenic inflammation in sickle mice via both cannabinoid receptors 1 and 2.

Thus, cannabinoids influence systemic and neural mechanisms, ameliorating the disease pathobiology and hyperalgesia in sickle mice.

This study provides a “proof of principle” for the potential of cannabinoid/cannabinoid receptor-based therapeutics to treat several manifestations of sickle cell anaemia.”