Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis.

“Anandamide (AEA) is a lipid mediator that participates in the regulation of several reproductive functions.

This study investigated the endocannabinoid system in normal (NP) and preeclamptic (PE) placentas, and analyzed the potential functional role of AEA in the regulation of nitric oxide synthesis…

These data suggest that AEA may be one of the factors involved in the regulation of NOS activity in normal and preeclamptic placental villous.

Interestingly, the differential expression of NAPE-PLD and FAAH suggests that AEA could play an important role in the pathophysiology of PE.”

http://www.ncbi.nlm.nih.gov/pubmed/23122699

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Decreased circulating anandamide levels in preeclampsia.

“The endocannabinoid system has a key role in female reproduction, including implantation, decidualization and placentation. A growing number of studies indicate that placental and peripheral blood anandamide levels correlate closely with both spontaneous miscarriage and ectopic pregnancy.

Anandamide has also been implicated in blood pressure regulation.

In this study, we aimed to determine circulating anandamide levels in preeclampsia for the first time in the literature…

In conclusion, we demonstrated for the first time in the literature that serum anandamide concentrations are decreased in women with preeclampsia.”

http://www.ncbi.nlm.nih.gov/pubmed/25716652

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Emerging targets and therapeutic approaches for the treatment of osteoarthritis pain.

“Osteoarthritis is a complex and often painful disease that is inadequately controlled with current analgesics. This review discusses emerging targets and therapeutic approaches that may lead to the development of better analgesics…

Aberrant excitability in peripheral and central pain pathways drives osteoarthritis pain, reversing this via modulation of nerve growth factor, voltage-gated sodium channel, voltage-gated calcium channel and transient receptor potential vanilloid one activity, and increasing inhibitory mechanisms through modulation of cannabinoid and descending modulatory systems hold promise for osteoarthritis pain therapy.”

http://www.ncbi.nlm.nih.gov/pubmed/25730180

http://www.thctotalhealthcare.com/category/osteoarthritis/

 

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Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice.

“Leptin is an anorexigenic mediator that reduces food intake by acting on hypothalamic receptor, Ob-Rb. In contrast, endocannabinoids are orexigenic mediators that act via cannabinoid CB1 receptors in hypothalamus, limbic forebrain, and brainstem.

In the peripheral taste system, leptin administration selectively inhibits behavioral, taste nerve and taste cell responses to sweet compounds. Opposing the action of leptin, endocannabinoids enhance sweet taste responses.

Taken together, our results suggest that circulating leptin, but not local endocannabinoids, may be a dominant modulator for sweet taste in lean mice; however, endocannabinoids may become more effective modulators of sweet taste under conditions of deficient leptin signaling, possibly due to increased production of endocannabinoids in taste tissue.”

http://www.ncbi.nlm.nih.gov/pubmed/25728242

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Hebrew U. Researchers Find Cannabis Can Strengthen Bones

Arutz Sheva

“Researchers at Hebrew University have found that extracts from the cannabis plant can help strengthen human bones, preventing osteoporosis, according to an Israel21c report.”

http://www.israelnationalnews.com/News/News.aspx/96146#.VPH1lE33-ix

“Peripheral cannabinoid receptor, CB2, regulates bone mass… These results demonstrate that the endocannabinoid system is essential for the maintenance of normal bone mass by osteoblastic and osteoclastic CB2 signaling. Hence, CB2 offers a molecular target for the diagnosis and treatment of osteoporosis, the most prevalent degenerative disease in developed countries.” http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1334629/

http://www.thctotalhealthcare.com/category/osteoporosis-2/

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Peripheral cannabinoid receptor, CB2, regulates bone mass.

“Here we show that CB2-deficient mice have a markedly accelerated age-related trabecular bone loss and cortical expansion, although cortical thickness remains unaltered.

These changes are reminiscent of human osteoporosis and may result from differential regulation of trabecular and cortical bone remodeling…

These results demonstrate that the endocannabinoid system is essential for the maintenance of normal bone mass by osteoblastic and osteoclastic CB2 signaling.

Hence, CB2 offers a molecular target for the diagnosis and treatment of osteoporosis, the most prevalent degenerative disease in developed countries.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1334629/

http://www.thctotalhealthcare.com/category/osteoporosis-2/

 

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Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells.

X-ray generic

“Age-related osteoporosis is characterized by reduced bone formation and accumulation of fat in the bone marrow compartment.

Here, we report that the type 1 cannabinoid receptor (CB1) regulates this process…

The CB1 receptor is therefore unique in that it regulates peak bone mass through an effect on osteoclast activity, but protects against age-related bone loss by regulating adipocyte and osteoblast differentiation of bone marrow stromal cells.”

http://www.ncbi.nlm.nih.gov/pubmed/19656492

“Cannabis may prevent osteoporosis”  http://news.bbc.co.uk/2/hi/uk_news/scotland/edinburgh_and_east/8199007.stm

http://www.thctotalhealthcare.com/category/osteoporosis-2/

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Marijuana: A Time-Honored but Untested Treatment for Epilepsy.

Image result for marijuana

“The biology of the endocannabinoid system in the brain provides a possible basis for a beneficial pharmacological effect of marijuana on seizures.

However, evidence for efficacy of cannabis treatment of epilepsy is anecdotal because no acceptable randomized controlled trials have been done.

Proper dosage and means of administration remain unknown.

Cannabis is safer than other controlled substances, including tobacco or alcohol, and appears to be relatively safe compared with most pharmaceuticals used to treat epilepsy.”

 http://www.ncbi.nlm.nih.gov/pubmed/25715711

http://www.thctotalhealthcare.com/category/epilepsy-2/

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Simultaneous inhibition of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) shares discriminative stimulus effects with ∆9-THC in mice.

“Δ9 -tetrahydrocannabinol (∆9 -THC) is a cannabinoid CB1 /CB2 receptor agonist that produces therapeutic effects such as analgesia and anti-emetic effects…

Collectively, the current results show that pharmacological increases in endogenous AEA and 2-AG simultaneously through inhibition of FAAH and MAGL, respectively, mimics the discriminative stimulus effects of Δ9 -THC.”

http://jpet.aspetjournals.org/content/early/2015/02/24/jpet.115.222836.long

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Influence of nitric oxide synthase or cyclooxygenase inhibitors on cannabinoids activity in streptozotocin-induced neuropathy.

“The results of this study seemed to indicate that the interaction between cannabinoid, COX-2 and NOS(s) systems might exist…

Concomitant administration of small doses of CB1 and/or CB2 receptor agonists and COX-2 or NOS inhibitors can be effective in the alleviation of diabetic neuropathic pain.”

http://www.ncbi.nlm.nih.gov/pubmed/25712641

http://www.thctotalhealthcare.com/category/neuropathic-pain/

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