“Cannabinoid receptor agonists have gained attention as potential therapeutic targets of inflammatory and neuropathic pain. Here, we report the identification and optimization of a series of 7-oxo-[1,4]oxazino[2,3,4-ij]qu
“Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury… These results demonstrate that the improvement in motor and autonomic function resulting from treatment with a selective CB2 agonist is associated with a significant effect on inflammatory responses in the spinal cord following injury.”
“Cannabis-based medicines have a number of therapeutic indications, including anti-inflammatory and analgesic effects… cannabis-based drugs have therapeutic potential in inflammatory diseases, including rheumatoid arthritis (RA) and multiple sclerosis (MS)…aim of this study was to determine whether the key elements of the endocannabinoid signalling system.. are expressed in the synovia of patients with osteoarthritis (OA) or RA… Our data predict that the cannabinoid receptor system present in the synovium may be an important therapeutic target for the treatment of pain and inflammation associated with OA and RA.”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453762/?tool=pubmed
“We observe significant improvement of symptoms of FM in patients using cannabis… knowledge of the endocannabinoid system and the role of the stress system in the pathopysiology of FM suggest a new approach to the suffering of these patients… results together with previous evidence seem to confirm the beneficial effects of cannabinoids on FM symptoms.”
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080871/?tool=pubmed
TRUTH: “Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors… nonpsychoactive cannabinoids can potentiate glycine receptors (GlyRs), an important target for nociceptive regulation at the spinal level… We report that systemic and intrathecal administration of cannabidiol (CBD), a major nonpsychoactive component of marijuana, and its modified derivatives significantly suppress chronic inflammatory and neuropathic pain without causing apparent analgesic tolerance… These cannabinoids may represent a novel class of therapeutic agents for the treatment of chronic pain and other diseases involving GlyR dysfunction.”