Marijuana in the management of amyotrophic lateral sclerosis

“Marijuana in the management of amyotrophic lateral sclerosis… Marijuana has been proposed as treatment for a widening spectrum of medical conditions. Marijuana is a substance with many properties that may be applicable to the management of amyotrophic lateral sclerosis (ALS). These include analgesia, muscle relaxation, bronchodilation, saliva reduction, appetite stimulation, and sleep induction. In addition, marijuana has now been shown to have strong antioxidative and neuroprotective effects, which may prolong neuronal cell survival. In areas where it is legal to do so, marijuana should be considered in the pharmacological management of ALS…”

http://www.ncbi.nlm.nih.gov/pubmed/11467101

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The endocannabinoid system in amyotrophic lateral sclerosis

“The endocannabinoid system in amyotrophic lateral sclerosis… Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative condition… there is significant evidence that several neurotoxic mechanisms including excitotoxicity, inflammation and oxidative stress, all contribute to disease pathogenesis… there is increasing evidence that cannabinoids and manipulation of the endocannabinoid system may have therapeutic value in ALS, in addition to other neurodegenerative conditions. Cannabinoids exert anti-glutamatergic and anti-inflammatory actions through activation of the CB(1) and CB(2) receptors… cannabinoid agents also exert anti-oxidant actions… the ability of cannabinoids to target multiple neurotoxic pathways in different cell populations increase their therapeutic potential in the treatment of ALS.”

http://www.ncbi.nlm.nih.gov/pubmed/18781981

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Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials

“Cannabis and amyotrophic lateral sclerosis… Significant advances have increased our understanding of the molecular mechanisms of amyotrophic lateral sclerosis (ALS)… It appears that a number of abnormal physiological processes occur simultaneously in this devastating disease. Ideally, a multidrug regimen… would be required to comprehensively address the known pathophysiology of ALS.REMARKABLY, CANNABIS APPEARS to have activity in all of those areas. Preclinical data indicate that cannabis has POWERFUL antioxidative, anti-inflammatory, and neuroprotective effects… Based on the currently available scientific data, it is reasonable to think that cannabis might significantly slow the progression of ALS, potentially extending LIFE expectancy and substantially reducing the overall burden of the disease.”

http://www.ncbi.nlm.nih.gov/pubmed/20439484

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