Tag Archives: cannabis

Advances in the management of multiple sclerosis spasticity: multiple sclerosis spasticity nervous pathways.

Posted on by

“Involvement of the endocannabinoid system in pathophysiological mechanisms responsible for spasticity has been demonstrated in animal models of MS…

Evidence indicates that the antispasticity effects of THC:CBD oromucosal spray (Sativex®) are associated with enhanced cortical long-term potentiation.

CB1 receptors, which are associated with movement, postural control, and pain and sensory perception, influence glutamatergic pathways.

THC:CBD oromucosal spray was shown to reverse motor cortex plasticity from long-term depression through long-term potentiation of synaptic transmission, thereby restoring, at least in part, effective corticospinal inputs to spinal circuits.”

http://www.ncbi.nlm.nih.gov/pubmed/25278116

http://www.thctotalhealthcare.com/category/multiple-sclerosis-ms/

Cannabis oil stopped my cancer says Lake Macquarie’s Susannah Patch

Posted on by

“A LAKE Macquarie woman whose ‘‘aggressive’’ breast cancer spread to various parts of her body including her spine and lungs credits her remarkable recovery to cannabis oil.

Awaba woman Susannah Patch, 44, is one of a growing number of Hunter people who have treated themselves using an underground network of cannabis oil suppliers.

Although she had surgery, radiotherapy and chemotherapy, Ms Patch says most of her improvement has come since stopping chemotherapy against the advice of the cancer specialists and continuing with cannabis oil…

‘It is a distinct possibility that the cannabinoids may have ‘‘a place in the future treatment of cancer,’’

http://www.theherald.com.au/story/2587931/cannabis-oil-stopped-my-cancer/?cs=12

“It’s breast cancer awareness month. Please, BE AWARE:” http://www.thctotalhealthcare.com/its-breast-cancer-awareness-month-please-be-aware/

“A laboratory study of cannabidiol in estrogen receptor positive and estrogen receptor negative breast cancer cells showed that it caused cancer cell death while having little effect on normal breast cells.” http://www.cancer.gov/cancertopics/pdq/cam/cannabis/patient/page2

“Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells… In summary, we showed that CBD, a plant-derived cannabinoid, preferentially kills breast cancer cells…” http://mct.aacrjournals.org/content/10/7/1161.full

“Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa,” http://www.ncbi.nlm.nih.gov/pubmed/19690824

“Cannabidiol (CBD) Shown To Kill Breast Cancer Cells” http://www.cafemom.com/group/99198/forums/read/19190923/Cannabidiol_CBD_Shown_To_Kill_Breast_Cancer_Cells

“Here, we show that Δ9-tetrahydrocannabinol (THC), reduces human breast cancer cell proliferation by blocking the progression of the cell cycle and by inducing apoptosis.” http://www.ncbi.nlm.nih.gov/pubmed/16818634

“Programmed Cell Death (Apoptosis)” http://www.ncbi.nlm.nih.gov/books/NBK26873/

“Cannabis has been shown to kill cancer cells…”
http://www.cancer.gov/cancertopics/pdq/cam/cannabis/patient/page1

“…cannabinoids may be able to kill cancer cells while protecting normal cells… A laboratory study of delta-9-THC… showed that it damaged or killed the cancer cells… A laboratory study of cannabidiol… showed that it caused cancer cell death…” http://www.cancer.gov/cancertopics/pdq/cam/cannabis/patient/page2

“Cannabinoids appear to kill tumor cells but do not effect their nontransformed counterparts and may even protect them from cell death.” http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4

“Cannabis oil stopped my cancer says Lake Macquarie’s Susannah Patch” http://www.theherald.com.au/story/2587931/cannabis-oil-stopped-my-cancer/?cs=12

http://www.thctotalhealthcare.com/category/breast-cancer/

Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid.

Posted on by

“Cannabigerol (CBG) is a safe non-psychotropic Cannabis-derived cannabinoid which interacts with specific targets involved in carcinogenesis…

Here, we investigated whether CBG protects against colon tumorigenesis.

In vivo, CBG inhibited the growth of xenograft tumors as well as chemically-induced colon carcinogenesis.

CBG hampers colon cancer progression in vivo and selectively inhibits the growth of colorectal cancer cells, an effect shared by other TRPM8 antagonists.

CBG should be considered translationally in colorectal cancer prevention and cure.”

http://www.ncbi.nlm.nih.gov/pubmed/25269802

http://www.thctotalhealthcare.com/category/colon-cancer/

Δ(9)-tetrahydrocannabinol targeting estrogen receptor signaling: the possible mechanism of action coupled with endocrine disruption.

Posted on by

“Δ(9)-Tetrahydrocannabinol (Δ(9)-THC), a biologically active constituent of marijuana, possesses a wide variety of pharmacological and toxicological effects (e.g., analgesia, hypotension, reduction of inflammation, and anti-cancer effects).

Among Δ(9)-THC’s biological activities, its recognized anti-estrogenic activity has been the subject of investigations.

… Δ(9)-THC is used as both a drug of abuse (marijuana) and as a preventive therapeutic to treat pain and nausea in cancer patients undergoing chemotherapy…

…important to investigate the mechanistic basis underlying the anti-estrogenic activity of Δ(9)-THC…

We have recently reported that ERβ, a second type of ER, is involved in the Δ(9)-THC abrogation of E2/ERα-mediated transcriptional activity. Here we discuss the possible mechanism(s) of the Δ(9)-THC-mediated disruption of E2/ERα signaling by presenting our recent findings as well.”

http://www.ncbi.nlm.nih.gov/pubmed/25177025

 

Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells.

Posted on by

“Metastases are known to be responsible for approximately 90% of breast cancer-related deaths.

Cyclooxygenase-2 (COX-2) is involved not only in inflammatory processes, but also in the metastasis of cancer cells…

…cannabidiolic acid (CBDA), a selective COX-2 inhibitor found in the fiber-type cannabis plant…

Taken together, the results obtained here demonstrated that i) CBDA had dual inhibitory effects on COX-2 through down-regulation and enzyme inhibition, and ii) CBDA may possess the ability to suppress genes that are positively involved in the metastasis of cancer cells in vitro.”

http://www.ncbi.nlm.nih.gov/pubmed/25242400

“Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis…Taken together, these lines of evidence in this study suggest that naturally occurring CBDA in cannabis is a selective inhibitor for COX-2.”  http://dmd.aspetjournals.org/content/36/9/1917.long

“Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration… The data presented in this report suggest for the first time that as an active component in the cannabis plant, CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers.”  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009504/

http://www.thctotalhealthcare.com/category/breast-cancer/

The endocannabinoid system as a potential therapeutic target for pain modulation.

Posted on by

“Although cannabis has been used for pain management for millennia, very few approved cannabinoids are indicated for the treatment of pain and other medical symptoms.

Cannabinoid therapy re-gained attention only after the discovery of endocannabinoids and fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the enzymes playing a role in endocannabinoid metabolism.

Nowadays, research has focused on the inhibition of these degradative enzymes and the elevation of endocannabinoid tonus locally; special emphasis is given on multi-target analgesia compounds, where one of the targets is the endocannabinoid degrading enzyme.

In this review, I provide an overview of the current understanding about the processes accounting for the biosynthesis, transport and metabolism of endocannabinoids, and pharmacological approaches and potential therapeutic applications in this area, regarding the use of drugs elevating endocannabinoid levels in pain conditions.”

http://www.ncbi.nlm.nih.gov/pubmed/25207181

http://www.thctotalhealthcare.com/category/pain-2/

The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease.

Posted on by

“Alzheimer’s disease (AD) is the most common form of progressive neurodegenerative disease characterized by cognitive impairment and mental disorders… AD is multifaceted in nature and is linked to different multiple mechanisms in the brain…

The ideal treatment for AD should be able to modulate the disease through multiple mechanisms rather than targeting a single dysregulated pathway.

Recently, the endocannabinoid system emerged as novel potential therapeutic target to treat AD.

In fact, exogenous and endogenous cannabinoids seem to be able to modulate multiple processes in AD, although the mechanisms that are involved are not fully elucidated.

This review provides an update of this area. In this review, we recapitulate the role of endocannabinoid signaling in AD and the probable mechanisms through which modulators of the endocannabinoid system provide their effects, thus highlighting how this target might provide more advantages over other therapeutic targets.”

http://www.ncbi.nlm.nih.gov/pubmed/25147120

http://www.thctotalhealthcare.com/category/alzheimers-disease-ad/

THC for Huntington’s Disease? CB1 receptors important for more than drug use

Posted on by

Psychology Today: Here to Help

“Smoking marijuana doesn’t have to be a bad thing – Especially if you have HD.

The idea that THC can be used to relieve disease symptoms isn’t a new thing – Glaucoma, HIV, and cancer patients have all benefited from the use of CB1 agonists whether in the form of marijuana leaves or a pharmacologically similar product (like dronabinol).

Nevertheless, the idea of using THC or other CB1 agonists for the treatment of HD is pretty new…

The results of this study suggest that THC and other CB1 compounds may not only be able to improve symptoms in already symptomatic HD patients, but also slow down the progression of such a devestating disease.

Good news all around and a great use of THC as far as I’m concerned (medical use and removal from schedule-1 anyone?!).”

http://www.psychologytoday.com/blog/all-about-addiction/201102/thc-huntingtons-disease-cb1-receptors-important-more-drug-use

http://www.thctotalhealthcare.com/category/huntingtons/

Cannabis-Based Medicine Reduces Multiple Pathological Processes in AβPP/PS1 Mice.

Posted on by

“Several recent findings suggest that targeting the endogenous cannabinoid system can be considered as a potential therapeutic approach to treat Alzheimer’s disease (AD).

The present study supports this hypothesis demonstrating that delta-9-tetrahydrocannabinol (THC) or cannabidiol (CBD) botanical extracts, as well as the combination of both natural cannabinoids, which are the components of an already approved cannabis-based medicine, preserved memory in AβPP/PS1 transgenic mice when chronically administered during the early symptomatic stage.

Moreover, THC + CBD reduced learning impairment in AβPP/PS1 mice.

…suggesting a cannabinoid-induced reduction in the harmful effect of the most toxic form of the Aβ peptide.

Among the mechanisms related with these positive cognitive effects, the anti-inflammatory properties of cannabinoids may also play a relevant role…

In summary, the present findings show that the combination of THC and CBD exhibits a better therapeutic profile than each cannabis component alone and support the consideration of a cannabis-based medicine as potential therapy against AD.”

Growing medicine: Small-scale cannabis cultivation for medical purposes in six different countries.

Posted on by

“The production and consumption of cannabis for the treatment of medical conditions is of increasing importance internationally…

Growing cannabis for medical purposes was widespread.

The majority of medical growers reported cultivating cannabis for serious conditions…

There is a wider demand for licit access for medical cannabis than currently available…

many medical growers are using cannabis to treat serious medical conditions without proper medical advice and doctor’s guidance.”

http://www.ncbi.nlm.nih.gov/pubmed/25123694